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Schnabel R, Larson MG, Dupuis J, Lunetta KL,
Lipinska I, Meigs JB, Yin X, Rong J, Vita JA,
Newton-Cheh C, Levy D, Keaney JF Jr, Vasan RS,
Mitchell GF, Benjamin EJ. Relations of inflammatory
biomarkers and common genetic variants with arterial
stiffness and wave reflection.
Hypertension. 2008 Jun;51(6):1651-7. Epub 2008
Apr 21.
Ji W, Foo JN, O'Roak BJ, Zhao H, Larson MG, Simon
DB, Newton-Cheh C, State MW, Levy D, Lifton RP.
Rare independent mutations in renal salt handling
genes contribute to blood pressure variation.
Nat Genet. 2008 May;40(5):592-9. Epub 2008 Apr
6.
Kathiresan S, Melander O, Anevski D, Guiducci
C, Burtt NP, Roos C, Hirschhorn JN, Berglund G,
Hedblad B, Groop L, Altshuler DM, Newton-Cheh
C, Orho-Melander M. Polymorphisms associated with
cholesterol and risk of cardiovascular events.
N Engl J Med. 2008 Mar 20;358(12):1240-9.
Lehtinen AB, Newton-Cheh C, Ziegler JT, Langefeld
CD, Freedman BI, Daniel KR, Herrington DM, Bowden
DW. Association of NOS1AP genetic variants with
QT interval duration in families from the Diabetes
Heart Study. Diabetes. 2008 Apr;57(4):1108-14.
Epub 2008 Jan 30.
Kathiresan S, Melander O, Guiducci C, Surti A,
Burtt NP, Rieder MJ, Cooper GM, Roos C, Voight
BF, Havulinna AS, Wahlstrand B, Hedner T, Corella
D, Tai ES, Ordovas JM, Berglund G, Vartiainen
E, Jousilahti P, Hedblad B, Taskinen MR, Newton-Cheh
C, Salomaa V, Peltonen L, Groop L, Altshuler DM,
Orho-Melander M. Six new loci associated with
blood low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol or triglycerides in humans.
Nat Genet. 2008 Feb;40(2):189-97. Epub 2008 Jan
13.
Vasan RS, Larson MG, Aragam J, Wang TJ, Mitchell
GF, Kathiresan S, Newton-Cheh C, Vita JA, Keyes
MJ, O'Donnell CJ, Levy D, Benjamin EJ.
Genome-wide association of echocardiographic dimensions,
brachial artery endothelial function and treadmill
exercise responses in the Framingham Heart Study.
BMC Med Genet. 2007 Sep 19;8 Suppl 1:S2.
Newton-Cheh C, Guo CY, Wang TJ, O'donnell CJ,
Levy D, Larson MG. Genome-wide association study
of electrocardiographic and heart rate variability
traits: the Framingham Heart Study. BMC Med Genet.
2007 Sep 19;8 Suppl 1:S7.
Larson MG, Atwood LD, Benjamin EJ, Cupples LA,
D'Agostino RB Sr, Fox CS, Govindaraju DR, Guo
CY, Heard-Costa NL, Hwang SJ, Murabito JM, Newton-Cheh
C, O'Donnell CJ, Seshadri S, Vasan RS, Wang TJ,
Wolf PA, Levy D. Framingham Heart Study 100K project:
genome-wide associations for cardiovascular disease
outcomes.
BMC Med Genet. 2007 Sep 19;8 Suppl 1:S5.
Levy D, Larson MG, Benjamin EJ, Newton-Cheh C,
Wang TJ, Hwang SJ, Vasan RS, Mitchell GF. Framingham
Heart Study 100K Project: genome-wide associations
for blood pressure and arterial stiffness.
BMC Med Genet. 2007 Sep 19;8 Suppl 1:S3.
Cupples LA, Arruda HT, Benjamin EJ, D'Agostino
RB Sr, Demissie S, DeStefano AL, Dupuis J, Falls
KM, Fox CS, Gottlieb DJ, Govindaraju DR, Guo CY,
Heard-Costa NL, Hwang SJ, Kathiresan S, Kiel DP,
Laramie JM, Larson MG, Levy D, Liu CY, Lunetta
KL, Mailman MD, Manning AK, Meigs JB, Murabito
JM, Newton-Cheh C, O'Connor GT, O'Donnell CJ,
Pandey M, Seshadri S, Vasan RS, Wang ZY, Wilk
JB, Wolf PA, Yang Q, Atwood LD.
