Research Centers

Pediatric Endocrine-Neuroendocrine-Sports Endocrine Research

Research within the Pediatric Sports Endocrine Lab aims to further medical knowledge about the common endocrine issues facing athletes today. In particular, we focus our efforts on establishing findings that lead to the adaptation and improvement of medical care for female athletes.

Sports Endocrine Research

The female athlete triad is the interrelationship of amenorrhea, low energy availability, and decreased bone mineral density. Many young female athletes are afflicted with some aspect of this condition. It has been determined that up to 69% of women participating in sports such as running experience menstrual dysfunction, as compared to only 2-5% of the general population. A major concern associated with the female athlete triad is low bone mineral density. Decreased bone mineral density has been reported in 22-50% of female athletes as compared to 12% of the normal population. Decreased bone mineral density during adolescence puts these athletes at higher fracture risk. Therefore, it is imperative to address this serious and widespread issue.

Photo of VO2 endurance test

Bionutritionist Tara Holmes obtaining readings during the VO2 endurance test.

Our research group has made significant progress in investigating this condition within a population of teenage girls and young adult women. In an effort to adapt the treatment model for this disorder, we hope to further elucidate the factors that lead to menstrual dysfunction in some but not all athletes. We are also exploring associations of components of the triad with bone structure and strength, hormone levels, body composition, and other clinical variables.

Current research studies are aimed at further investigating:

  • the effect of a replacement dose of estrogen and progesterone on bone mineral density
  • a possible difference in efficacy of transdermal versus oral estrogen on bone mineral density
  • cross-sectional differences among amenorrheic athletes, eumenorrheic athletes, and non-athletes related to:
    • energy availability
    • VO2 endurance testing
    • cognitive ability
    • fracture risk and prevention
    • genetic predispositions
    • body composition

Anorexia Nervosa

Our group has demonstrated that low bone density is prevalent in adolescent girls and boys with anorexia nervosa and is associated with decreased bone turnover. Hormonal alterations that predict low bone density in this disorder include hypogonadism, a nutritionally acquired resistance to growth hormone effects, and high cortisol levels. Weight gain and resumption of menses are associated with some improvement in bone parameters, however, residual deficits persist, raising concerns regarding inadequate catch-up and suboptimal peak bone mass acquisition. Studies exploring possible therapeutic strategies to improve bone density in teenagers with anorexia nervosa are ongoing.

Obesity

Our group has demonstrated that growth hormone and cortisol status are important determinants of visceral fat and cardiometabolic risk in teenagers with obesity. We are currently evaluating the effect of low dose growth hormone administration on body composition and cardiometabolic risk in obese adolescent girls.

Neuroendocrine
Anne Klibanski, MD Anne Klibanski, MD
Laurie Carrol Guthart Professor of Medicine, Harvard Medical School
Chief, Neuroendocrine Unit, Massachusetts General Hospital
Phone: 617 726 3870       Fax: 617 726 5072
Pediatric Endocrine
Madhusmita (Madhu) Misra, MD, MPH Madhusmita (Madhu) Misra, MD, MPH
Professor of Pediatrics, Harvard Medical School
Program Director, Pediatric Endocrinology, MassGeneral Hospital for Children
Co-Chair, MGHfC Research Council
Associate Director, HCCRC, Harvard Catalyst
Pediatrician, MassGeneral Hospital for Children
Phone: 617 726 3870       Fax: 617 726 8528        E-mail: mmisra@partners.org
Sports Medicine and Endocrinology
Kathryn Ackerman, MD, MPH Kathryn Ackerman, MD, MPH
Instructor in Medicine, Harvard Medical School
Assistant in Medicine, Massachusetts General Hospital
Phone: 617-726-7528     Fax: 617 726 8528        E-mail: keackerman@partners.org
Clinical Research Fellow
Vibha Singhal, MD
Phone: 617-726-1428     Fax: 617-726-8528
Nurse Practitioner
Meghan Slattery, NPMeghan Slattery, NP
Phone: 617-643-0267   Fax: 617 726 8528        E-mail: mslattery@partners.org

Study Coordinators and Assistants

Hannah Clarke, BS
Phone: 617-724-6046   Fax: 617 726 8528        E-mail: hclarke@partners.org

Katherine Wargo, BA
Phone: 617-643-6739   Fax: 617 726 8528

Amelia Mostovoy, BA
Phone: 617-643-0266   Fax: 617-726-8528

Female Athlete Study

We have an on-going clinical trial involving the study of female adolescent athletes, ages 14-25, who are not getting their periods compared to athletes who are getting their periods and non-athletes. Athletes who are not getting their periods will receive either a low-dose transdermal estrogen patch along with oral progesterone, a low dose estrogen and progesterone pill, or no hormonal treatment. One aim of this study is to determine changes in body composition and hormones that differentiate those receiving transdermal therapy, oral therapy, or no therapy. Another aim of the study is to determine whether transdermal or oral estrogen (versus no estrogen) is effective in increasing bone density and improving bone microarchitecture in adolescent athletes who are not getting their periods and are thus estrogen deficient.

Frequently Asked Questions

1. Will scheduling be a problem since I’m a full-time student and a division one athlete?

We understand that most participants are in high school or college and have very busy schedules. We respect your time commitments and work hard to plan visits around your schedules so that participants do not have to miss their classes, jobs, or team commitments. For example, some visits can take place on your campus and we often see participants at MGH on weekends.

2. I will be out of town for the summer months. Will that be an issue for scheduling my visits?

Not at all! Visits occur at 3 month intervals so we can coordinate a visit before you leave for the summer and then again when you return in the fall. If you let us know ahead of time when you’ll be away, we can work out the dates so they fit best with your schedule.

3. Is it safe for me to participate?

All the components of this study have been approved by a human safety board called the Institutional Review Board to ensure that the protocol and all the procedures we do are safe for participants.

4. How much radiation do I get from all the imaging during the study?

The total radiation from participation in our study for 1 year is only 3% of the average person’s annual exposure. To put it in perspective, the total radiation a person is exposed to on a one-way flight from New York to Seattle is 0.14 millisieverts (mSV) and from New York to London is 0.236 mSV but girls in our study are only exposed to 0.074 mSV over the course of the entire year.

5. What is a DXA scan?

A DXA scan is a non-invasive test for measurement of bone mineral density (BMD), and measures “central” or “axial” skeletal sites (spine), “peripheral” sites (hip), as well as fat and muscle mass.  In conventional DXA systems, 2 energies of x-rays are used to calculate a 2-D measurement of bone density.  For this test, participants will need to remove all metal items (jewelry, underwire bras, etc.) and will be required to change into hospital pants and gown and lie still on a table for just a few minutes while the whole body is scanned by the DXA machine. This test usually costs up to $500, but since it is a part of the study, all participants get to keep their results from the scan for free.

6. What is the METCART assessment/indirect calorimetry test?

A metabolic cart assessment, sometimes referred to as indirect calorimetry, is used to estimate the number of calories burned by the body in a resting state.  After an 8- to 12-hour fast (no food or beverages except water), the participant is instructed to lie down and a clear plastic hood or “canopy” is placed over her head.  For the next 20 minutes, she simply lies still and breathes normally while the machine collects and analyzes her breath, providing an estimate of her metabolic rate. This test provides information for both athletes and non-athletes about their metabolism, and by being a part of the study, all participants get to keep the results from this assessment.

