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Advances at Mass General Cancer Center is our electronic publication that highlights our investigators’ recent publications in high-profile journals.
Can palliative care help patients with hematologic malignancies? Download this article
Program Director, Bone Marrow Transplant Survivorship, Mass General Cancer Center; Assistant Professor of Medicine, Harvard Medical School
Palliative care, which aims to alleviate symptoms and improve mood for patients with life-threatening illnesses, is increasingly common for individuals with solid tumors in advanced stages. But such care is rarely prescribed for patients with hematologic malignancies, even though standard hematopoietic cell transplantation (HCT) treatment for such cancers requires some of the highest dose chemotherapy—a course that can result in high symptom burdens and long, taxing hospital stays.(1)
This discrepancy exists in part because HCT treatment has curative intent, whereas palliative care has not been traditionally used in populations of patients receiving curative therapy. Although a number of clinical trials have shown that early integration of palliative care into treatment can significantly improve quality of life in patients with solid tumors, no trials have included HCT patients. Continue Reading
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This podcast is a companion to Mass General Cancer Center’s electronic publication, and both are centered around our investigators' recent publications in high-profile journals. Each expert will give you insight into who they are and what inspires them to do what they do every day. A deeper dive into their research will better your understanding of where our experts’ ideas come from, where they will go from here, and what the future has in store in their particular field of research.
How do tumors evolve to evade the immune response? Download this article
Director, Cancer Immunotherapy at Mass General Cancer Center; Associate Professor of Medicine, Harvard Medical School & Broad Institute
Director, Bioinformatics, Mass General Cancer Center and Department of Pathology; Paul C. Zamecnik Chair in Oncology, Mass General Cancer Center; Director, Cancer Genome Computational Analysis, Broad Institute Member, Broad Institute Associate Professor of Pathology, Harvard Medical School
While some patients with cancer mount a strong immune response against their tumors, most have no significant immune response against these invaders. Little is known, however, about what genetic and environmental factors shape an individual tumor’s response to the immune system, or about how the tumor and the immune system interact at a cellular and molecular level. Continue Reading
Companion Podcast Episodes:
Can better understanding an epigenetic pathway lead to clues in one of the most lethal cancers? Download this article
Principal Investigator, Mostoslavsky Laboratory, and Kristine and Bob Higgins Mass General Hospital Research Scholar, Mass General Hospital Cancer Center; Associate Professor of Medicine, Harvard Medical School
Pancreatic ductal adenocarcinoma (PDAC) accounts for 90% of all pancreatic cancers, and is one of the most lethal cancers in humans. PDAC is characterized by mutant KRAS, a gene involved in regulating cell division, but little is known about the molecular processes governing initiation, progression and metastasis in PDAC. As a consequence, no good new therapeutic targets have been identified for the cancer in three decades. Despite active research in this field, standard chemotherapy remains the primary treatment available for PDAC, and survival rates are under 5% after a year. Continue Reading
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