The Framingham Heart Study 100K SNP genome-wide
association study resource: overview of 17 phenotype
working group reports.
BMC Med Genet. 2007;8 Suppl 1:S1.
Parikh NI, Gona P, Larson MG, Wang TJ, Newton-Cheh
C, Levy D, Benjamin EJ, Kannel WB, Vasan RS. Plasma
renin and risk of cardiovascular disease and mortality:
the Framingham Heart Study. Eur Heart J. 2007
Nov;28(21):2644-52. Epub 2007 Sep 25.
Newton-Cheh C, Guo CY, Larson MG, Musone SL,
Surti A, Camargo AL, Drake JA, Benjamin EJ, Levy
D, D'Agostino RB Sr, Hirschhorn JN, O'donnell
CJ.
Common genetic variation in KCNH2 is associated
with QT interval duration: the Framingham Heart
Study. Circulation. 2007 Sep 4;116(10):1128-36.
Epub 2007 Aug 20. Erratum in: Circulation. 2008
Jan 1/8;117(1):e9.
Aarnoudse AJ, Newton-Cheh C, de Bakker PI, Straus
SM, Kors JA, Hofman A, Uitterlinden AG, Witteman
JC, Stricker BH. Common NOS1AP variants are associated
with a prolonged QTc interval in the Rotterdam
Study.
Circulation. 2007 Jul 3;116(1):10-6. Epub 2007
Jun 18.
Ingelsson E, Larson MG, Vasan RS, O'Donnell CJ,
Yin X, Hirschhorn JN,
Newton-Cheh C, Drake JA, Musone SL, Heard-Costa
NL, Benjamin EJ, Levy D, Atwood LD, Wang TJ, Kathiresan
S. Heritability, linkage, and genetic associations
of exercise treadmill test responses. Circulation.
2007 Jun 12;115(23):2917-24. Epub 2007 Jun 4.
Newton-Cheh C, Shah R. Genetic determinants of
QT interval variation and sudden cardiac death.
Curr Opin Genet Dev. 2007 Jun;17(3):213-21. Epub
2007 Apr 30. Review.
Diabetes Genetics Initiative of Broad Institute
of Harvard and MIT, Lund University, and Novartis
Institutes of BioMedical Research, Saxena R, Voight
BF, Lyssenko V, Burtt NP, de Bakker PI, Chen H,
Roix JJ, Kathiresan S, Hirschhorn JN, Daly MJ,
Hughes TE, Groop L, Altshuler D, Almgren P, Florez
JC, Meyer J, Ardlie K, Bengtsson Boström
K, Isomaa B, Lettre G, Lindblad U, Lyon HN, Melander
O, Newton-Cheh C, Nilsson P, Orho-Melander M,
Råstam L, Speliotes EK, Taskinen MR, Tuomi
T, Guiducci C, Berglund A, Carlson J, Gianniny
L, Hackett R, Hall L, Holmkvist J, Laurila E,
Sjögren M, Sterner M, Surti A, Svensson M,
Svensson M, Tewhey R, Blumenstiel B, Parkin M,
Defelice M, Barry R, Brodeur W, Camarata J, Chia
N, Fava M, Gibbons J, Handsaker B, Healy C, Nguyen
K, Gates C, Sougnez C, Gage D, Nizzari M, Gabriel
SB, Chirn GW, Ma Q, Parikh H, Richardson D, Ricke
D, Purcell S. Genome-wide association analysis
identifies loci for type 2 diabetes and triglyceride
levels. Science. 2007 Jun 1;316(5829):1331-6.
Epub 2007 Apr 26.
Mitchell GF, Guo CY, Kathiresan S, Vasan RS,
Larson MG, Vita JA, Keyes MJ, Vyas M, Newton-Cheh
C, Musone SL, Camargo AL, Drake JA, Levy D, O'Donnell
CJ, Hirschhorn JN, Benjamin EJ. Vascular stiffness
and genetic variation at the endothelial nitric
oxide synthase locus: the Framingham Heart study.
Hypertension. 2007 Jun;49(6):1285-90. Epub 2007
Apr 2.
Newton-Cheh C, Guo CY, Gona P, Larson MG, Benjamin
EJ, Wang TJ, Kathiresan S, O'Donnell CJ, Musone
SL, Camargo AL, Drake JA, Levy D, Hirschhorn JN,
Vasan RS. Clinical and genetic correlates of aldosterone-to-renin
ratio and relations to blood pressure in a community
sample. Hypertension. 2007 Apr;49(4):846-56. Epub
2007 Feb 12.
Wang TJ, Gona P, Larson MG, Levy D, Benjamin
EJ, Tofler GH, Jacques PF, Meigs JB, Rifai N,
Selhub J, Robins SJ, Newton-Cheh C, Vasan RS.