7. What is the purpose of the CT scan?

The CT scan is an imaging study that helps us visualize the structure of bones at a microscopic level. This gives us a more detailed picture of bone than a DXA does, and may better predict fracture risk. The CT scan will help us determine how bone structure is affected by hormonal changes in female athletes.

8. How does the treadmill exercise test work?

The treadmill test is a way for us to determine your endurance level. During this test, participants are hooked up to:

(i) EKG leads (small stickers are placed on the chest and wires connected to the EKG machine are attached to these stickers to allow us to examine the heart’s activity)

(ii) a blood pressure cuff, and

(iii) a facemask that measures VO2 (from oxygen consumption and carbon dioxide produced) while they run on the treadmill.

The treadmill gradually increases in speed and incline until the participant signals that she is ready to stop, or when heart rate, blood pressure, EKG or VO2 measurements indicate that the test is complete or should be stopped. The results help us determine the metabolic rate and endurance capacity of all participants in the study for comparison. And again, as a participant, you get to keep these results. We suggest that subjects come dressed in comfortable gym clothes for this component of the study.

9. How do I get paid for my participation?

Participants are compensated for every visit except the screening visit. Participants will be mailed a check shortly after completion of any specific visit.

10. I received a bill for a study visit in the mail. Should I pay it?

From time to time, participants are sent bills by mistake. Participants should not pay for anything related to a study visit. If you receive a bill, either mail it or bring it in to your next visit and a study coordinator will take care of it.

11. Will my doctor receive the results from the study?

That is up to you. If you would like us to mail results from your visits to your primary care doctor we can do so. However, you will need to sign a release of information form in order for us to send your information to your doctor/s. No information will be relayed to your doctor unless you want it to be.

