Daniel C. Chung, MD

Assistant Professor in Medicine
Harvard Medical School
Director, GI Cancer Genetics Clinic
Address: Massachusetts General Hospital
Blake 4
55 Fruit St.
Boston, MA 02114
Patient Appointments: (617) 726-3544
Fax: (617) 724-5997
E-Mail: dchung@partners.org
Education:  
MD Degree: Harvard Medical School, 1988
Residency: Massachusetts General Hospital, 1991
Fellowship: Massachusetts General Hospital, 1995
Board Certifications: Internal Medicine, 1991, 2001
Gastroenterology, 1993, 2003
Clinical Interests: Familial GI Cancer syndromes
(FAP, HNPCC)
Colorectal Cancer
GI Endocrine Tumors
General Gastroenterology

Research Interests:

Ongoing basic and clinical research projects focus on identifying some of the key molecular genetic alterations underlying gastrointestinal malignancies, particularly colon cancer.

Recent Publications:

  1. Choi MY, Lauwers GY, Hur C, Willett CG, Chung DC. Microsatellite instability is frequently observed in rectal cancer and influenced by neoadjuvant chemoradiation. International Journal of Radiation Oncology Biology Physics, 2007, 68:1584.

  2. Mizukami Y, Kohgo Y, Chung DC. HIF-1 independent regulation of angiogenesis. Clinical Cancer Research. 2007, 13:5670-74.

  3. Mizukami Y, Fujiki K, Duerr EM, Gala M, Jo WS, Zhang X, Chung DC. Hypoxic regulation of vascular endothelial growth factor through the induction of PI3K/Rho/ROCK and c-Myc. Journal of Biological Chemistry, 2006, 281:13957-63.

  4. Bertagnolli MM, Eagle CJ, Zauber AG, Redston M, Solomon SD, Kim KM, Tang J, Rosenstein RB, Wittes J, Corle D, Hess TM, Woloj GM, Boisserie F, Anderson WF, Viner JL, Bagheri D, Burn J, Chung DC, Dewar T, Foley TR, Hoffman N, MacRae F, Pruitt RE, Saltzman JR, Salzberg B, Sylwestrowicz T, Gordon GB, Hawk ET, for the APC Study Investigators. Celecoxib for the prevention of sporadic colorectal adenomas. New England Journal of Medicine, 2006, 355:873-84.

  5. Mizukami Y, Jo WS, Duerr EM, Gala M, Li J, Zhang XB, Zimmer MA, Iliopoulos O, Zukerberg LR, Lynch MP, Rueda BR, Chung DC. Induction of interleukin-8 preserves the angiogenic response in HIF-1 deficient colon cancer cells. Nature Medicine, 2005, 11:992-97.

  6. Jo WS, Chung DC. Genetics of hereditary colon cancer. Seminars in Oncology, 2005, 32:11-23.

  7. Li J, Mizukami Y, Zhang X, Jo WS, Chung DC. Oncogenic K-ras stimulates Wnt signaling in colon cancer through inhibition of GSK-3beta. Gastroenterology, 2005, 128:1907-18.

  8. Velayos FS, Allen BA, Conrad PG, Gum Jr. J, Kakar S, Chung DC, Truta B, Sleisenger MH, Kim YS, Terdiman JP. Low rate of microsatellite instability in young patients with adenomas: Reassessing the Bethesda Guidelines. American Journal of Gastroenterology, 2005, 100:1143-49.

  9. Costa-Guda J, Rosen ED, Jensen RT, Chung DC, Arnold A. Mutational analysis of PPARG as a candidate tumor suppressor gene in enteropancreatic endocrine tumors. Clinical Endocrinology, 2005, 62:603-6.

  10. Zhang X, Gaspard JP, Mizukami Y, Li J, Graeme-Cook F, Chung DC. Overexpression of cyclin D1 in pancreatic beta-cells in vivo results in islet hyperplasia without hypoglycemia. Diabetes, 2005, 54:712-19.

  11. Chung DC. Cyclin D1 in human neuroendocrine tumorigenesis, in Gastroenteropancreatic neuroendocrine tumor disease: molecular and cell biological aspects. Annals of NY Academy of Sciences 2004, 1014:209-217.

  12. Willett CG, Boucher Y, Di Tomaso E, Duda DG, Munn LL, Tong RT, Chung DC, Sahani DV, Kalva SP, Kozin SV, Mino M, Cohen KS, Scadden DT, Hartford AC, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Chen HX, Shellito PC, Lauwers GY, Jain RK. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nature Medicine, 2004, 10:145-47.

  13. Mizukami Y, Li J, Zhang X, Zimmer M, Iliopoulos O, Chung DC. HIF-1 independent regulation of VEGF by hypoxia in colon cancer. Cancer Research 2004, 64:1765-72.

  14. Chung DC, Rustgi AK. The Hereditary Nonpolyposis Colorectal Cancer syndrome: genetics and clinical implications. Annals of Internal Medicine, 2003, 138:560-570.

  15. Yoo LI, Chung DC, Yuan J. LKB1: a master tumor suppressor of the small intestine and beyond. Nature Reviews Cancer, 2002, 2:529-535.

  16. Shattuck TM, Costa J, Bernstein M, Jensen RT, Chung DC, Arnold A. Mutational analysis of Smad3, a candidate tumor suppressor implicated in TGFb and menin pathways, in parathyroid adenomas and enteropancreatic endocrine tumors, Journal of Clinical Endocrinology and Metabolism, 2002, 87:3911-14.

  17. Wu C-L, Kirley SD, Xiao H, Chuang Y, Chung DC, Zukerberg LR. Cables enhances Cdk2 tyrosine15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers. Cancer Research, 2001, 61:7325-7332.

  18. Zhang XB, Gaspard J, Chung DC. Regulation of VEGF by the Wnt and K-ras pathways in colonic neoplasia. Cancer Research, 2001, 61:6050-54.

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