Advances at Mass General Cancer Center

Advances at Mass General Cancer Center is our electronic publication that highlights our investigators’ recent publications in high-profile journals.

Current Article

A New Therapeutic Target for Pancreatic Cancer

Can better understanding an epigenetic pathway lead to clues in one of the most lethal cancers? Download this article

Contributor

  • Raul Mostoslavsky, MD, PhD

    Principal Investigator, Mostoslavsky Laboratory, and Kristine and Bob Higgins Mass General Hospital Research Scholar, Mass General Hospital Cancer Center; Associate Professor of Medicine, Harvard Medical School

 

Pancreatic ductal adenocarcinoma (PDAC) accounts for 90% of all pancreatic cancers, and is one of the most lethal cancers in humans. PDAC is characterized by mutant KRAS, a gene involved in regulating cell division, but little is known about the molecular processes governing initiation, progression and metastasis in PDAC. As a consequence, no good new therapeutic targets have been identified for the cancer in three decades. Despite active research in this field, standard chemotherapy remains the primary treatment available for PDAC, and survival rates are under 5% after a year.

But understanding the mechanics at play in those tumors may lead to better treatments. Raul Mostoslavsky, MD, PhD, the Kristine and Bob Higgins Massachusetts General Hospital Research Scholar at Massachusetts General Hospital Cancer Center and the Laurel Schwartz Associate Professor of Oncology at Harvard Medical School, has identified an epigenetic pathway that is responsible for cancer growth in 30 to 40% of PDAC patients. Continue Reading

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This podcast is a companion to Mass General Cancer Center’s electronic publication, and both are centered around our investigators' recent publications in high-profile journals. Each expert will give you insight into who they are and what inspires them to do what they do every day. A deeper dive into their research will better your understanding of where our experts’ ideas come from, where they will go from here, and what the future has in store in their particular field of research.

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