Bibliography

Research Investigations

  1. Corey KE, Stanley TL, Misdraji J, Scirica C, Pratt J, Hoppin A, Misra M. Prevalence and Outcome of Nonalcoholic Fatty Liver Disease in Adolescents and Young Adults Undergoing Weight Loss Surgery. Pediatr Obes 2014. In Press.
  2. Fazeli PK, Wang IS, Miller KK, Herzog DB, Misra M, Lee H, Finkelstein JS, Bouxsein ML, Klibanski A. Teriparatide increases bone formation and bone mineral density in adult women with anorexia nervosa. J Clin Endocrinol Metab 2014. In Press
  3. Faje AT, Fazeli PK, Miller KK, Katzman DK, Ebrahimi S, Lee H, Mendes N, Snelgrove D, Meenaghan E, Misra M, Klibanski A. Fracture Risk and Areal Bone Mineral Density in Adolescent Females with Anorexia Nervosa. Int J Eating Disord 2014. In Press.
  4. Slattery M, Bredella M, Misra M. Insulin Resistance and Impaired Mitochondrial Function in Obese Adolescent Girls. Metab Syndr Relat Disord. In Press.
  5. Phan CM, Khalilzadeh O, Dinkel J, Wang I, Bredella MA, Misra M, Miller KK, Klibanski A, Gupta R. C-arm CT for histomorphometric evaluation of lumbar spine trabecular microarchitecture: a study in Anorexia Nervosa patients. Br J Radiol 2013; 86(1027):20120451.
  6. Misra M. Katzman DK, Clarke H, Snelgrove D, Brigham K, Miller KK, Klibanski A. Hip Structural Analysis in Adolescent boys with Anorexia Nervosa and Normal-Weight Controls. J Clin Endocrinol Metab 2013; 98(7):2952-8. PMCID:PMC3701273
  7. Misra M, Katzman DK, Estella NM, Eddy K, Miller KK, Klibanski A. Impact of Estrogen Replacement Therapy on Anxiety Symptoms, Body Shape Perception and Eating Attitudes in Adolescent Girls with Anorexia Nervosa. J Clin Psychiatr 2013;74(8):e765-71.
  8. Faje A, Karim L, Taylor A, Lee H, Miller KK, Mendes N, Meenaghan E, Bouxsein ML, Misra M, Klibanski A Adolescent Girls with Anorexia Nervosa have Impaired Cortical and Trabecular Microarchitecture and Lower Estimated Bone Strength at the Distal Radius. J Clin Endocrinol Metab 2013;98(5):1923-9. PMCID: PMC3644600.
  9. Ackerman KE, Pierce L, Guereca G, Slattery M, Lee H, Goldstein M, Misra M. Hip Structural Analysis in Adolescent and Young Adult Oligo-amenorrheic and Eumenorrheic Athletes and Non-athletes. J Clin Endocrinol Metab 2013; 98(4):1742-9 PMCID: PMC3615200.
  10. Faje A,  Fazeli PK, Katzman D, Miller KK, Breggia A, Rosen CJ, Mendes N, Misra M, Klibanski A. Inhibition of Pref-1 by Estradiol in Adolescent Girls with Anorexia Nervosa is Associated with Improvement in  Lumbar Bone Mineral Density. Clin Endocrinol (Oxf). 2013;79(3):326-32. PMCID:PMC364065
  11. Fazeli PK, Ackerman KE, Pierce L, Guereca G, Bouxsein M, Misra M. Sclerostin and Pref-1 have Differential Effects on Bone Mineral Density and Strength Parameters in Adolescent Athletes Compared with Non-athletes. Osteoporos Int 2013; 24(9):2433-40. PMCID:PMC3740025
  12. McManus S, Levitsky LL, Misra M. Adolescents with Polycystic Ovary Syndrome: Normal-Weight and Overweight Phenotypes. Endocr Pract. 2013;19(3):471-478. PMID: 23816935.
  13. Lawson EA, Ackerman KE, Estella NM, Guereca G, Pierce L, Sluss PM, Bouxsein ML, Klibanski A, Misra M. Nocturnal Oxytocin Secretion is Lower in Amenorrheic Athletes than Non-Athletes and Associated with Bone Microarchitecture and Finite Element Analysis Parameters. European J Endocrinol 2013;168(3):457-64. PMCID:PMC3679669
  14. Sinha M, Stanley TL, Webb J, Scirica C, Corey K, Pratt J, Boepple PA, Hoppin A, Misra M. Metabolic Effects of Roux-en-Y Gastric Bypass in Obese Adolescents and Young Adults. J Pediatr Gastroenterol Nutr 2012;56(5):528-31.PMCID:PMC3637417
  15. Fazeli P, Mendes N, Russell M, Herzog DB, Klibanski A, Misra M. Bone Density Characteristics and Major Depressive Disorder in Adolescents. Psychosomatic Med 2013;75(2):117-23. PMCID: PMC3570708
  16. Neumeyer AM, Gates A, Ferrone C, Lee H, Misra M. The Effect of Autism on Bone Metabolism in Peripubertal Boys. J Autism Develop Disord 2013;43(7):1623-9. PMID:23124396.
  17. Stanley T, Bredella M, Mendes Estella N, Pierce L, Misra M.  The Ratio of Parathyroid Hormone to Vitamin D is a Determinant of Cardiovascular Risk and Insulin Sensitivity in Adolescent Girls. Metab Syndr Relat Disord. 2013;11(1):56-62. PMCID: PMC3593691
  18. Bredella M, McManus S, Misra M. Impact of Metformin Monotherapy versus Metformin with Oestrogen-Progesterone on Lipids in Adolescent Girls with Polycystic Ovarian Syndrome. Clin Endocrinol 2013: 79, 199–203.  PMID: 22928702
  19. Lawson EA*, Fazeli PK*, Calder G, Putnam H, Misra M, Meenaghan E, Miller KK, Klibanski A. Plasma Sodium Level is Associated with Bone Loss Severity in Women with Anorexia Nervosa. Journal of Clinical Psychiatry 2012;73(11):e1379-83. PMCID: PMC3729037
  20. Ackerman KE, Putman M, Guereca G, Taylor AP, Pierce L, Herzog DB, Klibanski A, Bouxsein M, Misra M. Cortical Microstructure and Estimated Bone Strength in Young Amenorrheic Athletes, Eumenorrheic Athletes and Non-Athletes. Bone 2012; 51(4):680-687. PMCID: PMC3482939.
  21. von Oettingen J, Sola Pou J, Levitsky LL, Misra M. Clinical Presentation of Premature Adrenarche. Clin Pediatr (Phila) 2012;51(12):1140-9. PMID: 22893187.
  22. Faje AT, Fazeli P, Katzman DK, Breggia A, Rosen CJ  Mendes N, Klibanski A, Misra M. Sclerostin Levels and Bone Turnover Markers in Adolescents with Anorexia Nervosa and Normal Adolescent Girls. Bone 2012; 51(3):474-9. PMCID: PMC3412913.
  23. Ackerman KE, Patel K, Guereca G, Pierce L, Herzog DB, Misra M. Cortisol Secretory Parameters in Young Exercisers in Relation to LH Secretion and Bone Parameters. Clin Endocrinol (Oxf) 2013;78(1):114-9. PMCID: PMC3443505.
  24. Ackerman KE, Slusarz K, Guereca G, Pierce L, Slattery M, Mendes N, Herzog DB, Misra M. Higher Ghrelin and Lower Leptin Secretion is Associated with Lower LH Secretion in Young Amenorrheic Athletes Compared with Eumenorrheic Athletes and Controls. Am J Physiol Endocrinol Metab 2012;302(7):E800-6. PMCID:PMC3330709
  25. Fazeli PK, Calder G, Miller KK, Misra M, Lawson EA, Meenaghan E, Lee H, Herzog DB, Klibanski A. Psychotropic Medication Use in Anorexia Nervosa between 1997 and 2009. Int J Eat Disord 2012;45(8):970-6. PMCID:PMC3726215
  26. Ackerman KE, Skrinar GS, Medvedova E, Misra M, Miller KK. Estradiol Levels Predict Bone Mineral Density in Male Collegiate Athletes. Clin Endocrinol (Oxf) 2012;76(3):339-45. PMCID: PMC3274603
  27. Lawson EA, Miller KK, Blum JI, Meenaghan E, Misra M, Eddy KT, Herzog DB, Klibanski A. Leptin Levels Are Associated With Decreased Depressive Symptoms in Women Across the Weight Spectrum, Independent of Body Fat. Clin Endocrinol. 2012;76(4):520-5. PMCID: PMC3296868
  28. Ackerman KE*, Nazem T*, Chapko C, Russell M, Mendes N, Taylor AP, Bouxsein ML, Misra M. Bone Microarchitecture is Impaired in Adolescent Amenorrheic Athletes Compared with Eumenorrheic Athletes and Non-Athletic Controls. J Clin Endocrinol Metab 2011;96(10):3123-33. PMCID: PMC3200253
  29. Puzhko S*, Goodyer CG*, Kerachian MA, Canaff L, Misra M, Jüppner H, Bastepe M, Hendy GN. Parathyroid hormone signaling via Gαs is selectively inhibited by an NH2- terminally truncated Gαs: implications for pseudohypoparathyroidism. J Bone Miner Res 2011;26(10):2473-85. PMID: 21713996.
  30. Ackerman KE, Davis B, Jacoby L, Misra M. DXA Surrogates for Visceral Fat are Inversely Associated with Bone Density Measures in Adolescent Athletes with Menstrual Dysfunction. J Pediatr Endocrinol Metab 2011;24(7-8):497-504. PMCID: PMC3652985
  31. Misra M, Katzman DK, Miller KK, Mendes N, Snelgrove D, Russell M, Goldstein MA, Ebrahimi S, Clauss L, Weigel T, Mickley D, Schoenfeld D, Herzog DB, Klibanski A. Physiologic Estrogen Replacement Increases Bone Density in Adolescent Girls with Anorexia Nervosa. J Bone Miner Res 2011;26(10):2430-8. PMCID: PMC3304439
  32. Russell M, Breggia A, Mendes N, Klibanski A, Misra M. Growth Hormone is Positively Associated with Surrogate Markers of Bone Turnover during Puberty. Clin Endocrinol 2011;75(4):482-8. PMCID: PMC3722873
