Wolfram Goessling's Research

Address:

Zon Laboratory
Stem Cell Program
Hematology/Oncology
Children's Hospital

Karp Family Research Building
1 Blackfan Circle
Boston, MA 02115
phone: 617-919-2080
fax: 617-730-0222



Current Projects:

Liver disease is a common cause for morbidity and mortality in the U.S., and understanding the critical pathways during liver development is essential for our knowledge of normal liver function and disease. The zebrafish is an excellent model to study early vertebrate development because of its translucency during development and the ability to produce large numbers of offspring. We are using the zebrafish system to study the effects of wnt signaling on liver and early endodermal development, liver regeneration, and hepatocarcinogenesis.

Recent Publications:

  • Goessling W, McKee PH, Mayer RJ: Merkel cell carcinoma. Journal of Clinical Oncology 20(2): 588-598, 2002.

  • Goessling W, Chung R. Amebic Liver Abscess. Curr Treat Options Gastroenterol. 5(6): 443-449, 2002.

  • Goessling W, Skarin AT. Metastatic cancer of unknown primary. Hospital Physician 2004.

  • Goessling W, Friedman LS Increased liver chemistry in an asymptomatic patient. Clinical Gastroenterology and Hepatology 3(9): 852-858, 2005.

  • Goessling W, Mayer RJ: Systemic treatment of patients with colorectal cancer and inflammatory bowel disease. Gastroenterol Clin North Am. 35(3):713-27, 2006.