Center for Genomic Medicine

The goal of the Massachusetts General Hospital Center for Genomic Medicine (CGM) is the promulgation of the Genomic Medicine Cycle.

The CGM is leading an effort to complete the genomic medicine cycle—from genetic discoveries to mechanism to the clinic—by assessing where genomic medicine will have the greatest impact on human health, and by driving efforts to implement genomic medicine in those areas, at Mass General and beyond.

The cycle is a paradigm for disease research that begins by comparing human phenotypes and genetic variation to identify genes of importance in human disease, then moves on to characterizing the mechanisms by which the underlying DNA differences lead to disease, and is completed when the knowledge gained delivers benefit back to patients in the forms of improved diagnosis, disease management and treatments.

Faculty

Raghu Chivukula, MD, PhD
Assistant Professor of Medicine, Harvard Medical School
Assistant Physician, Department of Medicine, Mass General Brigham

Melina Claussnitzer, PhD
Associate Professor of Medicine, Harvard Medical School
Investigator, Department of Medicine, Mass General Brigham

Susan L. Cotman, PhD
Assistant Professor of Neurology, Harvard Medical School
Assistant in Neuroscience, CGM & Department of Neurology, Mass General Brigham

Mark Daly, PhD
Chief, Analytic and Translational Genetics Unit, Mass General Brigham
Associate Professor of Medicine, Harvard Medical School
Senior Associate Member, Broad Institute

Alysa Doyle, PhD
Associate Professor of Psychiatry, Harvard Medical School
Director of Research, Learning and Emotional Assessment Program, Mass General Brigham
Associate Researcher, Stanley Center for Psychiatric Research

Florian Eichler, MD
Director, Center for Rare Neurological Diseases, Mass General Brigham
Professor of Neurology, Harvard Medical School

Hilary Finucane, PhD
Assistant Professor of Medicine, Harvard Medical School
Assistant in Investigation, Department of Medicine, Mass General Brigham

Jose C. Florez, MD, PhD
Professor of Medicine, Harvard Medical School
Chief of Medicine, Mass General Brigham
Institute Member, Broad Institute

Tian Ge, PhD
Associate Professor of Psychiatry, Harvard Medical School
Assistant Investigator, Department of Psychiatry, Mass General Brigham

James Gusella, PhD
Bullard Professor of Neurogenetics, Harvard Medical School
Director, Center for Neurofibromatosis and Allied Disorders, Harvard Medical School

Stephen J. Haggarty, PhD
Professor of Neurology, Harvard Medical School

Hailiang Huang, PhD
Associate Professor of Medicine, Harvard Medical School
Assistant Investigator, Department of Medicine, Mass General Brigham

Konrad Karczewski, PhD
Associate Professor of Medicine, Harvard Medical School
Investigator, Department of Medicine, Mass General Brigham

Rakesh Karmacharya, MD, PhD
Associate Professor of Psychiatry, Harvard Medical School

W. Taylor Kimberly, MD, PhD
Professor of Neurology, Harvard Medical School
Associate Director, Neuroscience ICU, Mass General Brigham
Chief, Division of Neurocritical Care, Neurology, Mass General Brigham

Ben Kleinstiver, PhD
Associate Professor of Pathology, Harvard Medical School
Kayden-Lambert MGH Research Scholar 2023-2028
Associate Investigator, Pathology, Mass General Brigham

Jong-Min Lee, PhD
Associate Professor of Neurology, Harvard Medical School
Associate Investigator, Department of Neurology, Mass General Brigham

Phil Hyoun Lee, PhD
Associate Professor of Neurology, Harvard Medical School
Associate Investigator, Department of Neurology, Mass General Brigham

Marcy E. MacDonald, PhD
Professor of Neurology, Harvard Medical School
Faculty, Basic Biological Sciences, Harvard Medical School
Non-clinical Staff, Mass General Brigham
Associate Member, Broad Institute

Alicia Martin, PhD
Assistant Professor of Medicine, Harvard Medical School
Assistant Investigator, Department of Medicine, Mass General Brigham