  33. Miller KK, Meenaghan E, Lawson EA, Misra M, Gleysteen S, Schoenfeld D, Herzog D, Klibanski A. Effects of Risedronate and Low-Dose Transdermal Testosterone on Bone Mineral Density in Women with Anorexia Nervosa:  A Randomized, Placebo-Controlled Study. J Clin Endocrinol Metab 2011. 96(7):2081-8. PMCID: PMC3135194.
  34. Lawson EA, Donoho DA, Blum J, Meenaghan E, Misra M, Herzog DB, Sluss P, Miller KK, Klibanski A. Decreased Nocturnal Oxytocin Levels in Anorexia Nervosa Are Associated with Low Bone Mineral Density and Fat Mass. J Clin Psychiatr 2011;72(11):1546-51. PMCID:PMC3731046
  35. Balhara B, Misra M, Levitsky LL. Clinical Monitoring Guidelines for Congenital Hypothyroidism:  Laboratory Outcome Data in the First Year of Life. J Pediatr 2011; 158(4):532-7. PMID: 21094953
  36. Savgan-Gurol E, Bredella M, Russell M, Mendes N, Klibanski A, Misra M. Waist to hip ratio and trunk to extremity fat (DXA) are better surrogates for IMCL and for visceral fat respectively than for subcutaneous fat in adolescent girls. Nutr Metab (Lond) 2010;7(1):86. PMCID: PMC3018385.
  37. Lawson EA, Eddy K, Donoho D, Misra M, Miller KK, Meenaghan E, Lydecker J, Herzog D, Klibanski A. Appetite Regulating Hormones Cortisol and Peptide YY are Associated with Disordered Eating Psychopathology Independent of Body Mass Index. Eur J Endocrinol 2010;164(2):253-61. PMCID: PMC3677777.
  38. Fazeli PK, Lawson EA, Prabhakaran R, Miller KK, Donoho D, Clemmons DR, Herzog DB, Misra M, Klibanski A. Effects of Recombinant Human Growth Hormone in Anorexia Nervosa: A Randomized, Placebo-Controlled Study. J Clin Endocrinol Metab. 2010;95(11):4889-97. PMCID: PMC2968733
  39. Brick DJ, Gerweck AV, Meenaghan E, Lawson EA, Misra M, Fazeli P, Johnson W,  Klibanski A, Miller KK. Determinants of IGF-1 and GH Throughout the Weight Spectrum:  From Anorexia Nervosa to Obesity. Eur J Endocrinol 2010; 163(2):185-91. PMCID: PMC2953770
  40. Katavetin P, Cheunsuchon P, Grant E, Boepple PA, Hedley-Whyte ET, Misra M, Levitsky LL. Rathke’s Cleft Cysts in Children and Adolescents: Association with Female Puberty. J Pediatr Endocrinol Metab 2010:23(11);1175-80. PMID: 21284332
  41. Walsh CJ, Phan CM, Misra M, Bredella MA, Miller KK, Fazeli P, Bayraktar HH, Klibanski A, Gupta R. Finite Element and Trabecular Structure Analysis in Anorexia Nervosa via Flat-Panel Volume CT. Radiology 2010;257(1):167-74. PMCID: PMC2941723
  42. Misra M, Le Clair M, Mendes N, Miller KK, Lawson EA, Meenaghan E, Weigel T, Ebrahimi S, Herzog DB, Klibanski A. Use of SSRIs may Impact Bone Density in Adolescent and Young Women with Anorexia Nervosa. CNS Spectrums 2010; 15(9):579-586.
  43. Katavetin P, Cheunsuchon P, Swearingen B, Hedley-Whyte ET, Misra M, Levitsky LL Pituitary Adenomas in Children and Adolescents. J Pediatr Endocrinol Metab 2010;23(5): 427-32. PMID: 20662340
  44. Wong KN, Levitsky LL, Misra M. Predictors of Growth Consequences of Central Hypothyroidism in Pediatric Patients Receiving Recombinant Human Growth Hormone. J Pediatr Endocrinol Metab 2010;23(5): 451-62. PMID: 20662344
  45. Lloyd B, Ravi P, Mendes N, Klibanski A, Misra M. Peptide YY Levels across Pubertal Stages and Associations with Growth Hormone. J Clin Endocrinol Metab 2010; 95(6):2957-62. PMCID: PMC2902078
  46. Bredella MA, Ghomi RH, Thomas BJ, Torriani M, Brick DJ, Gerweck AV, Misra M, Klibanski A, Miller KK. Comparison of DXA and CT in the assessment of body composition in premenopausal women with obesity and anorexia nervosa. Obesity (Silver Spring). 2010 Nov;18(11):2227-33. PMCID: PMC3607308
  47. Russell M, Mendes N, Miller KK, Rosen CJ, Klibanski A, Misra M. Visceral Fat is a Negative Predictor of Bone Density Measures in Obese Adolescent Girls. J Clin Endocrinol Metab 2010; 95(3):1247-55. PMCID: PMC2841531
  48. Wojcik MH, Meenaghan E, Lawson EA, Misra M, Klibanski A, Miller KK. Reduced Amylin Levels Are Associated with Low Bone Mineral Density in Women with Anorexia Nervosa. Bone. 2010 Mar;46(3):796-800. PMCID: PMC2824019
  49. Fazeli PK, Misra M, Goldstein M, Miller KK, Klibanski A. FGF-21 May Mediate Growth Hormone Resistance in Anorexia Nervosa. J Clin Endocrinol Metab. 2010;95(1):369-74. PMCID: PMC2805486
  50. Fazeli PK, Bredella MA, Misra M, Meenaghan E, Rosen CJ, Breggia A, Miller KK, Klibanski A. Pref-1 Predicts Marrow Adiposity and Bone Mineral Density in Women with Anorexia Nervosa. Clin Endocrinol Metab. 2010;95(1):407-13. PMCID: PMC2805488
  51. Stanley T, Levitsky LL, Grinspoon S, Misra M. Effect of Body Mass Index on Peak Growth Hormone Response to Provocative Testing in Children with Short Stature. J Clin Endocrinol Metab 2009; 94(12):4875-81. PMCID: PMC2795667
  52. Lawson EA, Miller KK, Donoho D, Misra M, Meenaghan E, Lydecker J, Wexler T, Herzog D, Klibanski A. Hypercortisolemia predicts severity of bone loss, anxiety and depression in hypothalamic amenorrhea and anorexia nervosa. J Clin Endocrinol Metab 2009;94(12):4710-6. PMCID: PMC2795653
  53. Lawson EA, Miller KK, Bredella MA, Phan C, Misra M, Meenaghan E, Rosenblum L, Donoho D, Gupta R, Klibanski A. Hormone Predictors of Abnormal Bone Microarchitecture in Women with Anorexia Nervosa. Bone 2009; 6(2):458-63. PMCID: PMC2818221
  54. Misra M, McGrane J, Miller KK, Goldstein MA, Ebrahimi S, Weigel T, Klibanski A. Effects of rhIGF-1 Administration on Surrogate Markers of Bone Turnover in Adolescents with Anorexia Nervosa. Bone 2009; 45:493-8. PMCID: PMC3590307
  55. Russell M, Bredella M, Tsai P, Mendes N, Miller KK, Klibanski A, Misra M. Relative Growth Hormone Deficiency and Cortisol Excess are Associated with Increased Cardiovascular Risk Markers in Obese Adolescent Girls. J Clin Endocrinol Metab 2009; 94:2864-71. PMCID: PMC2730871
  56. Russell M, Stark J, Nayak S, Miller KK, Herzog DB, Klibanski A, Misra M Peptide YY in Adolescent Athletes with Amenorrhea, Eumenorrheic Athletes and Non-Athletic Controls. Bone 2009;45(1):104-9. PMCID: PMC2692763.
  57. Bredella M, Fazeli PK, Miller KK, Misra M, Torriani M, Thomas BJ, Ghomi RH, Rosen CJ, Klibanski A. Increased Bone Marrow Fat in Anorexia Nervosa. J Clin Endocrinol Metab 2009; 94(6):2129-36. PMCID: PMC2690416
  58. Misra M, Tsai P, Mendes N, Miller KK, Klibanski A. Increased Carbohydrate Induced Ghrelin Secretion in Obese versus Normal-weight Adolescent Girls. Obesity 2009;17(9):1689-95. PMCID: PMC3687036
  59. McCormack S, Mitchell DM, Woo M, Levitsky LL, Ross DS, Misra M. Radioactive Iodine for Hyperthyroidism in Children and Adolescents: Referral Rate and Response to Treatment. Clin Endocrinol 2009; 71(6): 884 – 891. PMID: 19250263
  60. Lawson EA, Misra M, Meenaghan E, Rosenblum L, Donoho DA, Herzog DB, Klibanski A, Miller KK. Adrenal glucocorticoid and androgen precursor dissociation in anorexia nervosa. J Clin Endocrinol Metab 2009; 94(4):1367-71. PMCID: PMC2682472
  61. Taylor C, Lamparello B, Kruczek, K, Anderson E, Hubbard J, Misra M. Validation of a Food Frequency Questionnaire for Calcium and Vitamin D Intake in Adolescent Girls with Anorexia Nervosa. J Amer Diet Assoc 2009;109(3); 497-485;e3. PMCID: PMC2673098.
  62. Misra M, Katzman DK, Cord J, Manning  SJ, Mickley D, Herzog DB, Miller KK, Klibanski A. Percent Extremity Fat, but not Percent Trunk Fat, is Lower in Adolescent Boys with Anorexia Nervosa Compared with Healthy Adolescents. Am J Clin Nutr 2008; 88(6):1478-84. PMCID:PMC3722579
  63. Misra M, Bredella M, Tsai P, Mendes N, Miller KK, Klibanski A. Lower Growth Hormone and Higher Cortisol are Associated with Greater Visceral Adiposity, Intramyocellular Lipids and Insulin Resistance in Overweight Girls. Am J Physiol Endocrinol Metab 2008;295(2):E385-92. PMCID: PMC2519763
  64. Misra M, Katzman DK, Cord J, Manning  SJ, Mendes N, Herzog DB, Miller KK, Klibanski A. Bone Metabolism in Adolescent Boys with Anorexia Nervosa and its Determinants. J Clin Endocrinol Metab 2008;93(8):3029-3036. PMCID: PMC2515086.
  65. Bredella MA, Misra M, Miller KK, Sarwar A, Madisch I, Cheung A, Klibanski A, Gupta R.  Distal Radius in Adolescent Girls with Anorexia Nervosa:Trabecular Structure Analysis with Very High Resolution Flat Panel Volume CT. Radiology. 2008;249(3):938-46. PMCID: PMC2691811
