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Anxiety
Disorders and Anxious Temperament
Smoller JW, Paulus MP, Fagerness
JA, Purcell S, Yamaki LH, Hirshfeld-Becker D,
Biederman J, Rosenbaum JF, Gelernter J, and Stein
MB. Influence of RGS2 on anxiety-related temperament,
personality, and brain function. Arch Gen Psychiatry.
2008;65(3):298-308.
Smoller JW, Mark H. Pollack
MH, Wassertheil-Smoller S, Jackson RD, Oberman
A, Wong ND, Sheps D. Panic attacks and risk of
incident cardiovascular events among post-menopausal
women in the Women’s Health Initiative Observational
Study. Archives of General Psychiatry Arch Gen
Psychiatry. 2007;64(10):1153-1160.
Stewart SE, Platko J, Fagerness J, Birns J, Jenike
E, Smoller JW, Perlis R, Leboyer
M, Delorme R, Chabane N, Rauch SL, Jenike MA,
Pauls DL. A genetic family-based association study
of OLIG2 in obsessive-compulsive disorder. Arch
Gen Psychiatry 2007;64:209-215.
Smoller JW, Yamaki LH, Fagerness
JA, Biederman J, Racette S, Laird NM, Kagan J,
Snidman N, Faraone SV, Hirshfeld-Becker D, Tsuang
MT, Slaugenhaupt SA, Rosenbaum JF, and Sklar P.
The corticotropin releasing hormone gene and behavioral
inhibition in children at risk for panic disorder.
Biological Psychiatry 2005;57:1485-1492.
Koenen KC, Saxe G, Purcell S, Smoller
JW , Bartholomew D, Miller A, Hall E,
Kaplow J, Bosquet M, Moulton S, and Baldwin C.
Polymorphisms in FKBP5 are associated
with peri-traumatic dissociation in medically
injured children. Mol Psychiatry, 2005 Dec;10(12):1058-9
Smoller JW, Rosenbaum JF, Biederman
J, Kennedy J, Dai D, Racette S, Laird N, Kagan
J, Snidman NC, Hirshfeld-Becker, D, Tsuang MT,
Sklar PB, and Slaugenhaupt SA. Association of
a genetic marker at the corticotropin releasing
hormone locus with behavioral inhibition. Biological
Psychiatry 2003;54:1376-1381
Smoller JW, Pollack MH, Wassertheil-Smoller
S, Barton B, Hendrix SL, Jackson RD, Dicken T,
Oberman A, and Sheps DS. Prevalence and correlates
of panic attacks in post-menopausal women: Results
from an ancillary study to the Women’s Health
Initiative. Archives of Internal Medicine 2003;163:2041-2050.
Smoller JW, Acierno JS, Rosenbaum
JF, Biederman J, Pollack MH, Meminger S, Pava
J, Helbling L, White C, Bulzacchelli M, and Slaugenhaupt
SA. Targeted genome screen of panic disorder and
anxiety disorder proneness using homology to murine
QTL regions. American Journal of Medical Genetics
(Neuropsychiatric Genetics) 2001;105:195-206.
Smoller JW, Rosenbaum JF, Biederman
J, Susswein LS, Kennedy J, Kagan J, Snidman NC,
Laird N, Tsuang MT, Faraone SV, Schwarz A, and
Slaugenhaupt, SA. Genetic association analysis
of behavioral inhibition using candidate loci
from mouse models. American Journal of Medical
Genetics (Neuropsychiatric Genetics) 2001;105:226-235.
Smoller JW and Tsuang MT. Panic
and phobic anxiety: defining phenotypes for genetic
studies. American Journal of Psychiatry, 1998;
1152-1162.
Bipolar
Disorder and Depression
Sklar P, Smoller JW, Fan J,
Ferreira MA, Perlis RH, Chambert K, Nimgaonkar
VL, McQueen MB, Faraone SV, Kirby A, de Bakker
PIW, Ogdie MN, Thase ME, Sachs GS, Todd-Brown
K, Gabriel SB, Sougnez C, Gates C, Blumensteil
B, Defelice M, Ardlie KG, Franklin J, Muir WJ,
McGhee KA, MacIntyre DM, McLean A, VanBeck M,
McQullin A, Bass NJ, Robinson M, Lawrence J, Anjorin
A, Curtis D, Scolnick EM, Daly MJ, Blackwood DH,
Gurling HM, Purcell SM. Whole-genome association
study of bipolar disorder. Molecular Psychiatry
2008 Mar 4; [Epub ahead of print].
Perlis RH, Holt D, Smoller JW,
Blood A, Lee S, Kim BW, Lee MJ, Sun M, Makris
M, Kennedy D, Rooney K, Dougherty D, Hoge R, Rosenbaum
JF, Fava M, Gusella JF, Gasic G, and Breiter HC.
A polymorphism near CREB1 is associated with differential
aversion processing in the insula of healthy subjects.
Arch Gen Psychiatry, in press.
Perlis RH, Purcell S, Fagerness J, Cusin C, Yamaki
L, Fava M, and Smoller JW. Clinical
and genetic dissection of anger expression and
CREB1 polymorphisms in major depressive disorder.
Biol Psychiatry. 2007 Sep 1;62(5):536-40.
Simon NM, Smoller JW, McNamara
KL, Maser RS, Zalta AK, Pollack MH, Nierenberg
AA, Fava M, Wong KK. Telomere shortening and mood
disorders: preliminary support for a chronic stress
model of accelerated aging. Biol Psychiatry. 2006
Sep 1;60(5):432-5.
