Clinical Immunology Laboratory

The Clinical Immunology Laboratory provides both diagnostic and educational services to the Mass General community.

About This Procedure

The Clinical Immunology Laboratory offers a full range of clinical diagnostic services, including agarose gel electrophoresis, immunoelectrophoresis and immunofixation to detect monoclonal proteins in serum, urine and cerebrospinal fluid.  Other tests include indirect immunofluorescence, assay for detection of antinuclear antibodies, anti-native DNA antibodies, identification and characterization of cryoglobulins, detection of precipitin antibodies for hypersensitivity pneumonitis.  Utilizing ELISA assays the laboratory performs assays for SS-A, SS-B, Sm, RNP, anti-Scl-70 and Jo-1, anti-CCP and H.Pylori.  Utilizing rate nephelometry quantitation of serum and urine free light chains are performed and data coupled to interpretations of serum and urine electrophoresis and immunofixation analyses.  Evaluation of complement proteins, complement activation, determination of serum viscosity and analyses of joint fluid crystals are also performed. 

The application and clinical value of these tests are highlighted in the laboratory teaching sessions to residents and fellows in various fields of medicine by the Director during daily reporting and resulting sessions.


Director of the Clinical Immunology Laboratory - Mandakolathur Murali, MD

Location - Bulfinch 422; Hours of operation - Monday-Friday, 8:30am-5:00pm


Specimen Delivery:

All specimens should be delivered to the Chemistry Laboratory (Gray 5) for initial processing.

Criteria for Refusal of Specimens:

The laboratory reserves the right to refuse specimens under the following conditions:

  1. Specimens collected in the wrong container.
  2. Specimens improperly labeled OR unlabeled.
  3. Specimens not placed on ice, if required.
  4. Specimens for cryoprotein determination MUST be received in warm water, at approximately 37° C.


Results are available on the Clinical Application Suite (CAS) and Longitudinal Medical Record (LMR) as soon as they are verified and signed off by the Director. Written results are sent to the Requesting Area and the Medical Records Room.


For further information, contact: Dr. Mandakolathur Murali, Director, Clinical Immunology Laboratory

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