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James A. (James) MacLean, MD

Associate Clinical Physician, MGH

Clinical Assistant Professor, Harvard Medical School

Chief Allergy, North Shore Medical Center

  • Phone: 617-726-3850
Allergy and Immunology
Department of Medicine
Clinical Interests
Allergic rhinitis
Latex allergy
Drug hypersensitivity
Food allergy
Boston: Massachusetts General Hospital
Medical Education
MD, McGill University
Residency, Royal Victoria Hospital
Board Certifications
Internal Medicine, American Board of Internal Medicine
Allergy & Immunology, American Board of Internal Medicine
Foreign Languages
Patient Age Group
Accepting New Patients
Accepting New Patients


Dr. MacLean is a board certified allergist / immunologist. He sees patients with any of the following cnoditions

  • Allergic Rhinitis (allergies including hay fever)
  • Asthma and related disorders
  • Chronic urticaria (hives) and angioedema
  • Drug Allergy (adverse reactions to medication)
  • Food Allergy
  • Sinusitis
  • Stinging insect allergy
  • Nasal Polyps
  • Non-HIV immune deficiency disorders


1. Silverman ES, De Sanctis GT, Boyce J, Maclean JA, Jiao A, Green FH, Grasemann H, Faunce D, Fitzmaurice G, Shi GP, Stein-Streilein J, Milbrandt J, Collins T, Drazen JM. The transcription factor early growth-response factor 1 modulates tumor necrosis factor-alpha, immunoglobulin E, and airway responsiveness in mice. Am J Respir Crit Care Med 2001;1;163(3):778-85.

2. Mathew A, MacLean JA, DeHaan E, Tager AM, Green FHY, Luster AD. Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation. J. Exp. Med. 2001;193:1087-96

3. MacLean JA, Eidelman FJ. The Genetics of Atopy and Atopic Eczema. Arch Dermatol 2001;137(11):1474-76.

4. Medoff BD, Sauty A, Tager AM, Maclean JA, Smith RN, Mathew A, Dufour JH, Luster AD. IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma. J Immunol 2002;15;168(10):5278-86.

5. MacLean JA, Hannaway PJ. Angioedema and AT1 receptor blockers: proceed with caution. Arch Intern Med. 2003;23;163(12). 

6. Ober AI, MacLean JA, Hannaway PJ.Life-threatening anaphylaxis to venom immunotherapy in a patient taking an angiotensin-converting enzyme inhibitor. J Allergy Clin Immunol. 2003;112(5):1008-9.
7. MacLean, JA. Wheezing and asthma: When to refer for an allergy evaluation. J. Respir. Dis Pediatrician. 2003;5(4):153-58.

In General: James M. Perrin, MD

In General awards and honors

Allergy Associates
55 Fruit Street
Cox Building
Boston, MA 02114-2696

Phone: 617-726-3850
Fax: 617-724-0239