Photo of Wayne G. Shreffler, MD, PhD

Shreffler, Wayne G., MD, PhD

  • Chief, Pediatric Allergy & Immunology
  • Director, Food Allergy Center
  • Principal Investigator, Center for Immunology and Inflammatory Diseases

617-726-8707

Accepting New Patients

Enroll in my clinical trial

Overview

The mission of the food allergy center is to provide the best possible care through multidisciplinary care and research.

Departments

Pediatrics

Centers & Specialties

MassGeneral Hospital for Children

Clinical Interests
  • Food allergy
  • Eosinophilic gastrointestinal disease
  • Eczema (atopic dermatitis)
  • Asthma
  • Immunotherapy
Medical Education
  • MD, PhD, New York University School of Medicine
  • Residency, Montefiore Hospital & Medical Center
  • Fellowship, Mount Sinai Hospital Medical Center
Locations
  • Boston: Massachusetts General Hospital
Patient Gateway
Yes, learn more
Insurances Accepted
  • Aetna Health Inc.
  • Beech Street
  • Blue Cross Blue Shield - Blue Care 65
  • Blue Cross Blue Shield - Indemnity
  • Blue Cross Blue Shield - Managed Care
  • Blue Cross Blue Shield - Partners Plus
  • Cigna (PAL #'s)
  • Fallon Community HealthCare
  • Great-West Healthcare (formally One Health Plan)
  • Harvard Pilgrim Health Plan - ACD
  • Harvard Pilgrim Health Plan - PBO
  • Health Care Value Management (HCVM)
  • Humana/Choice Care PPO
  • MassHealth
  • Medicare
  • Medicare - ACD
  • Neighborhood Health Plan - ACD
  • Neighborhood Health Plan - PBO
  • OSW - Connecticut
  • OSW - Maine
  • OSW - New Hampshire
  • OSW - Rhode Island
  • Private Health Care Systems (PHCS)
  • Senior Whole Health
  • TriCare
  • Tufts Health Plan
  • Unicare
  • United Healthcare (non-HMO) - ACD
  • United Healthcare (non-HMO) - PBO

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.

Patient Age Group
Pediatric
Gender
Male

Edit Profile

Biography

Dr. Shreffler has developed a highly integrated research and clinical program to better understand the pathogenic mechanisms of food allergy and asthma and provide the best current and future care. The Shreffler laboratory focuses on the characterization of cellular and humoral immune response to dietary antigens and the mechanisms of allergen-induced Th2 sensitization and oral tolerance. Areas of active investigation include 1) the mechanisms of allergenic dendritic cell (DC) activation by allergens and the DC signals that induce Th2 differentiation; 2) the role of regulatory T cells in natural and immunotherapy-induced oral tolerance; 3) the role of IgE diversity and basophil activation and their regulation in both the effector response and in adaptive immune deviation in the context of food allergy and asthma.

Dr. Shreffler received his MD and PhD degrees from New York University and his Pediatrics training at the Albert Einstein College of Medicine. He completed his fellowship in Allergy & Immunology at the Mount Sinai School of Medicine in 2003. He is board certified in Pediatrics and Allergy/ Immunology and is a fellow of the American Academy of Allergy, Asthma and Immunology. He sits on the editorial board for the Journal of Allergy and Clinical Immunology, the leading specialty journal for his field.

Edit Profile

Research & Publications

Research Summary

The Shreffler laboratory focuses on the characterization of cellular and humoral immune response to dietary antigens and the mechanisms of allergen-induced Th2 sensitization and oral tolerance. Areas of active investigation include 1) the mechanisms of allergenic dendritic cell (DC) activation by allergens and the DC signals that induce Th2 differentiation; 2) the role of regulatory T cells in natural and immunotherapy-induced oral tolerance; 3) the role of IgE diversity and basophil activation and their regulation in both the effector response and in adaptive immune deviation in the context of food allergy and asthma. We primarily work with human samples, often in conjunction with clinical interventional or observational studies, to interrogate both the innate and adaptive immune responses to major dietary and aeroallergens.

Working together with numerous collaborators including from the Consortium for Food Allergy Research , the Inner City Asthma Consortium and our own newly established Food Allergy Center at MGH, we are adapting the use of polychromatic flow cytometry, peptide microarray-based humoral immune profiling and systems biology approaches to uniquely characterize the phenotype and function of allergen-specific T and B cell responses and the regulations of effector cells in pediatric food allergy and asthma.

Also important is the effort to understand why some food proteins are potent allergens. In other words, what are the mechanisms that influence early immune fate decisions to allergens and the intrinsic properties of those allergens that facilitate an allergic response. We are studying this in human and murine model systems.

Publications

View my most recent publications at PubMed

see PubMed link.

Edit Profile

News & Events

  • Introducing Your Infant to Allergens: Understanding the Latest Recommendations

    Wayne Shreffler, MD, PhD, the chief of Pediatric Allergy and Immunology and director of the Food Allergy Center at Massachusetts General Hospital, provides insight into new National Institute of Allergy and Infectious Disease recommendations and their potential implications for patient care.

