Prior to joining the Psychiatric and Neurodevelopmental Genetics Unit (PNGU) of the Center for Human Genetic Research (CHGR) in January 2005, Dr. Purcell completed his Ph.D. with Professor Pak Sham at King's College London, UK, followed by a 2-year visiting postdoc with Dr. Mark Daly at the Whitehead Institute for Biomedical Research, MIT.
Dr. Purcell's work is focused on developing statistical and computational tools for the design of genetic studies, the detection of gene variants influencing complex human traits and the dissection of these effects in the larger context of other genetic and environmental factors.
Dr. Purcell's specific methodological projects include: developing methods for the analysis of large scale association studies; studying gene-gene interaction (epistasis) and gene-environment interaction; detecting population stratification using genetic marker information; developing software for haplotype analysis; developing online resources for power calculation and simple genetic association analyses. Dr. Purcell collaborates with a number of clinical investigators both within the CHGR and internationally, working on a range of neuropsychiatric diseases including schizophrenia and bipolar disorder.
Information on these and other projects can be found at Dr. Purcell's main web page.
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