• Mohamed Aburawi, MBBS

    Mohamed Aburawi, MBB

    Education:
    MBBS, Al Margeb University Faculty of Medicine, Libya, 2014

    Contact:
    Phone: 857-928-0727
    Contact by email

    Research:
    Using ex vivo machine perfusion systems, I'm working on assessing and potentially reviving discarded donor livers and kidneys that have been deemed unsuitable for transplantation. My work also focuses on stimulating ex-vivo liver graft regeneration using normothermic perfusion.


  • Berent Aldikacti, MD

    Berent Aldikacti, MD

    Education:
    MD, Yeditepe University, 2015

    Contact:
    Phone: 617-383-3838
    Contact by email

    Research:
    My main research goals include studying blood-based biomarkers, such as extracellular vesicles and circulating tumor cells, role in early detection and prognosis of Glioblastoma Multiforme patients, using microfluidic platforms and high-throughput imaging. Furthermore, I am using two and three-dimensional in vitro tumor models to understand their effects on the biogenesis of extracellular vesicles.


  • Beyza Bulutoglu, PhD

    Beyza Bulutoglu, PhD

    Education:
    PhD, Chemical Engineering, Columbia University, New York, 2017
    MS, Biomedical Engineering, Yale University, New Haven, 2011
    BS, Chemical Engineering, Bogazici University, Turkey, 2010

    Contact:
    Contact by email

    Research:
    During my masters studies, my research focused on the synthesis of theranostic nanoparticles for dual drug-delivery/imaging purposes. My doctoral thesis work concentrated on basic and applied aspects of protein engineering as well as molecular biology, focusing specifically on engineering different biomolecular interfaces for biotechnology applications, such as proteinaceous hydrogel formation. At CEM, I am using my background in protein and genetic engineering for medically oriented studies. My current research activities are focused on elucidating drug-drug interactions at the transcriptional level in hepatocytes and constructing recombinant bioactive peptides for tissue engineering purposes.


  • Julie Devalliere, PhD

    Julie Devalliere, Ph

    Education:
    PhD, Cell Biology, University of Nantes, France 2011
    MS, Bioengineering, Polytech Institute Clermont-Ferrand, France, 2006

    Contact:
    Phone: 774-208-7142
    Contact by email

    Research:
    I am a bioengineer with the goal of conducting a research program on wound healing process and tissue regeneration. I have a broad background in bioengineering as well as in cell biology, with specific training and expertise in vascular biology. As a postdoctoral fellow at Yale University, I laid the groundwork for the proposed research by developing an efficient nanoparticle-based therapy to promote angiogenesis in implantable 3D protein gel.

    This engineered scaffold has been shown to accelerate and improve the formation of functional microvascular networks offering a promising strategy to overcome the lack of vascularization observed in patients in need of replacement tissues. I am currently developing new composite skin substitutes that incorporate nanoparticle-based delivery systems for wound healing therapies. I investigate various strategies for protecting bioactive molecules from harsh wound environment and controlling spatio-temporal release of bioactive peptides into matrix-based and cell-based skin substitutes.


  • Felix Ellett, PhD

    Felix Ellett, PhD

    Education:
    PhD, Medical Biology, the Walter & Eliza Hall Institute, 2011
    BS (Hons), the University of Melbourne, 2006

    Contact:
    Phone: 617-724-3209
    Contact by email

    Research:
    My research is centered on achieving a deeper understanding of the innate immune response during inflammation and infection, with a particular focus on sepsis. Using microfluidic technologies, I study alterations in immune cell activity that occur during sepsis. These assays can be used both as a diagnostic tool, and to provide insight into the fundamental biology that underpins sepsis development in at-risk patients.


  • Fermin M. Fontan, MD

    Fermin M. Fontan, MD

    Education:
    MD, University of Buenos Aires Medical School, 2012 PG-1 General Surgery, Johns Hopkins University, 2014
    PG-2 General Surgery, Johns Hopkins University, 2015
    PG-3 General Surgery, STEMC, Tufts University, 2016

    Contact:
    Phone: 443-857-1115
    Contact by email

    Research:
    I work in Dr. Markmann’s lab and my focus is on Ex-Vivo Organ Perfusion. We perform human kidney and liver perfusions at hypothermic, sub-normothermic and normothermic temperatures using different perfusates such as blood, synthetic oxygen carriers and enriched media to foster organ preservation, energy stores recovery, repair, and assessment of discarded grafts. Our goal is to decrease the enlarging disparity gap between donors and recipients by giving a more efficient use of marginal grafts trying to target those organs that are currently being discarded. We are in the process of receiving approval to start clinical trials and move these technologies into a clinical phase.


