Photo of Alessio  Fasano, MD

Alessio Fasano, MD

  • W. Allan Walker Chair in Pediatric Gastroenterology and Nutrition
  • Division Chief, Pediatric Gastroenterology and Nutrition; Director, Center for Celiac Research and Treatment
  • Director, Mucosal Immunology and Biology Research Center; Associate Chief for Basic, Clinical and Translational Research


Accepting New Patients

Visit my website Enroll in my clinical trial


Dr. Fasano sees pediatric and adult patients at the Center for Celiac Research and Treatment.



Centers & Specialties

MassGeneral Hospital for Children

Clinical Interests
  • Celiac disease
  • Gluten-related disorders
  • Non-celiac gluten sensitivity
  • Dermatitis herpetiformis
  • Wheat allergy
  • Gluten ataxia
Medical Education
  • MD, University of Naples School of Medicine
  • Residency, University of Naples School of Medicine
Foreign Languages
  • French
  • Italian
  • Boston: Massachusetts General Hospital
Insurances Accepted
  • Aetna Health Inc.
  • Beech Street
  • Blue Cross Blue Shield - Blue Care 65
  • Blue Cross Blue Shield - Indemnity
  • Blue Cross Blue Shield - Managed Care
  • Blue Cross Blue Shield - Partners Plus
  • Cigna (PAL #'s)
  • Fallon Community HealthCare
  • Great-West Healthcare (formally One Health Plan)
  • Harvard Pilgrim Health Plan - ACD
  • Harvard Pilgrim Health Plan - PBO
  • Health Care Value Management (HCVM)
  • Humana/Choice Care PPO
  • MassHealth
  • Medicare
  • Medicare - ACD
  • Neighborhood Health Plan - ACD
  • Neighborhood Health Plan - PBO
  • OSW - Maine
  • OSW - New Hampshire
  • OSW - Rhode Island
  • Private Health Care Systems (PHCS)
  • Senior Whole Health
  • TriCare
  • Tufts Health Plan
  • Unicare
  • United Healthcare (non-HMO) - ACD
  • United Healthcare (non-HMO) - PBO

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.

Patient Age Group
Adult and Pediatric

Edit Profile


World-renowned pediatric gastroenterologist, research scientist and entreprenuer Dr. Alessio Fasano is chief of Pediatric Gastroenterology and Nutrition at MassGeneral Hospital for Children (MGHfC). Dr. Fasano directs the Center for Celiac Research, specializing in the treatment of patients of all ages with gluten-related disorders, including celiac disease, wheat allergy and gluten sensitivity. He treats patients with acute and chronic diarrheal diseases, and treats infants and children who have difficult-to-treat gastrointestinal problems.

Dr. Fasano also directs the Mucosal Immunology and Biology Research Center and is associate chief for Basic, Clinical and Translational Research. Under his leadership, investigators are studying the molecular mechanisms of autoimmune disorders including celiac disease, and other-gluten-related disorders. He has been named visiting professor of pediatrics at Harvard Medical School. He authored the groundbreaking study in 2003 that established the rate of celiac disease at one in 133 Americans. Widely sought after by national and international media, Dr. Fasano has been featured in hundreds of interviews including outlets such as The New York Times, The Wall Street Journal; National Public Radio; CNN; Bloomberg News, and others.

Edit Profile

Research & Publications

Research Summary

Dr. Fasano is director of the Mucosal Immunology and Biology Research Center at MassGeneral Hospital for Children. Dr. Fasano's research established that celiac disease affects approximately 1 percent of the U.S. population, a significantly higher number than previously believed, and helped define gluten sensitivity as a condition on the spectrum of gluten-related disorders. His research also uncovered the role that impairment of the tight junctions between intestinal enterocytes plays in the development of celiac disease.

During research designed to develop a cholera vaccine, Dr. Fasano uncovered a toxin, zonula occludens, which causes diarrhea by loosening the tight junctions and allowing intestinal permeability. Subsequently, he identified the protein zonulin, which controls this process. He has since established the role of zonulin in the pathogenesis of a number of autoimmune diseases, including celiac disease, type 1 diabetes, and certain cancers and diseases of the nervous system.


View my most recent publications at PubMed

Edit Profile

News & Events


Pediatric Gastroenterology and Nutrition
55 Fruit Street
Boston MA, 02114-2696
Phone: 617-726-8705
Fax: 617-724-2710

Edit Profile

Back to Top