Research Day

Presented by the MassGeneral Hospital for Children Research Council annually in the spring, Research Day highlights recent accomplishments and advances from Mass General researchers, as well as from the broader pediatric research community.

Research Day 2014

The Sixth Annual MassGeneral Hospital for Children Research Day was held on March 18th, 2014.

Keynote Lectures:

“An Overview of Autism Spectrum Disorder” by Christopher J. McDougle, MD, Nancy Lurie Marks Professor of Psychiatry, Director, Lurie Center of Autism

AND

“Is Autism an Autoimmune Disease” by Alessio Fasano, MD, Chief, Division of Pediatric Gastroenterology and Nutrition, Associate Chief, Department of Pediatrics Basic, Clinical and Translational Research, Director, Center for Celiac Research, Director, Mucosal Immunology and Biology Research Center, MassGeneral Hospital for Children, Visiting Professor, Harvard Medical School

MGHfC Faculty Lectures

“Cross-talk between the host and enteric pathogens: what do they talk about and what can go wrong when they do not understand each other”
Maria Rosaria Fiorentino, PhD
Lecturer in Pediatrics

“The Influence of Nutritional Exposures on the Preterm Infant Intestinal Microbiome”
Katherine Gregory, PhD
Clinical Instructor in Pediatrics

“Optimizing health and survival of HIV-exposed children in Botswana through research”
Kathleen Powis, MD, MPH
Instructor in Pediatrics

Poster Session Awardees

  • Lauren Kleimola (Mentor: Patricia Hibberd, MD, PhD). Stunted growth in early childhood is associated with exposure to household air pollution.
  • Nanda Kumar N. Shanmugam, Post-Doctoral Fellow (Mentor: Bobby Cherayil, MD, PhD). Intestinal inflammation modulates expression of the iron regulating hormone hepcidin depending on erythropoietin activity and the commensal microbiota
  • Vibha Singhal, MD (Mentor: Madhu Misra, MD, MPH). Irisin levels are lower in young amenorrheic athletes compared with eumenorrheic athletes and non-athletes and correlate with bone structure and strength estimates

Research Day 2013

Keynote Lecture: “Molecular Dissection of the new disorder Eosinophilic Esophagitis”
Stephanie Seminara, MD, Co-Director of the Reproductive Endocrine Associates, Massachusetts General Hospital, and Associate Professor of Medicine, Harvard Medical School

MGHfC Faculty Lectures

“Assessing the Safety and Efficacy of Inhaled Nitric Oxide in Cerebral Malaria”
Ryan Carroll, MD, Assistant in Pediatrics, MassGeneral Hospital for Children, Instructor in Pediatrics, Harvard Medical School

“The Preterm Infant's Behavioral Pain Response”
Kim Francis PhD, RN, PHCNS-BC, Neonatal Clinical Nurse Specialist for the Massachusetts General Hospital Obstetric Service, Clinical Instructor for the MGH Institute of Health Professions, Haley Nurse Fellow for Boston College and Brigham & Women’s Hospital

“Effects of Growth Hormone Augmentation on Visceral Fat and Metabolic Risk in HIV-infection”
Takara Stanley, MD, Assistant in Pediatrics, MassGeneral Hospital for Children, Assistant Professor in Pediatrics, Harvard Medical School

Poster Session Awardees

  • Mridu Acharya (Mentor: Adam Lacy-Hulbert, PhD). αv integrins use autophagy machinery to modulate specific B cell immune responses
  • Peter P. Moschovis, MD, MPH (Mentor: Patricia Hibberd, MD, PhD). Household air pollution and risk of childhood pneumonia death in low and middle income countries
  • Deepak Palakshappa MD. Communication discrepancies between Pediatric Residents and Attendings; a supervision dilemma for residency training programs

Research Day 2012

Keynote Lecture: “Molecular Dissection of the new disorder Eosinophilic Esophagitis”
Marc Rothenberg, MD, PhD
Director of Allergy and Immunology at Cincinnati Children's Hospital Medical Center and the Cincinnati Center for Eosinophilic Disorders

MGHfC Faculty Lectures

“Immune Therapy in Type 1 Diabetes”
Nicole Sherry, MD
Instructor in Pediatrics, Harvard Medical School
Director, Diabetes Program, Pediatric Endocrinology, MassGeneral Hospital for Children

“Modulation of Mucosal Immunity by Intestinal Helminth Infection”
Haining Shi, DVM, PhD
Assistant Professor of Pediatrics, Harvard Medical School
Mucosal Immunology Laboratory, MassGeneral Hospital for Children

“Use of the Built Environment to Promote Physical Activity in Children”
Nicolas Oreskovic, MD, MPH
Instructor in Pediatrics, Harvard Medical School
Internal Medicine & Pediatrics, Massachusetts General Hospital
Center for Child & Adolescent Health Research and Policy

“Human RAG deficiency: not just immunodeficiency--Novel insights into mechanisms of immune dysregulation”
Jolan Walter, MD, PhD
Clinical Instructor in Pediatrics, Harvard Medical School
Physician, Pediatric Allergy/Immunology, MassGeneral Hospital for Children

