Thursday, November 24, 2011

Rebuilding the Brain’s Circuitry

Carefully selected young, healthy neurons can functionally integrate into diseased brain circuitry

Neuron transplants have repaired brain circuitry and substantially normalized function in mice with a brain disorder, an advance indicating that key areas of the mammalian brain are more reparable than was widely believed.

Collaborators from Harvard University, Massachusetts General Hospital, Beth Israel Deaconess Medical Center and Harvard Medical School transplanted normally functioning embryonic neurons at a carefully selected stage of their development into the hypothalamus of mice unable to respond to leptin, a hormone that regulates metabolism and controls body weight.

Link to full Harvard Medical School release.

MGH-HMS Center for Nervous System Repair.

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