Bone Marrow Transplant Treatment Program

Our Bone Marrow Transplant program is committed to developing leading-edge strategies for autologous and allogeneic bone marrow and peripheral blood stem cell transplantation for a wide variety of hematologic malignancies, solid tumors and other life-threatening hematologic disorders.
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Talk to an access nurse today 877-726-5130

Bone Marrow Transplant Survivorship Program


The Massachusetts General Hospital Cancer Center's Bone Marrow Transplant (BMT) Program is world-renowned for its expertise in bone marrow transplantation to treat a wide variety of hematological conditions.  We also conduct leading-edge clinical and translational  research to develop innovative strategies for improving the outcomes of patients undergoing bone marrow transplant.

Our program is advancing clinical care and research in several areas and these include:

  • Reducing the side effects of BMT
    o Developing new strategies for reducing both acute and chronic transplant related toxicities
    o Studying the quality of life reported by patients undergoing BMT and developing new interventions to improve the experience of our patients and their caretakers
    Creating a BMT Survivorship program to better address the long-term health needs of patients after transplant
  • Novel treatment approaches against graft-vs.-host disease (GVHD)
    o Participation in national consortiums studying GVHD
    o Development of new therapies to treat acute and chronic GVHD
  • Developing safer and more effective stem cell transplant protocols for patients who do not have a fully matched related or unrelated donor
    o Novel strategies using umbilical cord blood
    o Innovative protocols involving haploidentical (half-matched relatives) donors
  • Reducing disease relapse after stem cell transplantation
  • Studying the use of maintenance therapies after both autologous and allogenic transplantation to reduce disease relapse
  • Increasing tolerance for solid organ transplants by
  • Performing combined kidney and bone marrow transplants for patients who have both advanced kidney disease and an underlying blood disease

Developing Better Therapies through Translational Research

The Bone Marrow Transplant Program benefits from a close association with the Transplant Biology Research Center. We are dedicated to understanding the basic immunologic mechanisms through which specific tolerance can be induced for solid organ transplants by performing combined bone marrow and organ transplants. We are also conducting investigations into the mechanism of the graft versus tumor effect of BMT and how it can be separated from graft versus host disease to improve overall outcomes for our patients.

Meet the Team

Our BMT team's multidisciplinary approach to evaluation, management, and treatment provides each patient with individually tailored care.

See the complete team list treating Bone Marrow Transplants

Patient Education

Information about Bone Marrow Transplant Procedures

Bone marrow — the soft, spongy tissue inside the large bones in the body — can be affected by a variety of blood disorders, blood cancers and other diseases. Hematopoietic (blood) stem cells live in the bone marrow and give rise to all of the other components of the blood.

Bone marrow or stem cell transplants are performed for several reasons:

1. To rescue and restore blood components after the patient has received high doses of chemotherapy or radiation as treatment
2. To replace the patient’s blood system because their own is failing
3. To replace the patient’s blood system in order to grow a new immune system which can attack the patient’s cancer

The terms bone marrow transplant and stem cell transplant are used somewhat interchangeably.  For various reasons, one may receive bone marrow or blood stem cells.

Autologous vs. Allogenic Stem Cell or Bone Marrow Transplants

There are two basic types of bone marrow transplant procedures:

  • In an autologous bone marrow transplant, patients receive their own stem cells
  • In an allogeneic bone marrow transplant, patients receive donor stem cells

Following a bone marrow transplant, the donated stem cells start making new blood cells and other components from within the bone marrow.

Learn more about Bone Marrow Transplant

Clinical Trials

Clinical trials are research studies of new drugs, new combinations of drugs or already approved drugs being studied to treat patients in new/different ways. They may include new drug doses or new ways (schedules) to give the drugs. Clinical trials are run under strict guidelines. Their purpose is to help find out whether new cancer treatments are safe and effective or better than the standard (current) treatment. At Massachusetts General Hospital Cancer Center, there are several clinical trials open for the treatment of cancer that use the latest in cancer treatments.

Cancer is increasingly becoming a disease in which the genetic make-up of each individual cancer drives therapy. The Bone Marrow Treatment Program has access to clinical trials involving these targeted therapy approaches.

Contact Yi-Bin Chen, MD, Director of Clinical Research, with questions about Bone Marrow Transplant Clinical Trials:

Find listings of our current clinical trials.



If you have any questions or would like to speak with one of our physicians, please call the Bone Marrow Transplant Program at (617) 724-1124.

Request an Appointment

Talk to an access nurse today 877-726-5130

Bone Marrow Transplant Survivorship Program

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