  • Thirteen tips to Navigate the Holidays Joyfully and Safely

    Shift the focus from holiday foods and plan memorable holiday activities for your children to enjoy this season that are safe and free from allergens.

  • MGHfC physicians engage with ‘mommy bloggers’

    Nine local mothers who blog about parenthood visited MassGeneral Hospital for Children (MGHfC) on July 31 to meet MGHfC physicians and learn about three popular pediatric health topics – obesity, food allergy and sleep behavioral disorders.

  • What are the differences between oral immunotherapy and food challenges?

    Wayne Shreffler, MD, PhD, division chief of Pediatric Allergy & Immunology at MassGeneral Hospital for Children and director of the Food Allergy Center at Massachusetts General Hospital, explains the differences between food challenges, which are established methods of care, and oral immunotherapy, which is still in research.

  • Diagnosing and Treating Food Allergy in Pediatric Patients

    Food allergy is an immune-based disease affecting an estimated 5 percent of children younger than age 5 and 4 percent of teens and adults.

  • Peanut Oral Immunotherapy Study at the Food Allergy Center

    The Food Allergy Center is currently enrolling peanut allergic children ages 7–21 years in an oral immunotherapy (OIT) study, which involves administering small doses of peanut powder, increased over time. Read about Deb Edmunds’ insiders experience with her daughter, Ashley Edmunds, who is currently enrolled.

  • Food Allergies and School: Frequently Asked Questions

    The Food Allergy team at MassGeneral Hospital for Children answers common concerns about food allergies and school.

  • Are Kids at Risk When Peanuts Are Served on Airplanes?

    Wayne Shreffler, MD, PhD, a pediatric allergist at MassGeneral Hospital for Children and director of the Food Allergy Center at Massachusetts General Hospital, answers questions about proposed changes to air travel regulations.

  • Are Babies Taking Longer to Outgrow Milk Allergies?

    Research presented at the annual meeting of the American Academy of Allergy, Asthma & Immunology indicates that children may not outgrow milk allergies as early in life as experts had thought.

  • Food Allergy Center patient testimonials

    Read about three patients who have benefited from services at the Food Allergy Center.

  • The Food Allergy Center at Massachusetts General Hospital and MassGeneral Hospital for Children

    With the hope of making a long-term impact in the field, The Food Allergy Center at Massachusetts General Hospital (MGH) and MassGeneral Hospital for Children (MGHfC) has been established to diagnose and treat known and suspected cases of food allergies.

  • Are Food Allergies Over-Diagnosed?

    Wayne Shreffler, MD, PhD, a pediatric allergist at MassGeneral Hospital for Children and director of the Food Allergy Center at Massachusetts General Hospital, answers questions about the diagnosis and treatment of food allergies.

  • Establishment of the Mass General Food Allergy Center

    In Fall 2009, Massachusetts General Hospital established a comprehensive center for the treatment and study of food allergy and food-related disorders to provide state-of-the-art care while investigating the mysteries that underlie these inadequately understood and as yet incurable diseases.

  • Food Allergy Management Boot Camp

    On Monday, August 21 at 3pm, the MassGeneral Hospital for Children Food Allergy Center welcomes parents and caregivers to an interactive group session that will teach best practices in protecting and promoting your child's unique health needs. Lead by Michael Pistiner, MD, MMSc, director of Food Allergy Advocacy, Education and Prevention at MGHfC, this discussion will help: • Gain mastery of food allergy management skills • Increase confidence in avoiding food allergens • Ease day-to-day stress of living with food allergy • Coach others and your children on living confidently and safely To attend this immersive event in MGH's Haber Auditorium in Blake 1, please RSVP to foodallergy@mgh.harvard.edu. If you aren't able to attend the Food Allergy Management Boot Camp, follow along with the conversation on MGHfC's Twitter account using hash tag #FoodAllergyBootCamp.

  • Food Allergy Management Boot Camp

    On Monday, August 21 at 3pm, the Mass General Hospital for Children Food Allergy Center welcomes parents and caregivers to an interactive group session that will teach best practices in protecting and promoting your child's unique health needs. Lead by Michael Pistiner, MD, MMSc, director of Food Allergy Advocacy, Education and Prevention at MGHfC, this discussion will help: • Gain mastery of food allergy management skills • Increase confidence in avoiding food allergens • Ease day-to-day stress of living with food allergy • Coach others and your children on living confidently and safely To attend this immersive event in MGH's Haber Auditorium in Blake 1, please RSVP to foodallergy@mgh.harvard.edu. If you aren't able to attend the Food Allergy Management Boot Camp, follow along with the conversation on MGHfC's Twitter account using hash tag #FoodAllergyBootCamp.

Contact

Pediatric Allergy and Pulmonary Unit
275 Cambridge Street
MGH Professional Office Building
Boston, MA 02114-3108
Phone: 617-726-8707
Fax: 617-724-2803

Edit Profile

Back to Top