The Endocrine Tumor Genetics Clinic is a collaboration between the Center for Cancer Risk Assessment (CCRA) and Mass General’s Thyroid Associates Practice. At this clinic, patients will meet with a genetic counselor and an endocrinologist to review family history and discuss options for genetic testing. When a person has a personal or family history of tumors in the pancreas, thyroid, parathyroid, pituitary or adrenal glands, a referral for genetic counseling may be appropriate.

The two most common syndromes discussed at an Endocrine Tumor Genetics Clinic appointment are MEN1 and MEN2:

  • Multiple Endocrine Neoplasia, type 1 (MEN1): Individuals with MEN1 can develop tumors in the parathyroid glands, the pituitary gland, or endocrine tumors of the gastrointestinal tract, such as pancreatic neuroendocrine tumors. The gene responsible for this syndrome is also called MEN1. More information.
  • Multiple Endocrine Neoplasia, type 2 (MEN2): Individuals with MEN2 have a mutation in the RET gene. Patients with this syndrome develop specific cancers of the thyroid called medullary thyroid carcinoma. Some families are also at risk for tumors in the adrenal gland and the parathyroid glands. More information.

The Endocrine Tumor Genetics Clinic may discuss additional syndromes if suggested by the patient's clinical and/or family history. These include: Cowden syndrome; jaw tumor-hyperparathyroidism syndrome; hereditary pheochromocytoma/paraganglioma syndrome; familial hyperparathyroidism; von Hippel-Lindau syndrome (see the FRCC/VHL Clinic).

The Endocrine Tumor Genetics Clinic is held once per month, usually on the second Monday. Patients are seen at Wang Ambulatory Care Center, Suite 730S, 55 Fruit Street, Boston. The patient coordinator can be reached at 617-724-1971.

Clinic Physicians:

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