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Our multidisciplinary team of cancer specialists provides comprehensive, individually tailored treatment for children and adults with soft tissue sarcoma – cancers arising in tissue such as muscle, tendon, cartilage, fat, blood vessels, and nerves. Because sarcoma is so rare, it is important to seek treatment from experts with extensive experience in diagnosing and managing these rare cancers. Our program is one of the oldest, largest, and most experienced sarcoma treatment programs in the world.
Among the types of soft tissue sarcomas treated here are:
At the Center for Sarcoma and Connective Tissue Oncology, we offer cutting edge care and innovative surgical, medical oncology, and radiation oncology treatments designed to eradicate the tumor, prevent local recurrence, improve survival and optimize limb function.
Our surgeons are experienced in resecting tumors and reconstructing defects. We are active participants in a national clinical trials network that allows us to bring new treatments to our patients as quickly as possible. We are one of only a few centers in the Unites States that include proton beam therapy among our therapeutic offerings in addition to state-of-the-art surgery and targeted chemotherapy.
Our musculoskeletal pathologists sub-specialize in soft tissue tumors. They use state-of-the-art morphologic and molecular techniques to provide diagnostic information that helps the treatment team develop the most effective therapeutic strategies for each patient’s unique cancer. This includes precise diagnosis, tumor characterization, and staging (a determination of whether the cancer has spread). Molecular analysis techniques help to identify biologic markers that further guide therapy.
During surgery, pathologists carefully analyze the tumor to help ensure that the surgeons completely remove the tumor with negative margins (no surrounding cancer).
Our radiologists use advanced imaging technologies to provide diagnostic and staging information. Technologies include:
We offer the full range of chemotherapeutic agents, including angiogenesis inhibitors and molecularly targeted agents to treat patients with and of the over 50 sub-types of sarcoma. Through our clinical trials program, we, are able to offer many new investigational medications for appropriately selected patients. Research conducted at our Cancer Center and elsewhere is leading to better understanding of the genetic basis of soft tissue sarcomas and pointing the way to new treatment strategies. Additional research is focused on the problem of reverse drug resistance in sarcoma.
Our orthopaedic oncology and spine surgeons are expert in the most advanced techniques, including computer-navigated surgery. They are leaders in the resection of small to massive tumors and in the development of limb preservation techniques, including the use of modern prostheses for reconstruction. Today, 90 to 95 percent of patients who would have required an amputation 30 years ago can be safely treated with limb-sparing techniques, with the goal of moving about free of pain or assistive devices.
Our radiation oncologists offer a range of therapies designed to shrink and destroy tumors while protecting normal tissue. Advanced technologies include:
Learn more about radiation therapy.
Research conducted at Massachusetts General Hospital Cancer Center and other cancer centers is leading to better understanding of the genetic basis of soft tissue sarcomas. Our investigators are focused on identifying genetic mutations associated with sarcoma and biologic markers that predict tumor behavior. Findings will help shape new treatment strategies. Our laboratory researchers are also developing novel strategies to reverse drug resistance in sarcoma, supported in part by the Cancer Center's world-renowned archive of sarcoma tissue and associated clinical information. Results are being used to design new clinical trials.
Our team approach ensures that every patient benefits from an individualized, coordinated and compassionate treatment plan, with care provided by leading experts from many specialties. We consider patients and their family and friends involved in their care to be part of this team. Your care team may include:
Your team will develop and implement an integrated personalized care plan for you. Depending on the stage and other characteristics of your cancer, the treatment may include surgery, chemotherapy, radiation therapy, or a combination of these therapies. The team meets weekly in Sarcoma Conference to monitor treatment and ensure seamless communication and coordination of care.
There are different types of bone cancers, which are typically defined as a malignant (cancerous) tumor of the bone that destroys normal bone tissue.
Through our clinical trials program, we are able to offer many new, investigational medications for appropriately selected patients. We participate in the Massachusetts General Hospital Phase I program, which offers additional Phase I trials for patients with advanced solid tumors.
Phone: (617) 726-5130
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