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Center for Engineering in Medicine
The overarching theme in BioMEMS and Nanoscale Engineering group at the Center for Engineering in Medicine is to develop miniaturized platforms to modulate and monitor cell and tissue behavior in the context of normal and pathological states.
•Mehmet Toner, PhD•Martin Yarmush, MD, PhD•Ron Tompkins, MD, ScD •Daniel Irimia, MD, PhD•Shannon Stott, PhD•O. Berk Usta, PhD•Ken Kotz, PhD•Rohit Jindal, PhD
The Center for Engineering in Medicine (CEM) is a leading institution in the fields of BioMEMS and Nanoscale Engineering, credited with many innovative "firsts," and with training a whole generation of young investigators who have initiated their own academic research programs.
Among our notable developments is the “Living Cell Array” (LCA), a powerful real-time gene expression tool consisting of cells expressing GFP reporter genes in a microfluidic format, which allows simultaneous dynamic profiling of transcription factors regulating the inflammatory and other responses.
We have also developed multiple microfluidic technologies for rare cells sorting, on-chip cytometry and cell motility chips with applications in burns and trauma, HIV/AIDS, cancer and global health.
Other major efforts have included unique bone marrow and tumor niche microsystems for analytical and therapeutic applications; various single cell technology formats (e.g. arrays and droplet-based techniques); and several dynamic tissue systems, such as “brain-on-a chip,” “allergy-on-a-chip” and “liver sinusoid-on-a-chip”.
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