  66. Utz AL, Lawson EA, Misra M, Minihan JL, Lee EE, Mathur VA, Herzog DB, Klibanski A, Miller KK. Peptide YY (PYY) Levels and Bone Mineral Density (BMD) in Women with Anorexia Nervosa. Bone 2008;43(1):135-9. PMCID: PMC2493518.
  67. Christo K, Cord J, Mendes N, Miller KK, Goldstein M, Herzog DB, Klibanski A, Misra M. Acylated Ghrelin and Leptin in Adolescent Athletes with Amenorrhea, Eumenorrheic Athletes and Controls: A Cross-sectional Study. Clin Endocrinol 2008;69(4):628-33. PMCID:PMC3206259.
  68. Prabhakaran R*, Misra M*, Miller KK, K. Kruczek, S. Sundaralingam, Herzog DB, Debra K. Katzman, Klibanski A. Determinants of Height in Adolescent Girls with Anorexia Nervosa. Pediatrics 2008;121(6):e1517-e1523. PMID: 18519455.
  69. Misra M, Prabhakaran P, Miller KK, Tsai P, Goldstein M, Mickley D, Clauss L, Lockhart P, Herzog DB, Katzman D, Klibanski A. Prognostic Indicators of Changes in Bone Density in Adolescent Girls with Anorexia Nervosa and Healthy Adolescents-II. J Clin Endocrinol Metab 2008; 93(4):1292-7. PMCID: PMC2291487.
  70. Misra M, Prabhakaran P, Miller KK, Tsai P, Goldstein M, Mickley D, Clauss L, Lockhart P, Herzog DB, Katzman D, Klibanski A. Weight Gain and Restoration of Menses as Predictors of Bone Mineral Density Change in Adolescent Girls with Anorexia Nervosa-1. J Clin Endocrinol Metab 2008; 93(4):1231-7. PMCID: PMC2291495.  
  71. Christo K*, Prabhakaran R*, Lamparello B, Cord J, Miller KK, Goldstein M, Gupta N, Herzog DB, Klibanski A, Misra M. Bone Metabolism in Adolescent Amenorrheic and Eumenorrheic Athletes and Controls. Pediatrics 2008; 121(6):1127-1136. PMCID:PMC3208310
  72. Misra M, Cord J, Prabhakaran R, Miller KK, Klibanski A. Growth Hormone Suppression Following an Oral Glucose Load in Children. J Clin Endocrinol Metab 2007; 92(12):4623-9.
  73. Demura M, Martin RM, Shozu M, Sebastian S, Takayama K, Hsu W, Schultz RA, Neely K, Bryant M, Mendonca BB, Hanaki K, Kanzaki S, Rhoads DB, Misra M, Bulun SE. Regional Rearrangements in Chromosome 15q21 Cause Formation of Cryptic Promoters for the CYP19 (Aromatase) Gene. Hum Mol Genet 2007; 16(21):2529-41.
  74. Lawson EA, Miller KK, Mathur VA, Lee EE, Misra M, Grinspoon S, Herzog DB, Klibanski A. Hormonal and Nutritional Effects on Cardiovascular Risk Markers in Young Women. J Clin Endocrinol Metab 2007;92(8):3089-94.
  75. Miller KK, Wexler TL, Zha A, Lawson EA, Meenaghan E, Misra M, Binstock A, Herzog DB and Klibanski A. Androgen Deficiency:  Association with Increased Anxiety and Depression Symptom Severity in Anorexia Nervosa. J Clin Psychiatry 2007;68(6):959-965
  76. Misra M, Miller KK, Cord J, Prabhakaran R, Goldstein M, Katzman DK, Herzog DB, Klibanski A. Relationships between Serum Adipokines, Insulin Levels and Bone Density in Girls with Anorexia Nervosa. J Clin Endocrinol Metab 2007; 92(6):2046-52.
  77. Miller KK, Lawson LE, Mathur V, Wexler T, Meenaghan E, Misra M, Herzog DB, Klibanski A. Androgens in Women with Anorexia Nervosa and Normal-Weight Women with Hypothalamic Amenorrhea. J Clin Endocrinol Metab 2007;92(4):1334-9.
  78. Misra M, Miller KK, Tsai P, Stewart V, End A, Freed N, Herzog DB, Goldstein M, Riggs S, Klibanski A. Uncoupling of Cardiovascular Risk Markers in Adolescent Girls with Anorexia Nervosa. J Pediatr 2006;149 (6):763-9.
  79. Miller KK, Lee EE, Lawson E, Misra M, Minihan J, Grinspoon SK, Gleysteen S, Mickley D, Herzog DB, Klibanski A. Determinants of Skeletal Recovery in Anorexia Nervosa. J Clin Endocrinol Metab 2006;91(8):2931-7.
  80. Misra M, Tsai P, Anderson EJ, Hubbard J, Gallagher K, Soyka LA, Miller, KK, Herzog DB, Klibanski A. Nutrient Intake in Community Dwelling Adolescent Girls with Anorexia Nervosa and Healthy Adolescents. Am J Clin Nutr 2006;84:698-706.
  81. Misra M, Prabhakaran R, Miller KK, Tsai P, Lin A, Lee N, Herzog DB, Klibanski A. Role of Cortisol in Menstrual Recovery in Adolescent Girls with Anorexia Nervosa. Pediatr Res 2006:59; 598-603.
  82. Misra M, Miller KK, Tsai P, Gallagher K, Lin A, Noel L, Herzog DB, Klibanski A. Elevated Peptide YY Levels in Adolescent Girls with Anorexia Nervosa. J Clin Endocrinol Metab 2006;91:1027-33. Epub 2005 Nov 8.
  83. Misra M, Miller KK, Stewart V, Hunter E, Kuo K, Herzog DB, Klibanski A. Ghrelin and Bone Metabolism in Adolescent Girls with Anorexia Nervosa 2005 J Clin Endocrinol Metab 2005: 90: 5082-5087; Epub 2005 July 5.
  84. Misra M, Miller KK, Kuo K, Griffin K, Stewart V, Hunter E, Herzog DB, Klibanski A. Secretory Dynamics of Leptin in Adolescent Girls with Anorexia Nervosa and Healthy Adolescents 2005 Am J Physiol Endocrinol Metab 289(3):E373-81. Epub 2005 Apr 5.
  85. Misra M, Miller KK, Kuo K, Griffin K, Stewart V, Hunter E, Herzog DB, Klibanski A. Secretory Dynamics of Ghrelin in Adolescent Girls with Anorexia Nervosa and Healthy Adolescents 2005 Am J Physiol: Endocrinol Metab 289(2):E347-56. Epub 2005 Mar 8
  86. Misra M, Miller KK, Almazan C, Worley M, Herzog DB, Klibanski A. Hormonal Determinants of Regional Body Composition in Adolescent Girls with Anorexia Nervosa and Controls. J Clin Endocrinol Metab. 2005;90:2580-7. Epub 2005 Feb 15
  87. Misra M, Aggarwal A, Miller KK, Almazan C, Worley M, Soyka LA, Herzog D, Klibanski, A. Effects of Anorexia Nervosa on Clinical, Hematological, Biochemical and Bone Density Parameters in Community Dwelling Adolescent Girls. Pediatrics. 2004;114:1574-1583.
  88. Misra M, Miller KK, Almazan C, Ramaswamy K, Lapcharoensap W, Worley M, Neubauer G, Herzog DB, Klibanski A. Alterations in Cortisol Secretory Dynamics in Adolescent Girls with Anorexia Nervosa and Effects on Bone Metabolism. J Clin Endocrinol Metab. 2004;89:4972-80.
  89. Misra M, Miller KK, Almazan C, Ramaswamy K, Aggarwal A, Herzog DB, Neubauer G, Breu J, Klibanski A. Hormonal and Body Composition Predictors of Soluble Leptin Receptor, Leptin and Free Leptin Index in Adolescent Girls with Anorexia Nervosa and Controls and Relation to Insulin Sensitivity. J Clin Endocrinol Metab. 2004;89:3486-95.
  90. Misra M, Miller KK, Herzog DB, Ramaswamy K, Aggarwal A, Almazan C, Neubauer G, Breu J, Klibanski A. Growth Hormone and Ghrelin Responses to an Oral Glucose Load in Adolescent Girls with Anorexia Nervosa and Controls. J Clin Endocrinol Metab. 2004;89:1605-12.
  91. Misra M, Miller KK, Bjornson J, Hackman A, Aggarwal A, Chung J, Ott M, Herzog DB, Johnson ML, Klibanski A. Alterations in Growth Hormone Secretory Dynamics in Adolescent Girls with Anorexia Nervosa and Effects on Bone Metabolism. J Clin Endocrinol Metab. 2003;88:5615-23.
  92. Misra M, Soyka LA, Miller KK, Herzog DB, Grinspoon S, de Chen D, Neubauer G, Klibanski, A. Serum Osteoprotegerin in Adolescent Girls with Anorexia Nervosa. J Clin Endocrinol Metab. 2003;88:3816-22.
  93. Misra M, Soyka LA, Miller KK, Grinspoon S, Klibanski A. Body Composition Changes with Weight Recovery in Adolescents with Anorexia Nervosa. Am J Clin Nutr. 2003;77:1361 – 1367.
  94. Misra M, McLaughlin D, Donahoe P, Lee MM. The role of Mullerian Inhibiting Substance in the Evaluation of Phenotypic Female Patients with Mild Degrees of Virilization. J Clin Endocrinol Metab. 2003;88:787-92.
  95. Soyka L, Misra M, Frenchman A, Miller, KK, Grinspoon S, Schoenfeld D, Klibanski A. Abnormal Bone Mineral Accrual in Adolescent Girls with Anorexia Nervosa. J Clin Endocrinol Metab. 2002;87:4177-85.
  96. Misra M, McLaughlin D, Donahoe P, Lee MM. Measurement of MIS Facilitates Management of Boys with Microphallus and Cryptorchidism. J Clin Endocrinol Metab. 2002;87:3598-3602.
  97. Misra M, Vavre S, Sharda MH. A Comparative Study of Intracervical PGE2 Gel and Intravenous Oxytocin in Induction of Labor before Term. Singapore J Obstet Gynecol. 1995;26:37-40.
  98. Misra M, Sharda MH, Mishra S. Epidemiology of LBW in an Industrial Hospital in India. J Trop Pediatr. 1995;41:001-2. PMID:8606450
  99. Misra M, Vavre S. Labor Induction with Intracervical PGE2 Gel and Intravenous Oxytocin in Women with a Very Unfavorable Cervix. Aust NZ J Obstet Gynecol. 1994;34:511-6.
  100. Misra M, Matah M, Gupta RM. Cell Mediated and Humoral Immunity in Abortions. Antiseptic. 1994;91:454-7.
  101. Misra M, Matah, M, Gupta RM. Immunology of Primary and Secondary Aborters. Singapore J Obstet Gynecol. 1993;24:112-6.