McQueen MB*, Devlin B*, Faraone SV*, Nimgaonkar
VL*, Sklar P*, Smoller JW*, Abou
Jamra R, Albus M, Bacanu S-A, Baron M, Barrett
TB, Berretini W, Blacker D, Byerley W, Cichon
S, Coryell W, Craddock N, Daly M, DePaulo JR,
Edenberg HJ, Foroud T, Gill M, Gilliam TC, Hamshere
M, Jones I, Jones L, Jou S-H, Kelsoe JR, Lambert
D, Lange C, Lerer B, Liu J, Maier W, MacKinnon
JD, McInnis MG, McMahon FJ, Murphy DL, Nothen
MM, Nurnberger JI, Pato CN, Pato MT, Potash JR,
Propping P, Pulver AE, Rice JP, Rietschel M, Scheftner
W, Schumacher J, Segurado R, Van Steen K, Xie
W, Zandi P, and Laird NM*. Combined analysis from
eleven linkage studies of bipolar disorder provides
strong evidence for susceptibility loci on chromosomes
6q and 8q. Am J Hum Genet, 2005 Aug 15;77:582-595.
*Principal members of the Meta-Analysis Working
Group for the Genetic Determinants of Bipolar
Disorder
Smoller JW and Finn CT. Family,
twin and adoption studies of bipolar disorder.
American Journal of Medical Genetics (Semin Med
Genet), 2003;123C:48-58.
Attention
Deficit Hyperactivity Disorder
Kim JW, Waldman ID, Faraone SV, Biederman J,
Doyle AE, Purcell S, Arbeitman L, Fagerness J,
Sklar P, and Smoller JW. Investigation
of parent-of-origin effects in ADHD candidate
genes. Am J Med Genet B Neuropsychiatr Genet.
2007 Sep 5;144(6):776-80.
Smoller JW, Biederman J, Arbeitman
L, Doyle AE, Fagerness J, Perlis RH, Sklar P,
Faraone, SV. Association between the 5HT1B receptor
gene and the inattentive subtype of ADHD. Biological
Psychiatry, 2006 Mar 1;59(5):460-7.
Faraone SV, Perlis RH, Doyle AE, Smoller
JW, Goralnick JJ, Holmgren MA and Sklar
PB. Molecular genetics of attention deficit hyperactivity
disorder. Biological Psychiatry 2005:57:1313-1323.
Genetic
Epidemiology and Methods
Vansteelandt S, DeMeo DL, Su J, Smoller
JW, Murphy AJ, McQueen M, Schneiter K,
Celedon JC, Weiss ST, Silverman EK, and Lange
C. Testing and estimating gene-environment interactions
in family-based association studies. Biometrics.
2007 Oct 26; [Epub ahead of print]
Freedman ML, Reich D, Penney KL, McDonald GJ,
Mignault AA, Patterson N, Gabriel SB, Topol EJ,
Smoller JW, Pato CN, Pato MT,
Petryshen TL, Kolonel LN, Lander ES, Sklar P,
Henderson B, Hirschhorn JN, and Altshuler D. Assessing
the impact of population stratification on genetic
association studies. Nature Genetics 2004;36:388-393.
Robins JM, Smoller JW, and Lunetta
KL. On the validity of the TDT test in the presence
of comorbidity and ascertainment bias. Genetic
Epidemiology 2001;21:326-336.
Smoller JW, Lunetta KL, Robins
J. Implications of comorbidity and ascertainment
bias for identifying disease genes. American Journal
of Medical Genetics (Neuropsychiatric Genetics)
2000;96:817-822.
Wilcox MA, Smoller JW, Lunetta
KL, Neuberg D. Using recursive partitioning for
exploration and follow-up of linkage and association
analyses. In: Goldin L et al.. Genetic Analysis
Workshop 11: Analysis of genetic and environmental
factors in common diseases. Genetic Epidemiology
17(suppl 1);1999:385-390.
Pharmacogenetics
Perlis RH, Purcell S, Fagerness J, Trivedi MH,
Fava M, Rush AJ, Smoller JW.
Pharmacogenetic analysis of genes implicated in
rodent models of antidepressant response: Association
of TREK1 and treatment resistance in the STAR*D
study. Neuropsychopharmacology. 2008 Feb 20; [Epub
ahead of print]
Perlis RH, Purcell S, Fava M, Fagerness J, Rush
AJ, Trivedi MH, and Smoller JW.
Association between treatment-emergent suicidal
ideation with citalopram and polymorphisms near
cAMP Response Element Binding Protein (CREB1)
in the STAR*D study. Arch Gen Psychiatry 2007;64:689-697.
Clinical
Applications
Smoller JW, Rosen-Sheidley B,
and Tsuang MT (eds). Psychiatric Genetics: Applications
in Clinical Practice. Washington, DC: American
Psychiatric Publishing, Inc., 2008.
Finn CT and Smoller JW. Genetic
counseling in psychiatry. Harv Rev Psychiatry.
2006 Mar-Apr;14(2):109-21.
Finn CT, Wilcox MA, Korf BR, Blacker DL, Racette
SA, Sklar P, Smoller JW . Psychiatric
genetics: a survey of psychiatrists’ knowledge,
opinions and practice patterns. J Clin Psychiatry
2005;66:821-830.
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