  • Galit H. Frydman, DVM

    Galit H. Frydman

    Education:

    Postdoctoral Fellow, Center for Surgery, Innovation & Bioengineering, MGH, 2014-Current
    Postdoctoral Fellow, Division of Comparative Medicine, MIT, 2013-Current
    Fellow, Translational Fellows Program, MIT, 2015-2016
    PhD Candidate, Biological Engineering, MIT, Expected 2018
    DVM, University of Florida College of Veterinary Medicine, 2013
    BS, Biological Sciences, Carnegie Mellon University, 2007

    Contact:
    Phone: 617-371-4882
    Contact by email

    Research:
    My research currently focuses on both the exploration of biological mechanism and the design and development of point-of-care diagnostics in the area of immune-thrombosis, with special interest in coagulation and sepsis. My veterinary and biomedical engineering training allows me to incorporate a "one health" initiative, benefiting both people and animals.


  • A. Aslihan Gokaltun, PhD

    A. Aslihan Gokaltun,

    Education
    PhD, Hacettepe University, 2014
    MS, Hacettepe University, 2009
    BS, Hacettepe University, 2007

    Contact:
    Phone: 617-949-0685
    Contact by email

    Research:
    Poly(dimethylsiloxane) (PDMS) is one of the most widely used materials in the fabrication of microfluidic devices. A major drawback of this material is its hydrophobicity and fast hydrophobic recovery after surface hydrophilization.

    This results in significant non-specific adsorption of proteins as well as small hydrophobic molecules such as therapeutic drugs limiting the utility of PDMS in biomedical microfluidic circuitry. Accordingly, I’m working on a very practical alternative to PDMS by employing copolymers as additives by one-step in-mould modification method to create protein repellent and hydrophilic PDMS surfaces. This way we hope to improve its utility and expand its use in biomedical applications.


  • Dongli Guan, PhD

    Dongli Guan, PhD

    Education:
    PhD, Biological Sciences, Louisana State University, 2011
    BS, Biotechnology, Huazhong Agricultural University, 2004

    Contact:
    Phone: 617-722-3000 (ext. 4195)
    Contact by email

    Research:
    Engineering synthetic materials and immunological receptors for cancer immunotherapy. We are also developing novel genetic probes for capturing and multiplex cloning of coding and non-coding regions from human cDNA and genomes. These probes can be used for functional study of various genetic loci of interest, such as cancer hot spots.


  • Alex Hopke, PhD

    Alex Hopke, PhD

    Education:
    PhD, Microbiology, The University of Maine, 2016
    BS, The University of Maine, 2010

    Contact:
    Phone: 978-758-0692
    Contact by email

    Research:
    Using a micro-spotting machine, I am examining the behaviors of immune cells during interactions with microbes, particularly the “neutrophil swarming” behavior. The role of neutrophil swarming during injury and infection in humans is poorly understood. Through our investigations we hope to both gain insight into the importance of swarming in humans and to apply this knowledge to develop ways to assist patients who may have swarming defects.


  • Yong Hu, PhD

    Yong Hu, PhD

    Education:
    PhD, Wuhan University, 2012
    BS, Central China Normal University, 2006

    Contact:
    Phone: 857-600-1207
    Contact by email

    Research:
    I’m interested in applying molecular biology, cell biology and bioengineering techniques to test novel therapies approach and address pressing biological problems in the medical field, such as tissue engineering, gene therapy and stem cell therapy. My current project focus on developing a novel gene-activated matrix (GAM) and genetically modified MSCs for tissue regeneration, including wound healing, spinal cord injury, and chondrogenesis.


  • Maria Jaramillo, PhD

    Maria Jaramillo, PhD

    Education:
    PhD, Bioengineering, University of Pittsburgh, 2013
    BS, Biomedical Engineering, Florida International University, 2006

    Contact:
    Phone: 617-371-4426
    Contact by email

    Research:
    My research is focused in the development of tissue engineering-based artificial livers using decellularized liver matrix. Specifically, I am investigating cell-extracellular matrix (ECM) interactions in hepatic differentiation of human pluripotent stem cells, and developing approaches for recellularization of liver scaffolds using pluripotent stem cell derived cells. In addition, we are developing strategies for reendothelialization of decellularized liver scaffolds in order to achieve hemocompatibility in artificial liver grafts.

