Daniel K. Podolsky, MD

Chief, Gastrointestinal Unit
Massachusetts General Hospital
Mallinckrodt Professor of Medicine
Faculty Dean for Academic Programs at Partners
Harvard Medical School
Chief Academic Officer, Partners HealthCare System

Research Interests:

My research interest encompasses laboratory investigation of basic mechanisms contributing to gastrointestinal tract injury and the pathogenesis of inflammatory bowel diseases. The latter includes the study of key genes involved in the regulation of the intestinal surface epithelium, its interaction with bacteria, as well as the mechanism of innate immunity. I am also involved in the development and evaluation of new therapies for patients with inflammatory bowel diseases.

Recent Publications:

1. Barnich N, Aguirre JE, Reinecker HC, Xavier R, Podolsky DK. Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition. J Cell Biol. 2005 Jul 4;170(1):21-6.
   
   
2. Barnich N, Hisamatsu T, Aguirre JE, Xavier R, Reinecker HC, Podolsky DK. GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells. J Biol Chem. 2005 May 13;280(19):19021-6
   
   
3. Cario E, Gerken G, Podolsky DK. Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C. Gastroenterology. 2004 Jul;127(1):224-38.
   
   
4. Otte JM, Cario E, Podolsky DK. Mechanisms of cross hyporesponsiveness to Toll-like receptor bacterial ligands in intestinal epithelial cells. Gastroenterology. 2004 Apr;126(4):1054-70.
   
   
5. Beck PL, Wong JF, Li Y, Swaminathan S, Xavier RJ, Devaney KL, Podolsky DK. Chemotherapy- and radiotherapy-induced intestinal damage is regulated by intestinal trefoil factor. Gastroenterology. 2004 Mar;126(3):796-808.
   
   
6. Otte JM, Rosenberg IM, Podolsky DK. Intestinal Myofibroblasts in Innate Immune Responses of the Intestine. Gastroenterol 2003; 124:1866-1878.
   
   
7. Hisamatsu T, Suzuki M, Reinecker H-C, Nadeau WJ, McCormick BA, Podolsky DK. CARD15/NOD2 Functions as an Anti-bacterial Factor in Human Intestinal Epithelial Cells. Gastroenterol 2003;124(4):993-1000.
   
   
8. Beck PL, Rosenberg IM, Xavier RJ, Koh T, Wong JF, Podolsky DK. Transforming Growth Factor - Beta Mediates Intestinal Healing and Susceptibility to injury in Vitro and in Vivo Through Epithelial Cells. Amer J Pathol 2003;162(2):597-608.
   
   
9. Cario E, Brown D, McKee M, Lynch-Devaney K, Gerken G, Podolsky DK. Commensal-Associated Molecular Patterns Induce Selective Toll-Like Receptor-Trafficking from Apical Membrane to Cytoplasmic Compartments in Polarized Intestinal Epithelium. Am J Pathol 2002;160(1):165-173.
   
   
10. Podolsky DK. "Inflammatory Bowel Disease." New England Journal of Medicine 2002;347(6):417-429.
    
    
11. Taupin D, Kinoshita K, Podolsky DK. Intestinal trefoil factor confers colonic epithelial resistance to apoptosis. PNAS 2000;97(2):799-804.
    
    
12. Kinoshita K, Taupin DR, Itoh H, Podolsky DK. Distinct pathways of cell migration and anti-apoptotic response to epithelial injury: structure-function analysis of human intestinal trefoil factor. Mol Cell Biol 2000;20:4680-4690.
    
    
13. Cario E, Podolsky DK. Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infection & Immunity, Dec. 2000;7010-7017.