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Tracy Todd (Tracy) Batchelor, MD, MPH

Executive Director, Stephen E. and Catherine Pappas Center for Neuro-Oncology

Director, Division of Neuro-Oncology, Department of Neurology

Professor of Neurology, Harvard Medical School

  • Phone: 617-724-8770
Departments
Department of Neurology

Specialties

  • Cancer Center
  • Neuro-Oncology (Brain)
Clinical Interests
Primary Nervous System Tumors
Lymphomas of the nervous system
Locations
Boston: Massachusetts General Hospital
Medical Education
MD, Emory University Hospitals
MPH, Harvard School of Public Health
Residency, Massachusetts General Hospital
Fellowship, Memorial Hospital for Cancer and Allied Diseases
Board Certifications
Neurology, American Board of Psychiatry and Neurology
Gender
Male
Patient Gateway
Yes, learn more
Patient Age Group
Adult
Accepting New Patients
Yes

BiographyDr. Tracy Batchelor received his undergraduate and medical degrees from Emory University as well as graduate degrees from Harvard University. He completed training in internal medicine at Yale-New Haven Hospital, neurology at Massachusetts General Hospital and neuro-oncology at Memorial Sloan-Kettering Cancer Center. He served as the chief resident in neurology in his final year of residency training at Mass General.  He joined the professional staff at Mass General in 1996 and served as Director of the Neuro-Oncology Fellowship Training Program from 1996-2006.  He has served as Executive Director of the Stephen E. and Catherine Pappas Center for Neuro-Oncology and Chief of the Division of Neuro-Oncology at Mass General Cancer Center since 2001.  He is currently a Professor of Neurology at Harvard Medical School.

Dr. Batchelor's research interests include the development of novel targeted therapeutics for glioblastomas and other primary tumors of the central nervous system.

Dr. Batchelor's main clinical interests include management of patients with primary tumors of the central nervous system including high-grade gliomas (glioblastoma, anaplastic astrocytoma, anaplastic oligodendroglioma, anaplastic ependymoma), low-grade gliomas (astrocytoma, oligodendroglioma, ependymoma), and primary CNS lymphomas.

ResearchA major emphasis of my research has been the development and implementation of experimental therapeutics for glioblastomas with an emphasis on targeted drugs. These studies serve as the basis of my NIH grants and all of my investigator-initiated trials include correlative biospecimen and imaging studies in collaboration with multiple HMS investigators. Our studies of cediranib, a pan-vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor have led to important insights regarding the mechanism of action of VEGF inhibitors in glioblastomas. My initial NCI-funded study of cediranib in recurrent glioblastoma has led to additional studies including an R01-funded phase Ib/II study in newly diagnosed glioblastoma.

Another component of my clinical research has focused on clinical investigations and therapeutic trials in primary central nervous system lymphoma (PCNSL). I have served as principal investigator for institutional as well as NCI-sponsored multi-institutional trials of PCNSL. I am also the co-founder and co-chair of the International PCNSL Collaborative Group (IPCG), an international, multidisciplinary group of 120 investigators from 15 countries with research interests in this disease. I serve as the PI of an NCI-sponsored R13 grant that funds the annual IPCG meeting and I have led or participated in multiple international studies within this group. I am the editor of the only textbook dedicated exclusively to CNS lymphoma, which will be published in a 2nd edition in 2010.

Publications

View my most recent publications at PubMed


1. Batchelor TT, Betensky RA, Esposito JM, Pham L, Dorfman MV, Piscatelli N, Jhung S, Rhee D, Louis DN.  Age-dependent prognostic effects of genetic alterations in glioblastoma.  Clin Cancer Res 2004; 10:  228-233

2. Batchelor TT, Carson K, O'Neill A, Alavi J, New P, Grossman SA, Hochberg F, Priet R for the NABTT CNS Consortium.  The treatment of primary central nervous system lymphoma (PCNSL) with methotrexate and deferred radiotherapy: NABTT 96-07.  J Clin Oncol 2003; 21:  1044-1049 

3. Batchelor TT, Sorensen AG, di Tomaso E, Zhang W-T, Duda DG, Cohen KS, Kozak KR, Cahill DP, Chen P-J, Zhu M, Ancukiewicz M, Mrugala M, Plotkin S, Drappatz J, Louis DN, Ivy P, Scadden DT, Benner T, Loeffler JS, Wen PY, Jain RK.  AZD2171, a pan-VEGF and PDGF receptor tyrosine kinase inhibitor normalizes tumor vasculature and alleviates edema in glioblastoma patients.  Cancer Cell 2007; 11:  83-95

4. Gerstner ER, Yip S, Wang DL, Louis DN, Iafrate AJ, Batchelor TT. MGMT methylation is a prognostic biomarker in elderly patients with new diagnosed glioblastoma. Neurology 2009; 73: 1509-1510 

5. Batchelor TT, Duda DG, di Tomaso E, Ancukiewicz M, Plotkin SR, Gerstner E, Eichler AF, Drappatz J, Hochberg FH, Louis DN, Cohen KS, Chea H, Exarhopoulos A, Loeffler JS, Moses MA, Ivy P, Sorensen AG, Wen PY, Jain RK.  Phase II study of cediranib, an oral pan-VEGF receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma.  J Clin Oncol 2010; 28: 2817-2823

Neurology Bicentennial Celebration, 2011 Part II

Neurology Bicentennial Celebration, October 13, 2011. Clinical and research presentations on ALS, Stroke, Alzheimer’s Disease, and Parkinson’s Disease

Neurology Bicentennial Celebration 2011 II HD

Neurology Bicentennial Celebration, October 13, 2011. Clinical and research presentations on Huntington’s Disease, Epilepsy, and Neuro-Oncology.

Supporting brain cancer research

MGH Hotline 12.10.10 When her father John was diagnosed with a glioblastoma in June 2009, 10-year-old Elana Sargent wanted to find a way to help.

In General awards and honors 1.28.11

MGH Hotline 1.28.11 In General

Imaging studies may predict tumor response to anti-angiogenic drugs

Advanced imaging techniques may be able to distinguish which patients' tumors will respond to treatment with anti-angiogenic drugs and which will not.

Pappas Center for Neuro Oncology
55 Fruit Street
Boston, MA 02114

Phone: 617-724-8770
Fax: 617-724-8769

Pappas Center for Neuro Oncology
55 Fruit Street
Boston, MA 02114

Phone: 617-724-8770
Fax: 617-724-8769

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