    Furthermore, I am working in the design of pre-vascularized skin grafts with controlled capillary network geometry that will promote graft integration for the treatment of treatment for burn-related injuries.


  • Mehdi Jorfi, PhD

    Mehdi Jorfi, PhD

    Education:
    Postdoc, Massachusetts Institute of Technology, 2016
    PhD, Bioengineering, University of Fribourg, 2014

    Contact:
    Phone: 617-724-1053
    Contact by email
    Website: www.mehdijorfi.com

    Research:
    Neurological disorders represent a significant proportion of diseases burden and are of great medical importance, but the complexity of the human brain makes it difficult to closely model such diseases and to study experimentally. We address the lack of physiologically relevant human brain model by developing and validating a three-dimensional organotypic brain model to better recapitulate the in-vivo organ and the complex interactions between different cell types in the human brain. Such model offers a relevant and useful platform for the neurodegenerative disorders and diseases such as Alzheimer’s disease, and has the potential to further our understanding of the central nervous system pathology, and to accelerate the screening for novel therapeutic drugs.


  • Kaja Kaastrup, PhD

    Kaja Kaastrup, PhD

    Education:
    PhD, Massachusetts Institute of Technology, 2015
    MS, CEP, Massachusetts Institute of Technology, 2013
    BS, University of California, Berkeley, 2009

    Contact:
    Contact by email

    Research:
    My research is focused on the development of point-of-care diagnostic tools for tuberculosis. We are working to apply microfluidic technologies to the rapid isolation of Mycobacterium Tuberculosis from blood without a reliance on specific biomarkers. 


  • Young Bok (Abraham) Kang, PhD

    Young Bok Kang

    Education:
    PhD, Mechanical Engineering and Mechanics, Drexel University, 2015
    MS, Chemical Engineering, Seoul National University, 2004
    BS, Chemical Engineering, Korea University, 2001

    Contact:
    Phone: 267-648-0385
    Contact by email

    Research:
    My research interests lie at the intersection between microfabrication/microfluidics and biotechnology/bioengineering including bio-inspired engineering organ models, healthcare diagnostic devices, biomechanics and biosensors. Specifically, I am studying the development of novel microfluidic platforms for actively controlled in-vitro liver zonation. The developed liver model would be used for liver zonation study, disease research, and drug screening applications.


  • Safak Mert, PhD

    Safak Mert, PhD

    Education:
    PhD, Ankara University, Biotechnology Institute, 2013
    MSc, Hacettepe University, Natural Sciences Institute, 2008
    BSc, Hacettepe University, Biology Department, 2003

    Contact:
    Contact by email

    Research:
    I’m currently working on identification of liver metabolic changes throughout the period of ischemia, reperfusion and subnormothermic machine perfusion (SNMP). Using these information, we hope to develop new perfusion techniques and improve both the quality of organ preservation and time of storage. Our final goal is reconditioning of ischemia injured organs and use them for transplantation


  • Baris R. Mutlu, PhD

    Baris R. Mutlu, PhD

    Education:
    PhD, Mechanical Engineering, University of Minnesota, 2016
    MS, Mechanical Engineering, Middle East Technical University / Turkey, 2010
    BS, Mechanical Engineering, Middle East Technical University / Turkey, 2007

    Contact:
    Phone: 617-643-4545
    Contact by email


  • Masayuki Otawara, MD

    Masayuki Otawara

    Education:
    MD, Okayama University, Japan 2005

    Contact:
    Phone: 617-722-3000
    Contact by email

    Research:
    I am a scientist trained as an acute care physician and my research focuses on studying neutrophil migration and NETs (Neutrophil Extracellular Traps) using microfluidic platforms. Specifically, I validate a microfluidic assay for predicting, diagnosing, and monitoring critical states. Another is to develop more effective treatments for burn injury to minimize secondary wound necrosis, and for sepsis to suppress secondary organ injuries.


  • Maedeh Roushan, PhD

    Maedeh Roushan, PhD

    Education:
    PhD, Physics, Bio-Physics, North Caroline State University, 2015
    MSc, Physics, Gravity and Cosmology, University of Tehran, 2011
    BSc, Physics, Solid State, University of Mazandaran, 2008

    Contact:
    Phone: 617-724-5336
    Contact by email

    Research:
    I am working on the interactions between Neutrophil Extracellular Traps (NETs) with whole blood in microfluidic systems. The gold of my research is to evaluate the utility of a novel biomarker in the context of septic shock in patients. Since septic shock is the most common cause of death in intensive care units, hopefully we can identify those patients at the early stage of disease with our new biomarker.


