Research Centers

Pediatric Endocrine-Neuroendocrine-Sports Endocrine Research

Research within the Pediatric Endocrine-Neuroendocrine-Sports Endocrine Lab aims to further medical knowledge about common endocrine issues in athletes and girls with low-weight eating disorders. In particular, we focus our efforts on establishing findings that lead to the adaptation and improvement of medical care for female athletes and young girls and women with eating disorders.

Sports Endocrine Research

Female Athlete Study: the female athlete triad is the interrelationship of low energy availability, menstrual dysfunction and decreased bone mineral density. Many young female athletes are afflicted with some aspect of this condition. Up to 69% of women participating in sports involving running activities and other endurance sports experience menstrual dysfunction, as compared to only 2-5% of the general population. A major concern associated with the female athlete triad is low bone mineral density. Decreased bone mineral density has been reported in 22-50% of female athletes as compared to 12% of the normal population. Decreased bone mineral density during adolescence puts these athletes at higher risk for fracture. Therefore, it is imperative to address this serious and widespread issue.

Photo of VO2 endurance test

Bionutritionist Tara Holmes obtaining readings during the VO2 endurance test.

Our research group has made significant progress in investigating this condition within a population of teenage girls and young adult women. In an effort to adapt the treatment model for this disorder, we hope to further elucidate the factors that lead to menstrual dysfunction in some but not all athletes. We are also exploring associations of components of the triad with hormone levels, body composition, and bone structure and strength.

Current research studies are aimed at further investigating:

  • the effect of a replacement dose of estrogen and progesterone on bone mineral density, bone structure and strength
  • a possible difference in efficacy of transdermal versus oral estrogen on bone
  • cross-sectional differences among amenorrheic athletes, eumenorrheic athletes, and non-athletes related to:
    • genetic predisposition
    • body composition
    • energy availability
    • cognitive ability
    • fracture risk
  • depression and anxiety in athletes with and without menses to evaluate the role of estrogen versus exercise in improving mood through fMRI testing

Anorexia Nervosa

Bone Health Study: our group has demonstrated that low bone density is prevalent in adolescent girls and boys with anorexia nervosa and is associated with decreased bone turnover. Hormonal alterations that predict low bone density in this disorder include hypogonadism, a nutritionally acquired resistance to growth hormone effects, and high cortisol levels. Weight gain and resumption of menses are associated with some improvement in bone parameters, however, residual deficits persist, raising concerns regarding inadequate catch-up and suboptimal peak bone mass acquisition. Studies exploring possible therapeutic strategies to improve bone density in teenagers with anorexia nervosa are ongoing.The unit is currently investigating the efficacy of IGF-1 on increasing bone density, while also providing supplements proven to help maintain bone density.

Low-Weight Eating Disorders

Brain Study: Eating disorders are heterogeneous illnesses characterized by aberrant behaviors of extreme dietary restriction, binge eating, and purging. The course often involves adolescent onset, and in more than half of individuals, transition from predominantly restrictive to binge/purge behaviors. The pathophysiology of low- weight eating disorders and mechanisms that underlie restricting vs. binge/purge phenotypes are almost entirely unknown. A critical knowledge gap is the neurobiology underlying the developmental trajectory of these illnesses (e.g. transition from primary restriction to binge eating or purging). Our group is now examining homeostatic and hedonic food motivation pathways using functional MRI in relation to appetite regulating hormones and eating behaviors in girls 10-21 years old with low-weight eating disorder behaviors in order to determine predictors of long-term trajectories of these disorders.

Obesity

Our group has demonstrated that growth hormone and cortisol status are important determinants of visceral fat and cardiometabolic risk in teenagers with obesity. We are currently evaluating the effect of low dose growth hormone administration on body composition and cardiometabolic risk in obese adolescent girls.

Autism Spectrum Disorders

Our group has shown that peripubertal boys with autism spectrum disorder (ASD) have lower bone mineral density than typically developing controls, and that both children and adults with ASD are at a higher risk of fracture than controls. We are now examining long term bone accrual rates in boys with ASD.

