Photo of Josephine (Josephine) Mun-Yee Lok, MD

Josephine (Josephine) Mun-Yee Lok, MD

  • Physician, Assistant in Pediatrics, Pediatric Critical Care Medicine


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Centers & Specialties

MassGeneral Hospital for Children

Clinical Interests
  • Sepsis and Septic Shock
  • Brain injury
  • Critical care education
Medical Education
  • MD, Albert Einstein College of Medicine
  • Residency, Beth Israel Deaconess Medical Center|Residency, Tufts Medical Center
  • Fellowship, The Johns Hopkins Hospital
Board Certifications
  • Pediatric Critical Care Medicine
  • Boston: Massachusetts General Hospital
Insurances Accepted
  • Aetna Health Inc.
  • Beech Street
  • Blue Cross Blue Shield - Blue Care 65
  • Blue Cross Blue Shield - Indemnity
  • Blue Cross Blue Shield - Managed Care
  • Blue Cross Blue Shield - Partners Plus
  • Centene/Celticare
  • Cigna (PAL #'s)
  • Fallon Community HealthCare
  • Great-West Healthcare (formally One Health Plan)
  • Harvard Pilgrim Health Plan - ACD
  • Harvard Pilgrim Health Plan - PBO
  • Health Care Value Management (HCVM)
  • Humana/Choice Care PPO
  • MassHealth
  • Medicare
  • Medicare - ACD
  • Neighborhood Health Plan - ACD
  • Neighborhood Health Plan - PBO
  • OSW - Connecticut
  • OSW - Maine
  • OSW - New Hampshire
  • OSW - New York
  • OSW - Rhode Island
  • Private Health Care Systems (PHCS)
  • Senior Whole Health
  • TriCare
  • Tufts Health Plan
  • Unicare
  • United Healthcare (non-HMO) - ACD
  • United Healthcare (non-HMO) - PBO
Patient Age Group

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Research & Publications

Research Summary
My research focuses on the neurovascular responses, in particular as it relates to the pathological processes after brain trauma.  I am also interested in the actions of neuregulin-1, an endogenous growth factor, within the neurovascular unit.  NRG1 is known to be important in the function of neurons and glia, but its activity in endothelial cells is not as well defined.  My goals were to 1) determine whether NRG1 plays significant roles in the biology of brain microvascular endothelial cells; and 2) to investigate the neuroprotective potential of NRG1 in brain trauma.  Data from my experiments demonstrated that NRG1 has key functions in brain microvascular cells; in particular, NRG1 prevents endothelial hyper-permeability due to cytokine injury, a significant finding given the many pathological processes that stem from microvascular hyper-permeability during CNS and systemic illness. 

View my most recent publications at PubMed

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News & Events

  • Research of Josephine Lok, MD

    The microvascular endothelium is instrumental in many processes in the brain, including oxygen delivery, barrier function, and response to inflammation. After brain trauma, microvasculature disturbances lead to increased permeability, vasoconstriction, and capillary occlusion, events which amplify the primary insult. An understanding of these endothelial responses to injury is important in the investigation of neuroprotective strategies during brain injury. This topic forms one major area of my research.


Pediatric Critical Care Unit
55 Fruit Street
Boston MA, 02114-2696
Phone: 617-724-4380
Fax: 617-724-4391

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