  • Shannon N. Tessier, PhD

    Shannon N. Tessier,

    Education:
    PhD, Biology/Biochemistry, Carleton University, 2014
    MSc, Biology Carelton University, 2010
    BSc, Careton University, 2007

    Contact:
    Phone: 617-952-9192
    Contact by email

    Research:
    Using inspiration from nature, I am developing novel preservation methods aimed at increasing the length of time transplantable organs and tissues remain alive ex vivo. I am also creating new strategies for the stabilization of whole blood and its components for microfluidics, molecular diagnostics and transfusion, and testing new compounds for applications in cryopreservation of primary cells for therapeutics. A common theme across these projects is the control of biological time and promoting the broad dissemination of life-saving technology.


  • Xiao Wang, PhD

    Xiao Wang, PhD

    Education:
    PhD, University of Cincinnati, 2016
    BS, Huazhong University of Science and Technology, 2010

    Contact:
    Phone: 513-484-9685
    Contact by email
    Website: http://albertxiaowang.wixsite.com/xiaowang

    Research:
    My research is focusing on developing in vitro microfluidic assay to study the migration and interaction of immune cells in physiological and pathological conditions.


  • Lindong Weng, PhD

    Lindong Weng, PhD

    Education:
    PhD, Mechanical Engineering, Dailan University of Technology, 2012
    BS, Qingdao Technological University, 2007

    Contact:
    Phone: 617-724-5336
    Contact by email

    Research:
    My research focuses on the biophysics and thermodynamics in biopreservation of living cells, tissues, and organs. One of the projects I am working on is to develop robust methods to cryopreserve Plasmodium sporozoites, the mosquito-stage malaria parasite, which will enable the global dissemination of Plasmodium sporozoites to researchers and eliminate the necessity of transporting live mosquitoes. I am also working on an organ-banking project aimed at preserving human organs over an extended period of time at a high subzero temperature between -4 and -20 °C.


  • Keith Wong, PhD

    Keith Wong, PhD

    Education:
    PhD, Biomedical Engineering, Boston University, 2012
    B. Eng., Mechanical Engineering, University of Hong Kong, 2006

    Contact:
    Contact by email

    Research:
    My research goal is to develop enabling technologies for blood-based liquid biopsy. To this end, I am applying principles of tissue engineering to stabilize blood ex vivo for rare cell isolation and molecular characterization.


  • Mengjie Wu, PhD

    Mengjie Wu

    Education:
    PhD, Stomatology, Zhejiang University, 2008
    Joint PhD program, Medical College of Georgia, 2007
    MD, DDS, Stomatology, Anhui Medical University, 2003

    Contact:
    Phone: 617-372-4559
    Contact by email

    Research:
    Research area is focus on the MSCs promote the regeneration of cartilage. Our long-term goal is to combine engineered biomaterials and stem cell based therapies to treat osteoarthritis (OA). We are trying to develop intra-articular, injectable, disease-modifying therapies that offer long-term relief from inflammation, and enhance cartilage regeneration.


  • Yunlong Yang, PhD

    Yunlong Yang, PhD

    Education:
    PhD, Entomology, Louisiana State University, 2011
    BS, Huazhong Agricultural University, 2004

    Contact:
    Phone: 617-371-4917
    Contact by email

    Research:
    I'm developing a high-efficient and high-throughput molecular cloning tool, which enables the capture of kilobase-sized fragments in a massively multiplexed reaction for various downstream applications. This tool could be used to clone large DNA fragment (>10 kb) for advancing next generation sequencing or to construct ORF libraries for protein expression screening (i.e. enzymes secreted by human gut microbiome).


  • Frank Yin Yu, MD, PhD

    Frank Yin Yu, MD, Ph

    Education:
    PhD, Biomedical Engineering, The University of Iowa, 2015
    MS, Biomedical Engineering, The University of Iowa, 2012
    MD, Nantong University College of Medicine, 2010

    Contact:
    Address: 51 Blossom St., Boston, MA 02114
    Phone: 319-512-1717
    Fax: 617-573-9471
    Contact by email

    Research:
    Dr. Yu`s research interest is primarily in the area of tissue engineering and in vitro 3D tissue/organ model for drug testing and disease modeling. He specifically focuses on developing gene-activated matrix (GAM) for in situ articular cartilage regeneration, and establishing cellular therapy techniques for osteoarthritis treatment by engineered mesenchymal stromal cells (MSCs). He also aims at developing in vitro model of osteoarthritis using Synthetic Biology and 3D Bio-printing.