The Gastrointestinal Cancer Genetics Program is under the direction of Daniel C. Chung, MD, a gastroenterologist and researcher who also serves as clinical chief of the Massachusetts General Hospital Gastrointestinal Unit. Our staff includes specialists in both gastroenterology and genetics.

At this clinic, patients typically meet with a genetic counselor and Dr. Chung to review family and medical history and discuss options for genetic testing. We also provide recommendations for medical management.

Should You Consider Genetic Counseling?

A visit to our clinic may be right for you if you have a personal or family history of one or more of the following:

  • Early-onset colorectal, uterine, stomach or other gastrointestinal cancers
  • Two or more primary colon or gastrointestinal cancers
  • Early-onset or multiple gastrointestinal polyps
  • Multiple family members with pancreatic cancer

Hereditary Gastrointestinal Cancer Diseases

The syndromes most commonly discussed with patients in our clinic include:

  • Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC) syndrome: People with Lynch syndrome are at an increased risk of colon, uterine, stomach, ovarian, small bowel and other types of cancers. The genes responsible for this syndrome are MLH1, MSH2, MSH6, PMS2 and EPCAM.
  • Familial adenomatous polyposis (FAP) syndrome: People with FAP have a greater risk of developing multiple colon and other gastrointestinal polyps as well as certain types of colon and other gastrointestinal cancers. The gene responsible for this syndrome is APC.
  • MYH-associated polyposis (MAP) syndrome: MAP syndrome results in an increased risk of multiple colon and other gastrointestinal polyps as well as colorectal cancer. The gene responsible for this syndrome is MYH.
  • Hereditary diffuse gastric cancer (HDGC) syndrome: People with HDGC have an increased risk of developing diffuse stomach cancer and lobular breast cancer. The gene responsible for this syndrome is CDH1.
  • Familial pancreatic cancer: Some families have an increased risk of developing pancreatic cancer. Depending on the other cancers in the family, genetic testing may be appropriate to help assess the risk to family members.

Make an Appointment

If you are interested in a consultation with the GI Cancer Risk Assessment team, you can make an appointment at one of four locations:

Clinic Physicians

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