For more information, please visit the Pediatric Neuroendocrine website.

Neuroendocrine
Anne Klibanski, MD Anne Klibanski, MD
Laurie Carrol Guthart Professor of Medicine, Harvard Medical School
Chief, Neuroendocrine Unit, Massachusetts General Hospital
Phone: 617-726-3870       Fax: 617-726-5072
Pediatric Endocrine
Madhusmita (Madhu) Misra, MD, MPHMadhusmita (Madhu) Misra, MD, MPH
Director, Pediatric Endocrine-Neuroendocrine-Sports Endocrine Research
Professor of Pediatrics, Harvard Medical School
Program Director, Pediatric Endocrinology, MassGeneral Hospital for Children
Associate Chair, MGHfC Research Council
Associate Director, HCCRC, Harvard Catalyst
Pediatrician, MassGeneral Hospital for Children
Phone: 617-726-3870       Fax: 617-726-8528        E-mail: mmisra@mgh.harvard.edu
Sports Medicine and Endocrinology
Kathryn Ackerman, MD, MPHKathryn Ackerman, MD, MPH
Assistant Professor in Medicine, Harvard Medical School
Assistant in Medicine, Massachusetts General Hospital
Associate Director, Pediatric Endocrine-Neuroendocrine-Sports Endocrine Research
Phone: 617-726-7528     Fax: 617 726 8528        E-mail:keackerman@partners.org
Clinical Research Fellow
Vibha Singhal, MD
Phone: 617-726-1428     Fax: 617-726-8528
Nurse Practitioner
Meghan Slattery, NPMeghan Slattery, NP
Phone: 617-643-0267   Fax: 617-726-8528        E-mail: mslattery@partners.org

Study Coordinators and Assistants

Ryan Woolley
Phone: 617-724-6046   Fax: 617-726-8528        E-mail: rwoolley@mgh.harvard.edu

Shreya Tulsiani
Phone: 617-643-0266   Fax: 617-726-8528       E-mail: stulsiani@mgh.harvard.edu

Chris Mancuso
Phone: 617-643-7847   Fax: 617-726-8528       E-mail: cmancuso@partners.org

Female Athlete Study

Frequently Asked Questions

    1. Will scheduling be a problem since I’m a full-time student?

    We understand that most participants are in high school or college and have very busy schedules. We respect your time commitments and work hard to plan visits around your schedules so that participants do not have to miss their classes, jobs, or team commitments. For example, some visits can take place on your campus and we can see participants at MGH on weekends.

    2. I will be out of town for the summer months. Will that be an issue for scheduling my visits?

    Not at all! Visits may occur at 1.5 or 3 month intervals so we can coordinate visits when you are here, or at facilities closer to you. If you let us know ahead of time when you’ll be away, we can work out the dates so they fit best with your schedule.

    3. Is it safe for me to participate?

    All the components of this study have been approved by a human safety board called the Institutional Review Board to ensure that the protocol and all the procedures we do are safe for participants. Additionally, all medications given to participants are natural hormones given in replacement doses.

    6. What is the METCART assessment/indirect calorimetry test?

    A metabolic cart assessment, sometimes referred to as indirect calorimetry, is used to estimate the number of calories burned by the body in a resting state.  After a 2-hour fast (no food or beverages except water), the participant is instructed to lie down and a clear plastic hood or “canopy” is placed over her head.  For the next 20 minutes, she simply lies still and breathes normally while the machine collects and analyzes her breath, providing an estimate of her metabolic rate. This test provides information for all patients about their metabolism, and by being a part of the study, all participants get to keep the results from this assessment.

    7. What is the purpose of the CT scan?

    The CT scan is an imaging study that helps us visualize the structure of bones at a microscopic level. This gives us a more detailed picture of bone than a DXA does, and may better predict fracture risk. The CT scan will help us determine how bone structure is affected by hormonal changes in female athletes and females affected with anorexia nervosa.

