Dr. Smoller is Associate
Professor of Psychiatry at Harvard Medical
School and Associate Professor in the Department
of Epidemiology at the Harvard School of
Public Health. He is Assistant Vice Chair
of the MGH Department of Psychiatry where
he is also Director of the Psychiatric Genetics
Program in Mood and Anxiety Disorders. Dr.
Smoller is a founding member of the MGH
Mood and Anxiety Disorders Institute and
co-Director of the Genetics and Genomics
Unit of the MGH Clinical Research Program.
He received his undergraduate degree from
Harvard College, and MD from Harvard Medical
School. After completing his clinical training
in psychiatry at McLean Hospital, he earned
a doctoral degree in Epidemiology from the
Harvard School of Public Health and trained
as a postdoctoral fellow in the NIMH Training
Program in Psychiatric Genetics.
The focus of Dr. Smoller's research program
has been the identification of genetic determinants
of mood and anxiety disorders, including
bipolar disorder, major depression, panic
and phobic anxiety disorders as well as
schizophrenia and attention deficit hyperactivity
disorder (ADHD). Dr. Smoller and colleagues
have had a strong interest in phenotype
definition and have been investigating the
genetic relationships among mood disorders,
anxiety disorders and schizophrenia. A related
series of studies have focused on the genetic
basis of temperament profiles that may be
intermediate phenotypes for anxiety disorders,
mood disorders and ADHD. Dr. Smoller and
colleagues are also examining pharmacogenetic
predictors of response to antidepressant
and antianxiety medications. Research approaches
encompass genomewide and candidate gene
studies of psychiatric disorders and treatment
response phenotypes as well as studies examining
the genetic basis of neuroimaging measures
of brain function. Dr. Smoller and colleagues
have also been studying how advances in
genetics may impact clinical practice in
psychiatry.
|
