THE CENTER FOR CANCER RESEARCH
The unique strengths of the Center for Cancer Research (CCR) are the exceptional quality of its faculty and the ways in which the CCR's basic scientists collaborate with Mass General’s leading oncologists, surgeons, radiologists, pathologists, and other health care professionals to advance the frontiers of cancer medicine.
Read the Center for Cancer Research's 2014 Annual Report
- Postdoctoral Research Fellowship positions
- Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism.
- Engineered CRISPR-Cas9 nucleases with altered PAM specificities.
- Lineage conversion induced by pluripotency factors involves transient passage through an iPSC stage.
- Hypoxia drives transient site-specific copy gain and drug-resistant gene expression.
- A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity.
- The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.
- Sridhar Ramaswamy, MD was elected a 2015 MGH Research Scholar.
- Shyamala Majeswaran PhD was awarded the 2015 Martin Prize for Excellence in Basic Research
- YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression.
- RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer.
- Inhibition of mutant EGFR in lung cancer cells triggers SOX2-FOXO6-dependent survival pathways.
- Clinical acquired resistance to RAF inhibitor combinations in BRAF-mutant colorectal cancer through MAPK pathway alterations.
- PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation.
- Tunable nanostructured coating for the capture and selective release of viable circulating tumor cells.
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