David N. Louis, MD

Louis Lab

“Elucidating the molecular basis of glioma formation impacts both diagnostic and therapeutic aspects of clinical neuro-oncology…”

Overview

David N. Louis, MD

Benjamin Castleman Professor of Pathology, Harvard Medical School
Pathologist-in-Chief, Massachusetts General Hospital

Pathology Service
Massachusetts General Hospital
55 Fruit Street (WRN-2)
Boston, MA 02114

Overview

 Over the past 25 years, we have demonstrated alterations characteristic of specific glioma subtypes and grades. We originally demonstrated that molecular genetic analysis could be used to define clinicopathologically relevant subsets of glioblastomas, and then showed that molecular genetic alterations are powerful predictors of therapeutic response and survival in patients with anaplastic oligodendrogliomas and in other oligodendroglial tumors. These findings have already led to incorporation of molecular diagnostic testing around the world for these parameters. Work over the past few years has been directed toward incorporating molecular testing into the World Health Organization Classification of Central Nervous System Tumors, a process directed by Dr. Louis, and toward making molecular diagnostics a practical and routine part of brain tumor diagnosis. The lab has also demonstrated that glioblastomas treated with the alkylating agent temozolomide (which is now the standard of care for such cases) frequently inactivate mismatched repair genes, leading to more rapid growth during therapy and to therapeutic resistance, and has worked collaboratively on epigenetic and single-cell studies of high-grade gliomas.

Read more about the Louis Lab from the Center for Cancer Research Annual Report and the Pathology Basic Science Research Brochure.

 

Geometric shapes with fluorescense imaging picturesPathology research report

Group Members

David Louis
R.K. Narayanan
Sophie Shnaper
Mario Suva
James Kim
Ben Levin

Research Positions

Read about and apply for residency, fellowship and observership programs at http://www.massgeneral.org/pathology/training/.

Apply for temporary positions (summer interns)  through the Bulfinch Temporary Service Web site at http://www.massgeneral.org/careers/temporary.aspx.

All applicants should register with the Mass General Careers Web site at http://www.massgeneral.org/careers/viewall.aspx.

 

Selected Publications

Selected Publications

Bibliography of David N. Louis via PubMed

Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds.).  World Health Organization Histological Classification of Tumours of the Central Nervous System.  Lyon: International Agency for Research on Cancer, 2016.

Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW. The 2016 WHO classification of tumours of the central nervous system: a summary.  Acta Neuropathol. 2016; 131(6):803-820.

Tanboon J, Williams EA, Louis DN.  The diagnostic use of immunohistochemical surrogates for signature molecular genetic alterations in gliomas.  J Neuropathol Exp Neurol. 2016; 75:4-18.

Louis DN. Perry A, Burger P, et al.  International Society of Neuropathology-Haarlem consensus guidelines for nervous system tumor classification and grading.  Brain Pathol. 2014; 24:429-435.

PubMed Article

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557632/

 

 

 

 

 

 

 

Contact

Contact Us

Louis Laboratory

Massachusetts General Hospital

Warren 225 Boston, MA 02114
  • Phone: 617-726-2966
  • Fax: 617-726-7533

Email: dlouis@partners.org

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