Browse our interactive material, read recent ALS publications and news articles, or find information on our upcoming events.
The Northeast ALS Consortium (NEALS) website is devoted to supporting clinical research of Amyotrophic Lateral Sclerosis (ALS) and other motor neuron disease (MND).
01/30/2014: Calling all Veterans
Military veterans who are diagnosed with ALS are eligible for service-connected benefits.
01/30/2014: ALS Clinical Trials Liaison Available to Help Connect PALS With Clinical Research Information
NEALS and ALSA partner to offer clinical trial liaison service to help people with ALS navigate the world of clinical research.
Formal statement on the forthcoming US Brainstorm trial
09/23/2013: The Lancet: Neurology
Dexpramipexole vs placebo for patients with ALS (EMPOWER): a randomised, double-blind, phase 3 trial
In a phase III trial, dexpramipexole was generally well tolerated but did not differ from placebo on any pre-specified efficacy endpoint measurement. The trial can inform the design of future clinical research strategies in amyotrophic lateral sclerosis.
05/16/2012: Amyotrophic Lateral Sclerosis
Safety, tolerability and pharmacodynamics of a skeletal muscle activator in amyotrophic lateral scle
Published Phase II results demonstrated that single oral doses of 250 mg and 500 mg of CK-2017357 appeared safe and well-tolerated in patients with ALS.
03/13/2012: Stem Cells
Lumbar Intraspinal Injection of Neural Stem Cells in Patients with ALS: Results of a Phase I Trial i
The results of an ongoing Phase I trial of intraspinal injections of fetal-derived neural stems cells in patients with ALS.
11/20/2011: Nature Medicine
The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis
Phase II, two-part trial examining safety and tolerability of dexpramipexole in patients with ALS.
05/23/2010: Therapy Times
Tuesdays With an SLP
Paige Nalipinski, senior speech language pathologist and project coordinator at MGH, writes about ALS care guidelines and her experience working with patients at the MGH ALS Multidisciplinary Clinic.
05/01/2010: Lancet Neurology
Safety and efficacy of lithium in combination with riluzole for treatment of amyotrophic lateral scl
Double-blind, placebo-controlled trial with a time-to-event design assessing the safety and efficacy of lithium in combination with riluzole in patients with ALS.
07/01/2008: Muscle & Nerve
Arimoclomol at dosages up to 300 mg/day is well tolerated and safe in amyotrophic lateral sclerosis.
Safety, tolerability, and pharmacokinetics of arimoclomol in ALS were assessed.
07/01/2006: Annals of Neurology
Trial of celecoxib in amyotrophic lateral sclerosis
A double-blind, placebo-controlled, clinical trial to determine if celecoxib is safe and effective in ALS.
Tolerance of high-dose (3,000 mg/day) coenzyme Q10 in ALS
An open-label dose-escalation trial was performed to assess the safety and tolerability of high doses of coenzyme Q10 (CoQ10) in ALS.
A clinical trial of creatine in ALS
A randomized double-blind, placebo controlled trial on 104 patients with ALS from 14 sites to evaluate the efficacy of creatine supplementation in ALS.
A randomized, placebo-controlled trial of topiramate in amyotrophic lateral sclerosis
A double-blind, placebo-controlled, multicenter randomized clinical trial to determine if long-term topiramate therapy is safe and slows disease progression in patients with ALS.