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Mass. General researchers and the colleagues add to understanding of the role of the protein COX2 in pain associated with inflammation.

Nerve cells in the brain and spinal cord sense pain caused by physical insult


A team of researchers at Massachusetts General Hospital and the University of Pennsylvania has shown that the protein COX2, which functions to produce soluble molecules known as prostaglandins. Although it is known that COX2 in mouse central nervous system cells is crucial for some forms of pain associated with inflammation but not others.

Link to Journal of Clinical Investigation release.

Media Contacts: Sue McGreevey,


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