Other Peer-reviewed Publications (case reports, proceedings of meetings)

  1. Misra M, Parangi S, Ross D, Sadow P, Shailam R. Case records of the Massachusetts General Hospital: Case 38-2010: a 13-year-old girl with an enlarging neck mass. New Eng J Med 2010;363(25):2445-54. PMID: 21158661
  2. Smith E, Loeffler J, Misra M, Pomerantz S, Stemmer-Rachamimov A, Post M. Case records of the Massachusetts General Hospital: Case 37-2008. A 17-year-old boy with a pituitary tumor and skull abnormalities. New Eng J Med 2008;359(22):2367-77. PMID: 1903888
  3. Goldstein MA, Herzog DB, Misra M, Sagar P. Case records of the Massachusetts General Hospital. Case 29-2008. A 19-year-old man with weight loss and abdominal pain. New Eng J Med 2008; 359(12): 1272-1283. PMID: 18799562
  4. Gupta P, Goyal S, Gonzalez-Mendoza LE, Noviski N, Vezmar M, Braithwaite CD, Misra M. Corticotropin-Independent Cushing Syndrome in a Child with an Ovarian Tumor Misdiagnosed as Nonclassic Congenital Adrenal Hyperplasia. Endocr Prac 2008; 14(7): 875-9. PMID: 18996816
  5. Misra M, Levitsky LL. Intermittent Growth Attenuation: Is This A Sign Of Craniopharyngioma? J Pediatr Endocrinol Metab 2006;19(8):1033-38. PMID:16995589
  6. Misra M, Agrawal NR. Successful Pregnancy Outcome in a Case of Uterus Didelphys Causing Infertility. Singapore J Obstet Gynecol. 1996;27.
  7. Misra M, Tiwari P, Khanna R. ITP Presenting Primarily as DUB. Singapore J Obstet Gynecol. 1994;25:229-31.
  8. Misra M, Mishra S. A Case of Recurrent Eclampsia. PostGrad Med J 1994;70:769-70. PMID:7831189
  9. Matah M, Khanna R, Misra M. Triplet Pregnancy. Proc Clin Soc IMS, BHU 1993;1:97-8.
  10. Misra M, Rao K. Successful Pregnancy Outcome in a Case of AML. J Obstet Gynecol Ind. 1993;43:134-5.
  11. Matah S, Misra M, Khanna R. Interlocking of Twins. Proc Clin Soc, BHU 1993;1:100-1.
  12. Misra M, Pani S. Repeated Pregnancy Wastage in a Case of Ehlers-Danlos Syndrome. Ind J Clin Prac. 1992;3:54-56.