Multiple biomarkers and the risk of incident hypertension.
Hypertension. 2007 Mar;49(3):432-8. Epub 2007
Jan 22.
Wang TJ, Gona P, Larson MG, Tofler GH, Levy D,
Newton-Cheh C, Jacques PF, Rifai N, Selhub J,
Robins SJ, Benjamin EJ, D'Agostino RB, Vasan RS.
Multiple biomarkers for the prediction of first
major cardiovascular events and death. N Engl
J Med. 2006 Dec 21;355(25):2631-9.
Arking DE, Pfeufer A, Post W, Kao WH, Newton-Cheh
C, Ikeda M, West K, Kashuk C, Akyol M, Perz S,
Jalilzadeh S, Illig T, Gieger C, Guo CY, Larson
MG, Wichmann HE, Marbán E, O'Donnell CJ,
Hirschhorn JN, Kääb S, Spooner PM, Meitinger
T,Chakravarti A. A common genetic variant in the
NOS1 regulator NOS1AP modulates cardiac repolarization.
Nat Genet. 2006 Jun;38(6):644-51. Epub 2006 Apr
30.
Kathiresan S, Larson MG, Vasan RS, Guo CY, Gona
P, Keaney JF Jr, Wilson PW, Newton-Cheh C, Musone
SL, Camargo AL, Drake JA, Levy D, O'Donnell CJ,
Hirschhorn JN, Benjamin EJ. Contribution of clinical
correlates and 13 C-reactive protein gene polymorphisms
to interindividual variability in serum C-reactive
protein level. Circulation. 2006 Mar 21;113(11):1415-23.
Epub 2006 Mar 13.
Kathiresan S, Gona P, Larson MG, Vita JA, Mitchell
GF, Tofler GH, Levy D, Newton-Cheh C, Wang TJ,
Benjamin EJ, Vasan RS. Cross-sectional relations
of multiple biomarkers from distinct biological
pathways to brachial artery endothelial function.
Circulation. 2006 Feb 21;113(7):938-45. Epub 2006
Feb 13. Erratum in: Circulation. 2006 Apr 4;113(13):e680.
Drake JA, Bird C, Nemesh J, Thomas DJ, Newton-Cheh
C, Reymond A, Excoffier L, Attar H, Antonarakis
SE, Dermitzakis ET, Hirschhorn JN. Conserved noncoding
sequences are selectively constrained and not
mutation cold spots. Nat Genet. 2006 Feb;38(2):223-7.
Epub 2005 Dec 25.
Kathiresan S, Larson MG, Vasan RS, Guo CY, Vita
JA, Mitchell GF, Keyes MJ, Newton-Cheh C, Musone
SL, Lochner AL, Drake JA, Levy D, O'Donnell CJ,
Hirschhorn JN, Benjamin EJ. Common genetic variation
at the endothelial nitric oxide synthase locus
and relations to brachial artery vasodilator function
in the community. Circulation. 2005 Sep 6;112(10):1419-27.
Epub 2005 Aug 29.
Newton-Cheh C, Larson MG, Corey DC, Benjamin
EJ, Herbert AG, Levy D,
D'Agostino RB, O'Donnell CJ. QT interval is a
heritable quantitative trait with evidence of
linkage to chromosome 3 in a genome-wide linkage
analysis: The Framingham Heart Study. Heart Rhythm.
2005 Mar;2(3):277-84.
Newton-Cheh C, Hirschhorn JN. Genetic association
studies of complex traits: design and analysis
issues. Mutat Res. 2005 Jun 3;573(1-2):54-69.
Review.
Kathiresan S, Newton-Cheh C, Gerszten RE. On
the interpretation of genetic association studies.
Eur Heart J. 2004 Aug;25(16):1378-81. No abstract
available.
Newton-Cheh C, O'Donnell CJ. Sex differences
and genetic associations with myocardial infarction.
JAMA. 2004 Jun 23;291(24):3008-10. No abstract
available.
Newton-Cheh C, Larson M, Kathiresan S, O'Donnell
C. On the significance of linkage studies of complex
traits. Am J Hum Genet. 2004 Jul;75(1):151-2;
author reply 152-4. No abstract available.
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