Clinical Trials

The Cancer Center offers patients access to a wide variety of clinical trials of promising new therapies. Use the search tool below to find open protocols for your type of cancer. To learn more about eligibility and participation call 877-789-6100.

Search by conditions: 

Click a protocol # to view extended details on a particular clinical trial.

Protocol #DescriptionPhase
13-517 A Randomized, Double-blind, Placebo-controlled Phase 3 Study of the Bruton's Tyrosine Kinase (BTK) Inhibitor, PCI-32765 (Ibrutinib), in Combination With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Subjects With Newly Diagnosed Non-Germinal Center B-Cell Subtype of Diffuse Large B-Cell Lymphoma  (View details on clinicaltrial.gov)Phase III
14-191A Phase 1 Study of CPI-0610, a Small Molecule Inhibitor of BET Proteins, in Patients with Acute Leukemia, Myelodysplastic Syndrome, or Myelodysplastic/Myeloproliferative Neoplasms  (View details on clinicaltrial.gov)Phase I
12-461A Phase 1, Open-Label, Dose-Escalation Study of SGN-CD19A in Patients With B-Lineage Acute Lymphoblastic Leukemia and Highly Aggressive Lymphomas  (View details on clinicaltrial.gov)Phase I
11-380A Phase 2 Study of Brentuximab Vedotin in Patients With CD30-positive Non-Hodgkin Lymphoma  (View details on clinicaltrial.gov)Phase II
12-321A Phase 2, Controlled Trial, of a Single ProHema-CB Unit (Ex Vivo CXCR4-Upregulated CD34+ Hematopoietic Progenitor Cells, Cord Blood) as Part of a Double Umbilical Cord Blood Transplant Following Myeloablative Conditioning for Patients Age 15-55 Years with Hematologic Malignancies  (View details on clinicaltrial.gov)Phase II
11-447A Phase 3 Open-Label Randomized Study to Compare the Efficacy and Safety of Rituximab Plus Lenalidomide (CC-5013) Versus Rituximab Plus Chemotherapy Followed by Rituximab in Subjects With Previously Untreated Follicular Lymphoma (RELEVANCE)  (View details on clinicaltrial.gov)Phase III
13-539A Phase 3 Study of IPI-145 Versus Ofatumumab in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma  (View details on clinicaltrial.gov)Phase III
06-068A Phase I Safety, Pharmacokinetic and Pharmacodynamic Study of PF-02341066. A CMET/HGFR Selective Tyrosine Kinase Inhibitor, Administered Orally To Patients With Advanced Cancer  (View details on clinicaltrial.gov)Phase I
13-348A Phase I Study of CPI-0610, a Small Molecule Inhibitor of BET Proteins, in Patients with Progressive Lymphoma  (View details on clinicaltrial.gov)Phase I
13-165A Pilot Study of Oncaspar + Dexamethasone in Patients with Relapsed or Refractory T-Cell Lymphoma  (View details on clinicaltrial.gov)N/A
13-076A Randomized, Open-label, Phase 3 Trial of A+AVD Versus ABVD as Frontline Therapy in Patients With Advanced Classical Hodgkin Lymphoma  (View details on clinicaltrial.gov)Phase III
13-592A041202: A Randomized Phase III Study of Bendamustine Plus Rituximab Versus Ibrutinib Plus Rituximab Versus Ibrutinib Alone in Untreated Older Patients (≥ 65 Years of Age) with Chronic Lymphocytic Leukemia (CLL)  (View details on clinicaltrial.gov)Phase III
13-174An Open-label Phase II Study of BKM120 in Patients With Relapsed and Refractory Diffuse Large B-cell Lymphoma, Mantle Cell Lymphoma and Follicular Lymphoma  (View details on clinicaltrial.gov)Phase II
12-188BMT CTN 1101: A Multi-Center, Phase III, Randomized Trial of Reduced Intensity (RIC) Conditioning and Transplantation of Double Unrelated Umbilical Cord Blood (dUCB) versus HLA-Haploidentical Related Bone Marrow (haplo-BM) for Patients with Hematologic Malignancies  (View details on clinicaltrial.gov)Phase III
09-346Bortezomib plus Rituximab for Initial Systemic Therapy of EBV+ Post-Transplant Lymphoproliferative Disease (PTLD)  (View details on clinicaltrial.gov)Phase II
10-327CALGB 50801: Phase II Trial of Response-Adapted Therapy Based on Positron Emission Tomography (PET) for Bulky Stage I and Stage II Classical Hodgkin Lymphoma (HL)  (View details on clinicaltrial.gov)Phase II
10-116Phase II Study of Dose-Adjusted EPOCH-Rituxan in Adults with Untreated Burkitt Lymphoma and c-MYC Positive Diffuse Large B-Cell Lymphoma  (View details on clinicaltrial.gov)Phase II
17 clinical trials listed.

Through our founding membership in the Dana-Farber/Harvard Cancer Center, an NCI-designated Comprehensive Cancer Center, these clinical trials are conducted at the Massachusetts General Hospital Cancer Center and may be available at other partner institutions.