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The BRACAnalysis test detects
mutations in the BRCA1 and BRCA2 genes.
Deleterious mutations in these genes have been determined
to predispose mutation carriers to hereditary breast and
ovarian cancer. Genetic testing is most helpful if
the person in the family who is affected with cancer pursues
testing first. This helps in the interpretation of test results.
We strongly encourage that all patients seeking this test
be referred to the Center for Cancer Risk Assessment to receive
counseling and an informed consent process that complies
with applicable state requirements. (For
more information about these Massachusetts state law requirements,
please see the FAQ for Professionals.) Who
should be considered:
- Patients who are diagnosed with breast cancer under the age of 40.
- Patients diagnosed with ovarian cancer at any age.
- Patients with breast cancer diagnosed under the age of 50 with a relative with breast or ovarian cancer.
- A family with three individuals diagnosed with breast cancer (same lineage).
- Patient diagnosed with breast (under age 50) or ovarian cancer (any age) that is of Ashkenazi Jewish descent.
- Personal or family history breast cancer in a male.
Please note that these are guidelines and should not be used as strict criteria.
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