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Peter M. Sadow, MD, PhD

Department of Pathology


  • Cancer Center
  • Head & Neck Cancers
  • Parathyroid Tumors
  • Thyroid Tumors
  • Adrenal Tumors
  • Endocrine Tumors
  • Genitourinary Oncology
Clinical Interests
Endocrine pathology
Head and Neck Pathology
Genitourinary pathology
Frozen Section Pathology
Boston: Massachusetts General Hospital
Medical Education
Ph.D, University of Chicago
MD, University of Chicago Pritzker School of Medicine
Residency, Brigham and Women's Hospital
Fellowship, Brigham and Women's Hospital
Board Certifications
Anatomic Pathology, American Board of Pathology
Patient Age Group
Accepting New Patients


Assistant in Pathology 
Massachusetts General Hospital

Assistant Professor in Pathology
Harvard Medical School

Associate Director
Head and Neck Pathology

Associate Director for Anatomic Pathology Training
Pathology Residency Program

Dr. Sadow's clinical and research interests involve endocrine pathology, studying the mechanisms of endocrine carcinogenesis through translational studies involving the proteomics and genomics of endocrine neoplasms, primarily of the thyroid and adrenal glands. Dr. Sadow also has interests in salivary gland tumors and tumors of the kidney.


Endocrine tumors present a particularly difficult challenge for both pathologists and clinicians in that they are often remarkably benign-appearing under the microscope. Clearly, when they are horrifically malignant, they are horrifically malignant, but often, in the worlds of endocrine pathology and clinical medicine, the biggest tip-off to the level of malignancy is metastasis. Thus, classifying these tumors at an earlier stage in order to both risk stratify patients as well as to develop markers with a better molecular understanding of these neoplasms is the current focus of the field.

We have a very nice working knowledge of some of the molecular defects involved in the biology of thyroid neoplasms, such as mutations in BRAF, RET, beta catenin, PTEN and p53. We also have some functional understanding of these tumors through translocations, such as RET-PTC and PAX8-PPARgamma, the types of functional abnormalities first seen in hematopoietic malignancies. In tumors of the adrenal medulla and paraganglia, we have seen these arise in high probability in association with cancer syndromes, such as MEN (multiple endocrine neoplasia), VHL (Von Hippel Lindau), and Familial Paragangliomatosis (FP). These syndromes are also associated with known mutations in RET (MEN), VHL (VHL) and SDH (FP) genes.

However, for as much as we know, we still are stymied in our ability to predict which of these tumors will become malignant, which will metastasize, and which will ultimately kill the patient, or even more puzzling, which will do absolutely nothing whatsoever if left alone. So, in this, we have a conundrum. It's a classification problem, it's a treatment problem, and it's a challenge for those with an interest to forward the field diagnostically and in the basic understanding of the pathophysiology of endocrine neoplasia.

Pathology Associates
55 Fruit Street
Boston, MA 02114-2696

Phone: 617-573-3159
Fax: 617-543-3389

Pathology Associates
55 Fruit Street
Boston, MA 02114-2696

Phone: 617-573-3159
Fax: 617-543-3389

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