Massachusetts General Hospital (MGH) investigators have determined that one of the recently identified genes contributing to the risk of late-onset Alzheimer's disease regulates the clearance of the toxic amyloid beta (A-beta) protein that accumulates in the brains of patients with the disease. In their report receiving advance online publication in Neuron, the researchers describe a protective variant of the CD33 gene that promotes clearance of A-beta from the brain. They also show that reducing expression of CD33 in immune cells called microglia enhances their ability to clear away A-beta protein, raising the possibility that blocking CD33 activity could help the brain’s immune system remove A-beta. Read more.
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5/15/13: Study finds disagreement on the role of primary care nurse practitioners A New England Journal of Medicine study finds that, while primary care physicians and nurse practitioners agree that nurse practitioners "should be able to practice to the full extent of their education and training," they significantly disagree about some proposed changes to the scope of nurse practitioners' responsibilities.
5/14/13: Treatment with two osteoporosis drugs better at increasing bone density than single-drug therapy A combination of two FDA-approved osteoporosis drugs with different mechanisms of action was found to increase bone density better than treatment with either drug alone in a small clinical trial.
5/13/13: Massachusetts General Hospital Receives Highest Nursing Credential With Prestigious Magnet® Recognition … Again The Massachusetts General Hospital has again attained Magnet® recognition as part of the American Nurses Credentialing Center’s Magnet Recognition Program®. This voluntary credentialing program recognizes excellence in nursing and is the highest honor an organization can receive for professional nursing practice.
5/08/13: Mass. General, Duke study identifies two genes that combine to cause rare syndrome Researchers from MGH and Duke University have identified genetic mutations that appear to underlie a rare but devastating syndrome combining reproductive failure with cerebellar ataxia – a lack of muscle coordination – and dementia.
5/05/2013: Portable device provides rapid, accurate diagnosis of tuberculosis, other bacterial infections A handheld diagnostic device that MGH investigators first developed to diagnose cancer has been adapted to rapidly diagnose tuberculosis and other important infectious bacteria.
5/02/13: Gene variant appears to predict weight loss after gastric bypass MGH researchers have identified a gene variant that helps predict how much weight an individual will lose after gastric bypass surgery, a finding with the potential both to guide treatment planning and to facilitate the development of new therapeutic approaches to treating obesity and related conditions like diabetes.
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05/15/2013: Doctors Reluctant to Expand Nurse Practitioners' Role: Survey
coverage of study led by MGH investigator Karen Donelan
05/15/2013: Docs and Nurse Practitioners Have Different Role Perceptions
HealthDay Physicians Briefing
05/15/2013: Doctors dismiss nurses skills, survey finds
05/15/2013: MDs Vs NPs: Can There Be a Happy Ending?
05/15/2013: Docs, Nurses Disagree Over Expanded Nurse Roles
Kaiser Health News
05/15/2013: Alternative Treatments for Chronic Pain
quotes MGH physician Anne Louise Oaklander