Reviews, chapters, monographs and editorials

  1. Misra M, Klibanski A. Anorexia Nervosa and Bone. J Endocrinol 2014. In Press.
  2. Misra M, Klibanski A. Eating Disorders and their Effects on Bone Health. In: “Nutrition and Bone Health”, 2nd Edition, Eds.: Holick MF and Jerri Nieves, Totowa, (NJ): The Humana Press, Inc 2014. In Press
  3. Cuttler L, Misra M, Koontz M. Normal and Abnormal Growth. In ‘Endocrinology’ 7th Edition. Eds. Jameson JL and DeGroot LJ. Saunders Elsevier, Philadelphia PA. In Press.
  4. Misra M. Menstrual Health in the Female Athlete. In ‘IOC Handbook on the Female Athlete’. Ed. Mountjoy ML. Wiley Blackwell. In Press.
  5. Misra M, Klibanski A. Endocrine Consequences of Anorexia Nervosa. The Lancet Diabetes and Endocrinology. In Press.
  6. Singhal V, Misra M, Klibanski A. Endocrinology of Anorexia Nervosa in Young People - Recent insights. Curr Opinion Endocrinol Diabetes. 2014;21(1):64-70.
  7. Ackerman KE, Misra M. Nutrition in Sports Medicine. Nutrition in Pediatrics. 5th Edition. Eds. Duggan CP, Watkins JB, Koletzko B and Walker WA. 2013. In Press.
  8. Misra M, Klibanski A. Anorexia Nervosa, Obesity and Bone Metabolism. Pediatr Endocr Rev 2013;11(1):21-33
  9. Katzman DK, Misra M. Bone Health in Adolescent Females with Anorexia Nervosa: What’s a Clinician to do? Int J Eat Disord 2013; 46(5):456-60.
  10. Misra M. Neuroendocrine Mechanisms in Athletes. In "Clinical Neuroendocrinology", Handbook of Clinical Neurology series. Eds. Fliers E, Korbonits M, Romijn H. Elsevier. 2012 In Press.
  11. Savgan-Gurol E, Misra M. Eating disorders in adolescence and their effect on ovarian function. In ‘PCOS in Adolescence’. Eds: Livadas and Diamanti-Kandarakis. Research Signpost 2012 In press.
  12. Misra M. Effects of Hypogonadism on Bone Metabolism in Adolescent and Young Adult Women. Nature Reviews Endocrinology 2012;8(7):395-404. PMID: 22271187
  13. Balhara B, Misra M, Levitsky LL.  Recombinant human IGF-1 (Insulin-like Growth Factor) Therapy: Where do we stand today? For special supplement on ‘Growth Hormone’. Ind J Pediatr 2012;79(2):244-9. PMID: 22090255
  14. Valassi E, Biller BMK, Klibanski A, Misra M.  Adipokines and Cardiovascular Risk in Cushing’s Syndrome. Neuroendocrinology 2012;95(3):187-206. PMID:22057123
  15. Misra M, Klibanski A. Bone Health in Anorexia Nervosa. Curr Opin Endocrinol Diabetes 2011; 18(6):376-82. PMID: 21897220
  16. Marino R, Misra M. Bone Health and Primary Ovarian Insufficiency. In Seminars in Reproductive Medicine. Larry Nelson. Ed. 2011; 29(4):317-27. PMID: 21969266
  17. Misra M. Vitamin D Deficiency in Children. In: UpToDate, Rose, BD (Ed), UpToDate, Waltham, MA, 2011
  18. Misra M, Klibanski A. Bone Metabolism in Adolescents with Anorexia Nervosa. J Endocrinol Invest 2011;34(4):324-32. Epub 2011 Feb 7. PMID: 21301203
  19. Katz M, Misra M. Delayed Puberty, Short Stature and Tall Stature. The MassGeneral Hospital for Children Adolescent Medicine Handbook. Ed. Goldstein MA. Springer New York Dordrecht Heidelberg London 2010; 147-154.
  20. Ackerman KE, Misra M. Bone health and the female athlete triad in adolescent athletes. The Physician and Sports Medicine 2011;39(1):131-41. PMID: 2137849.
  21. Misra M, Klibanski A. The Neuroendocrine Basis of Anorexia Nervosa. Neuroendocrinology 2011;93(2):65-73. PMID: 21228564
  22. Misra M, Cuttler L. Normal and Abnormal Growth. In ‘Endocrinology’ 6th Edition. Eds. Jameson JL and DeGroot LJ. Saunders Elsevier, Philadelphia PA 2010; 479-516.
  23. Russell M, Misra M. Influence of Ghrelin and Adipocytokines on Bone Mineral Density in Adolescent Female Athletes with Amenorrhea and Eumenorrheic Athletes. In ‘Physical Activity, Cytokines and Growth Mediators in Childhood and Adolescence’ Eds. Hills A, Jürimäe J and Jürimäe T. Med Sport Sci. 2010;55:103-13. PMID: 20956863
  24. Jacobson-Dickman E, Misra M. Skeletal Abnormalities in Anorexia Nervosa. IBMS BoneKey 2010;7:63-83.
  25. Misra M, Klibanski A. Neuroendocrine Consequences of Anorexia Nervosa in Adolescents. Endocr Dev. 2010;17:197-214. PMID: 19955768
  26. Nguyen V, Misra M. Transitioning of children with GH deficiency to adult dosing: Changes in body composition. Pituitary 2009;12(2):125-135.
  27. Levitsky LL, Misra M, Boepple PA, Hoppin A. Adolescent Obesity and Bariatric Surgery. Curr Opin Endocrinol Diabetes Obes. 2009;16(1):37-44.
  28. Misra M. What is the best strategy to combat low bone density in functional hypothalamic amenorrhea? Practice Point. Nature Clin Prac Endocrinol Metab. 2008;4(10):542-3
  29. Misra M. Long-term Skeletal Effects of Eating Disorders with Onset in Adolescence. Annals NY Acad Sci 2008;1135(1):212-8
  30. Prabhakaran R. Misra M. Osteoporosis in Anorexia Nervosa. Future Rheumatology 2008; 3(3):281-296
  31. Misra M. Bone Density in the Adolescent Athlete. Rev Endocr Metab Disord 2008; 9(2):139-44
  32. Stanley T, Misra M. Polycystic Ovarian Syndrome in Obese Adolescents. Curr Opin Endocrinol Diabetes Obes. 2008;15(1):30-6.
  33. Stanley T, Prabhakaran R, Misra M. Pituitary Tumors in Children. Contemporary Endocrinology. Pituitary Tumors: Diagnosis and Management. Eds.: Swearingen B, Biller BMK. Humana Press Inc. Totowa, NJ 2008; p 411-444.
  34. Misra M, Singhal A, Campbell DE. Thyroid Storm. eMedicine from WebMD. (since 2006) Updated January 05, 2010. Available at: http://emedicine.medscape.com/article/925147-overview
  35. Misra M, Klibanski A. Anorexia Nervosa and Osteoporosis. Rev Endocr Metab Disord. 2006;7(1-2):91-9
  36. Levitsky LL, Misra M. Type 1 Diabetes. In: UpToDate, Rose, BD (Ed), UpToDate, Waltham, MA, 2006
  37. Jacobson-Dickman E, Misra M. Gonadal Disorders. Gellis and Kagan’s Current Pediatric Therapy 18th edition. Eds.: Burg FD, Ingelfinger JR, Polin RA and Gershon AA, W.B. Saunders Company, Philadelphia, PA 2006; 980-9.
  38. Prabhakaran R, Misra M. Disorders of Puberty. Gellis and Kagan’s Current Pediatric Therapy 18th edition. Eds.: Burg FD, Ingelfinger JR, Polin RA and Gershon AA, W.B. Saunders Company, Philadelphia, PA 2006; 341-6.
  39. Misra M. Growth Hormone Treatment: Transitioning Care from Adolescence to Adulthood. MGH Neuroendocrine Clinical Center Bulletin 2005:11(2); 6-9.
  40. Misra M, Papakostas GI, Klibanski A. Effects of psychiatric disorders and psychotropic medications on prolactin and bone metabolism. J Clin Psychiatry. 2004;65(12):1607-18; quiz 1590, 1760-1.
  41. Misra M., Lee MM. Intersex Disorders. In: Pediatric Endocrinology: The Requisites in Pediatrics, ed. Thomas Moshang, Jr., M.D. St. Louis (MO): Elsevier Mosby;2004. p. 103-24.
  42. Misra M, Klibanski A. Eating Disorders and their Effects on Bone Health. In: In “Nutrition and Bone Health”, eds.: Holick MF and Dawson-Hughes B. Totowa, (NJ): The Humana Press, Inc.;2004. p. 617-34.
  43. Misra M., Lee MM. Delayed Puberty. In: Pediatric Endocrinology: The Requisites in Pediatrics, ed. Thomas Moshang, Jr., M.D. St. Louis (MO): Elsevier Mosby;2004. p. 87-102.
  44. Lee MM, Misra M, Donahoe PK, MacLaughlin DT. MIS/AMH in the assessment of cryptorchidism and intersex conditions. Mol Cell Endocrinol. 2003;211(1-2):91-8.
  45. Misra M, Klibanski A. Evaluation and treatment of low bone density in anorexia nervosa. Nutr Clin Care. 2002;5(6):298-308.
  46. Misra M, Levitsky LL, Lee MM. Transient hyperthyroidism in an adolescent with hydatidiform mole. J Pediatr. 2002;140(3):362-6.
  47. Misra M, Lee MM. Gonadal Disorders. In: Gellis and Kagan’s Current Pediatric Therapy Eds.: Burg FD, Ingelfinger JR, Polin RA and Gershon AA. Philadelphia (PA): W.B. Saunders Company;2002. p. 698-704.
  48. Misra M, Park-Bennett S. Disorders of Puberty. In: Gellis and Kagan’s Current Pediatric Therapy Eds.: Burg FD, Ingelfinger JR, Polin RA and Gershon AA. Philadelphia (PA): W.B. Saunders Company;2002. p. 706-10.
  49. Misra M. Screening for Carcinoma Cervix-A Review. Ind J Clin Prac. 1994;4:23-6.
  50. Misra M, Pani S. Diagnosis and Management of Diabetes in Pregnancy. Ind J Clin Prac. 1992;3:20-23.

