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Center for Engineering in Medicine
The Global Health Group at the Center for Engineering in Medicine is working to design novel diagnostic tools for diseases such as tuberculosis and HIV/AIDS.
•Mehmet Toner, PhD•Daniel Irimia, MD, PhD•Martin Yarmush, MD, PhD•Ron Tompkins, MD, ScD •Rebecca D. Sandlin, PhD
The focus of this research group is to design novel diagnostic tools for diseases of importance in Global Health, such as HIV/AIDS, tuberculosis and typhoid fever. Although several diagnostic assays exist today for these diseases, these tools are either too expensive or require an efficient infrastructure that is not available in resource-poor settings.
Our goal is to develop point-of-care (POC) diagnostic devices that will enable the decentralized delivery of health care to those who need it. In recent years, our group has developed a microfluidics-based CD4+ T-cell counter to aid in HIV/AIDS monitoring.
Specifically, the microchip uses a cell affinity chromatography approach under differential shear flow to specifically isolate CD4+ T lymphocytes with high efficiency directly from 10 microlitres of unprocessed, unlabeled whole blood. This device is currently undergoing commercialization.
In order to complement the CD4 counter, current efforts in the laboratory focus on the development of a device for HIV viral load determination from whole blood, which will serve in disease monitoring as well as infant diagnosis of HIV infection.
In addition, in the past two years, we have significantly expanded our team and efforts to contribute to the development of tools to control the current tuberculosis epidemic. Representative project descriptions are provided below.
Ongoing research projects:
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