THE CENTER FOR CANCER RESEARCH
The unique strengths of the Center for Cancer Research (CCR) are the exceptional quality of its faculty and the ways in which the CCR's basic scientists collaborate with Mass General’s leading oncologists, surgeons, radiologists, pathologists, and other health care professionals to advance the frontiers of cancer medicine.
Read the Center for Cancer Research's 2014 Annual Report
- Hypoxia drives transient site-specific copy gain and drug-resistant gene expression.
- A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity.
- The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.
- Sridhar Ramaswamy, MD was elected a 2015 MGH Research Scholar.
- Shyamala Majeswaran PhD was awarded the 2015 Martin Prize for Excellence in Basic Research
- YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression.
- RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer.
- Inhibition of mutant EGFR in lung cancer cells triggers SOX2-FOXO6-dependent survival pathways.
- Clinical acquired resistance to RAF inhibitor combinations in BRAF-mutant colorectal cancer through MAPK pathway alterations.
- PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation.
- Tunable nanostructured coating for the capture and selective release of viable circulating tumor cells.
- Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors.
- Lysine Demethylase KDM4A Associates with Translation Machinery and Regulates Protein Synthesis.
- A Coding Single Nucleotide Polymorphism in Lysine Demethylase KDM4A Associates with Increased Sensitivity to mTOR Inhibitors.
- Genetic and epigenetic fine mapping of causal autoimmune disease variants.
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