Dr. Fasano sees pediatric and adult patients at the Center for Celiac Research and Treatment.
World-renowned pediatric gastroenterologist, research scientist and entreprenuer Dr. Alessio Fasano is chief of Pediatric Gastroenterology and Nutrition at MassGeneral Hospital for Children (MGHfC). Dr. Fasano directs the Center for Celiac Research, specializing in the treatment of patients of all ages with gluten-related disorders, including celiac disease, wheat allergy and gluten sensitivity. He treats patients with acute and chronic diarrheal diseases, and treats infants and children who have difficult-to-treat gastrointestinal problems.
Dr. Fasano also directs the Mucosal Immunology and Biology Research Center and is associate chief for Basic, Clinical and Translational Research. Under his leadership, investigators are studying the molecular mechanisms of autoimmune disorders including celiac disease, and other-gluten-related disorders. He has been named visiting professor of pediatrics at Harvard Medical School. He authored the groundbreaking study in 2003 that established the rate of celiac disease at one in 133 Americans. Widely sought after by national and international media, Dr. Fasano has been featured in hundreds of interviews including outlets such as The New York Times, The Wall Street Journal; National Public Radio; CNN; Bloomberg News, and others.
Dr. Fasano is director of the Mucosal Immunology and Biology Research Center at MassGeneral Hospital for Children. Dr. Fasano's research established that celiac disease affects approximately 1 percent of the U.S. population, a significantly higher number than previously believed, and helped define gluten sensitivity as a condition on the spectrum of gluten-related disorders. His research also uncovered the role that impairment of the tight junctions between intestinal enterocytes plays in the development of celiac disease.
During research designed to develop a cholera vaccine, Dr. Fasano uncovered a toxin, zonula occludens, which causes diarrhea by loosening the tight junctions and allowing intestinal permeability. Subsequently, he identified the protein zonulin, which controls this process. He has since established the role of zonulin in the pathogenesis of a number of autoimmune diseases, including celiac disease, type 1 diabetes, and certain cancers and diseases of the nervous system.
Calling for action on the final steps before implementation of safe gluten-free labeling regulations, Dr. Alessio Fasano joined Rep. Nita Lowey (D-NY) in an Op-Ed published in the Huffington Post Healthy Living section on April 3.
Transcending the disciplines of microbiology, molecular and cell biology, and physiology, Dr. Alessio Fasano’s research focuses on the mucosal biology of the gut. By focusing on the “cross talk” between enteric pathogens and their hosts, Dr. Fasano’s group has elucidated various organs and cell functions involved in health and disease, including inflammatory and autoimmune disorders.
Dr. Alessio Fasano, director of the Center for Celiac Research at MassGeneral Hospital for Children, separates the myths from the realities about the gluten-free diet in this video with Huffington Post science editor Jacqueline Howard.
In a long-awaited step toward accurate gluten-free food labeling, the U.S. Food and Drug Administration (FDA) has released its definition of “gluten free” to be used by food manufacturers.
People with celiac disease and other gluten-related disorders soon will have something to celebrate with the recent launch of the Celiac Program at Harvard Medical School. Advancing basic and clinical research is the main goal of the partnership of experts in celiac care from Massachusetts General Hospital, Beth Israel Deaconess Medical Center and Boston Children’s Hospital, along with collaboration in clinical and training initiatives.
This course is designed to meet one or more of the following Accreditation Council of Graduate Medical Education competencies: Patient care; Medical knowledge; Practice-based learning and improvement; Interpersonal and communication skills; Professionalism; Systems-based practice
The FDA has released its definition of "gluten free" to be used by food manufacturers. The long-awaited regulations stem from research conducted by the Center for Celiac Research.
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