Clinical Guidelines and Reports

 

  1.  Clinical Protocol

DeSouza MJ, Nattiv A, Joy E, Misra M, Williams NI, Mallinson RJ, Gibbs JC, Olmsted M, Goolsby M, Matheson G Expert Panel.  2014 Female Athlete Triad Coalition Consensus Statement on Treatment and Return to Play of the Female Athlete Triad: 1st International Conference held in San Francisco, California, May 2012 and 2nd International Conference held in Indianapolis, Indiana, May 2013. Br J Sports Med 2014; 48:289-308.

I was a member of the committee within the Female Athlete Triad Coalition that developed these guidelines, and my co-authors and I contributed equally to this work.

  1. Clinical Protocol
    Geller D, Pacaud D, Gordon CM, Misra M on behalf of the Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society. State of the Art Review: Emerging Therapies: The Use of Insulin Sensitizers in the Treatment of Adolescents with Polycystic Ovary Syndrome (PCOS). Int J Pediatr Endocrinol 2011;2011:9. PMID: 21899727
    I was a member of the subcommittee within the Drugs and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society that developed these guidelines, and my co-authors and I contributed equally to this work.
  2. Clinical Protocol
    Misra M, Pacaud D, Petryk A, Collett-Solberg P, Kappy M, on behalf of the Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society. Vitamin D Deficiency in Children and its Management: Review of Current Knowledge and Recommendations. Pediatrics 2008; 122: 398-417.  PMID:18676559
    I was the Chair of the subcommittee within the Drugs and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society that developed these guidelines, and led this effort including editing and finalizing the manuscript.
  3. Standard of Care
    Collett-Solberg P, Misra M on behalf of the Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society. The role of rhIGF-I in treating children with short stature. J Clin Endocrinol Metab. 2008;93(1):10-8. PMID:18165284
    I was a member of the subcommittee within the Drugs and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society that developed these guidelines, and my co-author and I contributed equally to this work.

Thesis

 

  1. Misra M. Humoral and cell-mediated immunity in spontaneous, threatened and habitual abortions. IMS, India, 1991. Varanasi (UP), India: Inst. Med. Sci., BHU;1991.

Abstracts, Poster Presentations and Exhibits Presented at Professional Meetings 

 

  1. Misra M, Katzman DK, Clarke H, Miller KK, Klibanski A. Hip Structural Analysis in Adolescent Boys with Anorexia Nervosa and Controls. Joint Meeting of the PES/ESPE at Milan, Italy 2013

Featured Poster 

  1. Ackerman KE, Pierce L, Guereca G, Slattery M, Misra M. Impact of athletic activity vs. hypogonadism on regional body composition, hemodynamic and hematological parameters, and liver function tests. Joint Meeting of the PES/ESPE at Milan, Italy 2013

Featured Poster

  1. Ackerman KE, Nazem T, Patel KT, Ouelette M, Huguenel B, Shimodaira K, Pierce L, Guereca G, Hubbard J, Holmes TM, Anderson EJ, Misra M. Macro- and micronutrient intake is associated with bone density in young athletes and non-athletes. ACSM meeting at Indianapolis, IN 2013
    Featured Poster
  2. Lawson EA, Ackerman KE, Slattery M, Marengi D, Pierce L, Guereca G, Misra M. Oxytocin Secretion is Related to Energy Availability and Expenditure in Young Female Athletes. Endocrine Society meeting at San Francisco, CA 2013
  3. Baskaran C, Misra M, Levitsky LL, Stanley TA. Childhood obesity assessment and management in the primary care setting: A mission unaccomplished. PAS meeting at DC, 2013
  4. Yip C, López X, Woo M, Sherry N, Misra M, Levitsky LL.  Glycemic Control, Insulin Pump Use, and Socioeconomic Status in Hispanic (H) Children with Type 1 Diabetes Mellitus (DM1). PAS meeting at Boston, MA 2012.

 

Pediatric Endocrine-Neuroendocrine-Sports Endocrine Research

0 Emerson Place, Suite 2G
Boston, MA 02114

Phone: 617-724-5602
Fax: 617 726 8528

Public Transportation Access: yes
Disabled Access: yes

Hannah Clarke
Research Coordinator
617-724-6046
hclarke@partners.org

Madhusmita Misra, MD
Director, MGH Pediatric Endocrine-Neuroendocrine-Sports Endocrine Research Lab
617-724-5802
mmisra@partners.org

patient

What will we discover next?

Learn how researchers at MassGeneral Hospital for Children are finding new treatments that advance pediatric care.