Bone Marrow Transplant Program

Our Bone Marrow Transplant program is committed to developing leading-edge strategies for autologous and allogeneic bone marrow and peripheral blood stem cell transplantation for a wide variety of hematologic malignancies, solid tumors and other life-threatening hematologic disorders.
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Bone Marrow Transplant Survivorship Program


The Massachusetts General Hospital Cancer Center's Bone Marrow Transplant (BMT) Program is world-renowned for its expertise in hematopoietic cell transplantation to treat a wide variety of hematological conditions. Currently, we conduct over 200 transplant procedures annually. In addition to comprehensive and compassionate multi-disciplinary care for our patients, we also conduct leading-edge clinical and translational research to develop innovative strategies for improving the outcomes of patients undergoing BMT.

Our program is advancing clinical care and research in several areas and these include:

Reducing the toxicities of BMT:

  • Development of new strategies for reducing both acute and chronic transplant related toxicities
  • Analysis of patient-reported quality of life undergoing BMT and developing new interventions to improve the experience of our patients and their caretakers
  • BMT Survivorship program to better address the long-term health needs of patients after transplant

Novel treatment approaches against graft-vs-host disease (GVHD):

  • Participation in national consortiums and clinical trials studying acute and chronic GVHD
  • Development of new therapies to prevent acute and chronic GVHD
  • Development of new therapies to treat acute and chronic GVHD
  • Restoration of microbiome diversity after BMT through fecal microbiota transplantation (FMT)

Developing safer and more effective stem cell transplant protocols for patients who do not have a fully matched related or unrelated donor:

  • Novel strategies using umbilical cord blood
  • Innovative protocols involving haploidentical (partially matched relatives) donors

Reducing disease relapse after stem cell transplantation:

  • Study the use of maintenance therapies after both autologous and allogeneic transplantation to reduce disease relapse

Increasing tolerance for solid organ transplants by performing combined kidney and bone marrow transplants for patients who have both advanced kidney disease and an underlying blood disease.

Collaborate with other colleagues in the Mass General Cancer Center to deliver innovative cellular therapies including chimeric antigen T-cells (CAR-T) and customized T-cell products.

Meet the Team

Our BMT team's multidisciplinary approach to evaluation, management, and treatment provides each patient with individually tailored care.

  • Yi-Bin Chen, MD

    Director, BMT Program
    Cara J. Rogers Endowed Scholar
    Associate Professor of Medicine, Harvard Medical School

See the Complete List of BMT Team Members

Patient Education

Information about Bone Marrow Transplant Procedures

Bone marrow — the soft, spongy tissue inside the large bones in the body — can be affected by a variety of blood disorders, blood cancers and other diseases. Hematopoietic (blood) stem cells live in the bone marrow and give rise to all of the other components of the blood.

Bone marrow or stem cell transplants are performed for several reasons:

1. To rescue and restore blood components after the patient has received high doses of chemotherapy or radiation as treatment
2. To replace the patient’s blood system because their own is failing
3. To replace the patient’s blood system in order to grow a new immune system which can attack the patient’s cancer

The terms bone marrow transplant and stem cell transplant are used somewhat interchangeably.  For various reasons, one may receive bone marrow or blood stem cells.

Autologous vs. Allogenic Stem Cell or Bone Marrow Transplants

There are two basic types of bone marrow transplant procedures:

  • In an autologous bone marrow transplant, patients receive their own stem cells
  • In an allogeneic bone marrow transplant, patients receive donor stem cells

Following a bone marrow transplant, the donated stem cells start making new blood cells and other components from within the bone marrow.

Learn more about Bone Marrow Transplant

Clinical Trials

Clinical trials are research studies of new drugs, new combinations of drugs or already approved drugs being studied to treat patients in new/different ways. They may include new drug doses or new ways (schedules) to give the drugs. Clinical trials are run under strict guidelines. Their purpose is to help find out whether new cancer treatments are safe and effective or better than the standard (current) treatment. At Massachusetts General Hospital Cancer Center, there are several clinical trials open for the treatment of cancer that use the latest in cancer treatments.

Cancer is increasingly becoming a disease in which the genetic make-up of each individual cancer drives therapy. The Bone Marrow Treatment Program has access to clinical trials involving these targeted therapy approaches.

Contact Yi-Bin Chen, MD, Director, BMT Program, with questions about Bone Marrow Transplant Clinical Trials:

Find listings of our current clinical trials.



If you have any questions or would like to speak with one of our physicians, please call the Bone Marrow Transplant Program at (617) 724-1124.

Honors & Awards

BMT team the one hundred honorees

View BMT team members honored for their commitment to the fight against cancer.

2016 Thomas R. Spitzer Clinician of the Year

To honor his years of dedication and service, the Mass General Cancer Center announced in 2016 the Thomas R. Spitzer Clinician of the Year Award which will be given each year to a clinician in the division of Hematology/Oncology who exemplifies and embodies the clinical and academic values that Tom Spitzer has demonstrated for years at Mass General. The inaugural recipient in 2016 was Dr. Steven McAfee of the BMT Program.

2015 Jane Grier Memorial Prize

The Mass General Cancer Center awards the annual Jane Grier Memorial Prize each year to a faculty member who is recognized for their commitment to hematology / oncology education of fellows and young faculty. Yi-Bin Chen, MD was selected in 2015, having been nominated by fellows and young faculty for his mentorship to their careers.

Cara J. Rogers Endowed Scholar

In 2013 the Rogers Family Foundation established the Cara J. Rogers Endowed Scholar to Advance Research in Bone Marrow Transplantation. Learn how Yi-Bin Chen, MD is working to improve outcomes for patients who undergo transplants. Read More

Request an Appointment

Talk to an access nurse today 877-726-5130

Bone Marrow Transplant Survivorship Program

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