Vamsi K. Mootha, MD
Investigator, Howard Hughes Medical Institute (HHMI)
Professor of Systems Biology and Medicine, Harvard Medical School
Institute Member, Broad Institute

Ricardo Mouro Pinto, PhD
Assistant Professor in Neurology, Harvard Medical School
Assistant Investigator, Department of Neurology, Mass General Brigham

Patricia Musolino, MD, PhD
Associate Professor of Neurology, Harvard Medical School
Co-Director of the Pediatric Stroke & Cerebrovascular Service, Mass General Brigham

Benjamin Neale, PhD
Associate Professor of Medicine, Harvard Medical School
ATGU, Mass General Brigham
Director of Population Genetics, Stanley Center for Psychiatric Research, Broad Institute

Aarno Palotie, MD, PhD
Lecturer, Harvard Medical School
Group Leader, Mass General Brigham

Roy H. Perlis, MD, MSc
Professor of Psychiatry, Harvard Medical School
Vice Chair for Research, Department of Psychiatry, Mass General Brigham

Vijaya Ramesh, PhD
Professor of Neurology, Harvard Medical School

Heidi L. Rehm, PhD, FASMG
Chief Genomics Officer, Department of Medicine, Mass General Brigham
Medical Director, Broad Institute Clinical Research Sequencing Platform
Professor of Pathology, Harvard Medical School
Rappaport MGH Research Institute Endowed Chair

Elise Robinson, ScD
Associate Professor of Psychiatry, Harvard Medical School
Associate Investigator, Department of Psychiatry Mass General Brigham

Jonathan Rosand, MD, MSc
Professor of Neurology, Harvard Medical School
J.P. Kistler Neurologist, Mass General Brigham
Co-Director, Institute for Brain Health, Mass General Brigham
Associate Member, Broad Institute

Kaitlin Samocha, PhD
Assistant Professor of Medicine, Harvard Medical School
Assistant Investigator, Department of Medicine, Mass General Brigham

Richa Saxena, PhD
Professor of Anesthesia, Harvard Medical School
Phyllis and Jerome Lyle Rappaport MGH Research Scholar
Associate Member, Medical and Population Genetics, Broad Institute

Jeremiah Scharf, MD, PhD
Assistant Professor of Neurology, Harvard Medical School
Co-Director, Tourette Association of America Center of Excellence, Mass General Brigham
Co-Chair, Tourette Syndrome Association International Consortium for Genetics

Ihn Sik Seong, PhD
Associate Professor of Neurology, Harvard Medical School
Associate Investigator, Department of Neurology, Massachusetts General Hospital

Brian Skotko, MD, MPP
Associate Professor of Pediatrics, Harvard Medical School
Co-Director, Down Syndrome Program, Mass General Brigham

Susan A. Slaugenhaupt, PhD
Professor of Neurology (Genetics), Harvard Medical School
Investigator, Center for Genomic Medicine, Mass General Brigham

Jordan W. Smoller, MD, ScD
Professor of Psychiatry, Harvard Medical School
Director, Psychiatric and Neurodevelopmental Genetics Unit, Mass General Brigham

Alice Stanton, PhD
Assistant Professor of Neurology, Mass General Brigham

David Sweetser, MD, PhD
Associate Professor of Pediatrics, Harvard Medical School
Chief of Medical Genetics and Metabolism, Mass General Brigham
Co-Director Pitt Hopkins Syndrome Clinic, Mass General Brigham
Mass General Site Director, Undiagnosed Diseases Network

Michael Talkowski, PhD

Professor of Neurology, Harvard Medical School
Director, Center for Genomic Medicine, Mass General Brigham

Miriam Udler, MD, PhD
Associate Professor of Medicine, Harvard Medical School
Attending in Endocrinology, Department of Medicine, Mass General Brigham

James Walker, PhD
Assistant Professor of Neurology, Harvard Medical School
Assistant in Genetics, Mass General Brigham
Associate Member, Broad Institute

Vanessa Wheeler, PhD
Professor of Neurology, Harvard Medical School

Wei Zhou, PhD
Assistant Professor of Psychiatry, Harvard Medical School
Assistant Investigator, Department of Psychiatry, Mass General Brigham