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Center for Engineering in Medicine
The Center for Engineering in Medicine is conducting research into Tissue Engineering and Regenerative Medicine.
• Basak Uygun, PhD • Biju Parekkadan, PhD• O. Berk Usta, PhD •Marianna Bei, PhD• Rohit Jindal, PhD• Martin Yarmush, MD, PhD• Mehmet Toner, PhD• Ron Tompkins, MD, ScD
The focus of our group is to engineer therapies for liver regenerative medicine. Our group was the first to establish the whole liver engineering approach to create grafts that are transplantable and may potentially serve as alternatives to donor livers.
We use donor livers that are not found suitable for transplantation because of poor quality or excessive damage during storage, and remove the cells by a process called perfusion decellularization.
After the removal of the dead cells, the resulting extracellular matrix scaffolding is used to recreate the native liver architecture using fresh and healthy liver cells.
Having established the technology in a small animal model, our current efforts focus on scaling up to human livers, regenerating liver tissue from human induced pluripotent cells and developing techniques that will extend the in vivo viability of the recellularized livers.
We are also working on in vivo decellularization techniques using irreversible electroporation of the liver as an approach to precondition the organ for cell transplantation and stimulation of resident stem cells for regeneration of healthy tissue.
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