Poster Session Awardees

  • Elena Grant: Childhood Repair of Tetralogy of Fallot Leads to Long Term Hepatic Dysfunction
  • Selvi Ramasamy: The TLE1 Tumor Suppressor Regulates Myc Induced Leukemogenesis
  • Ana Sokovska/Christine Becker (co-first author presenters): Rab39a Links Caspase-1 Activation to Phagosome Acidification and Cellular Defense

Research Day 2011

Keynote Lecture: “Stem and Progenitor Cells in Neonatal Lung Injury and Repair”
Dr. Vivek Balasubramaniam
Univ. of Colorado – Director of Pediatric Heart Lung Center

MGHfC Faculty Lectures

Elahna Paul, MD, PhD
Instructor in Pediatrics, Harvard Medical School
Pediatric Nephrology, MassGeneral Hospital for Children

Jonathan Spector, MD
Instructor in Pediatrics, Harvard Medical School
Neonatology and Newborn Medicine, MassGeneral Hospital for Children

Ann-Christine Duhaime, MD
Nicholas T. Zervas Professor of Neurosurgery
Pediatric Neurosurgery, MassGeneral Hospital for Children

Poster Session Awardees

  • Mauro Longoni. Diaphragmatic hernia: genetic dissection of a complex birth defect. Laboratory of Patricia K. Donahoe
  • Jay Thiagarajah. Airway surfactant liquid depth imaged by surface laser reflectance microscopy. Laboratories of Jay Thiagarajah and A.S. Verkman.
  • Orane Visvikis. Involvement of HLH-30/MiT transcription factors in intestinal epithelial immunity. Laboratory of Javier E. Irazoqui

Research Day 2010

Keynote Lecture: “Update on Obesity Research”
Lee Kaplan, MD, PhD
Director, MGH Weight Center

MGHfC Faculty Lectures

“Immunity to Cholera”
Jason Harris, MD
Assistant Professor of Pediatrics, Harvard Medical School
Pediatric Infectious Disease Division, MassGeneral Hospital for Children

“Primary Care Management of Chronic Conditions in Pediatrics”
Jeanne Van Cleave, MD
Instructor of Pediatrics, Harvard Medical School
Academic General Pediatrics Program, MassGeneral Hospital for Children

“Innate Immunity – Learning on the Fly”
Lynda Stuart, MD
Assistant Professor of Pediatrics, Harvard Medical School
Developmental Immunology Program at MassGeneral Hospital for Children

Poster session awardees:

  • Leah Jacoby - Total and site-specific fat and lean mass as predictors of bone density in female adolescent athletes – working with Dr. Madhu Misra in Pediatric Endocrinology at MassGeneral Hospital for Children
  • Patricia Rodriguez Bachiller - TGF-ß decreases expression of NO signaling enzymes in the injured newborn lung and in vascular smooth muscle cells -working with Jesse Roberts in the Pediatric ICU at MassGeneral Hospital for Children
  • Helena Paidassi - Description of novel innate activation of macrophage: Role in host immunity and intestinal immunopathology - work with Adam Lacy-Hulbert in Development Immunology at MassGeneral Hospital for Children

Research Day 2009

Keynote Lecture: “Genomics and the study of Clinical Diseases”
David Altshuler, MD, PhD
Professor of Genetics and Professor of Medicine, Harvard Medical School
Director, Broad Institute, Program in Medical and Population Genetics

MGHfC Faculty Lectures

“Skeletal Effects of Anorexia Nervosa in Adolescents”
Madhu Misra, MD, MPH
Assistant Professor of Pediatrics, Harvard Medical School
Pediatric Endocrinology, MassGeneral Hospital for Children

“Ironing out the wrinkles in host defense: interactions between innate immunity and iron homeostatis”
Bobby Cherayil, MD
Associate Professor of Pediatrics, Harvard Medical School
Mucosal Immunology Laboratory, Massachusetts General Hospital

“Making a brain in the gut: molecular development of the enteric nervous system”
Allan Goldstein, MD
Associate Professor of Surgery, Harvard Medical School
Pediatric Surgery, MassGeneral Hospital for Children

Poster Session Awardees

  • Volodymyr Dzhala (Kevin Staley's lab) - Chloride accumulation and phenobarbital failure in neonatal seizures.
  • Marshall Karpel (Emmet Schmidt's lab) - A novel L-ficolin-mannose binding lectin chimeric molecule with enhanced activity against lethal viral infections.
  • Jianfeng Wang (David Sweetser's lab) - Groucho/TLE corepressors regulate myeloid differentiation and size of the stem cell/progenitor population

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Recognizing pediatric research

Pediatric researchers were celebrated at the sixth annual MassGeneral Hospital for Children Research Day in the Simches Building.

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What will we discover next?

Learn how researchers at MassGeneral Hospital for Children are finding new treatments that advance pediatric care.