    8. How does the fMRI scan work?

    The term fMRI stands for functional MRI. This means that the MRI scan is done when the subject is actually doing some tasks (and hence the term functional). This scan helps us visualize the brain when subjects perform some tasks in the scanner. We will be using tasks which will activate areas of the brain involved in depression and anxiety.  

    The scans take place at the Martinos Center in Charlestown. You can either meet the study coordinator at the center or take a shuttle from the MGH main campus with the coordinator.

    Once there you will be asked to change into scrubs and remove all metal before entering the scanner. The study staff will help you into the machine where you will be lying down and looking at a screen. The scan will take about an hour and during the scans you will be responding to behavioral tasks presented on the screen.

    After the scans are complete the study staff will help you out of the scanner and you will be asked to answer a few related questionnaires.

    Other Studies

  • Fat Mediated Modulation of Reproductive and Endocrine Function in Young Athletes
  • Effects of Anorexia Nervosa on Peak Bone Mass
  • Effect of Growth Hormone on Visceral Fat and Cardiovascular Risk Markers in Obese Teenage Girls
  • Homeostatic and Hedonic Food Motivation Underlying Eating Disorder Trajectories

For more information, please visit the Pediatric Neuroendocrine website.

Bibliography

Research Investigations

  1. Cartaya J, Misra M. The Low Dose ACTH Stimulation Test: Is 30 Minutes Long Enough? Endocr Pract. 2015 Feb 9:1-21 In Press.
  2. Ackerman KE, Sokoloff NC, Maffazioli G, Clarke HM, Lee H, Misra M. Fractures in Relation to Menstrual Status and Bone Parameters in Young Athletes. Med Sci Sports Exerc. 2014. In Press.
  3. Baskaran C, Misra M, Levitsky LL. Diagnosis of Pediatric Hyperthyroidism: Technetium 99 Uptake vs. Thyroid Stimulating Immunoglobulins (TSI). Thyroid 2015; 25(1):37-42. PMCID: PMC429109
  4. Slattery MJ, Bredella MA, Stanley T, Torriani M, Misra M. Effects of recombinant Human Growth Hormone (rhGH) Administration on Body Composition and Cardiovascular Risk Factors in Obese Adolescent Girls. Int J Pediatr Endocrino 2014;2014 (1):22. PMCID: PMC4247194
  5. Neumeyer A, O’Rourke JA, Massa A, Lee H, Lawson EA, McDougle CJ, Misra M. Bone Fractures in Children and Adults with Autism Spectrum Disorders. J Autism Develop Disord 2014. In Press.
  6. Singhal V*, Eguiguren M*, Ackerman KE, Slattery M, Misra M. Body Composition, Hemodynamic and Biochemical Parameters in Young Female Normal-Weight Oligo-amenorrheic and Eumenorrheic Athletes and Non-athletes. Ann Nutr Metab 2014;65:264-271. PMCID: PMC4268142
  7. Singhal V, Lawson EA, Ackerman KE, Fazeli PK, Clarke H, Lee H, Eddy K, Marengi DA, Derrico NP, Bouxsein ML, Misra M.  Irisin Levels are Lower in Young Amenorrheic Athletes Compared with Eumenorrheic Athletes and Non-Athletes and are Associated with Bone Density and Strength Estimates. PLoS ONE 2014;13:9(6):e100218. PMCID:PMC4057451
  8. Lawson EA, Ackerman KE, Slattery M, Marengi D, Clarke H, Misra M.  Oxytocin secretion is related to measures of energy homeostasis in young amenorrheic athletes. J Clin Endocrinol Metab 2014;99(5):E881-5. PMCID: PMC4010698
  9. Eddy KT, Lawson EA, Meade C, Meenaghan E, Horton SE, Misra M, Klibanski A, Miller KK. Appetite regulatory hormones in women with anorexia nervosa-binge/purge vs. restricting type. J Clin Psychiatry 2015; 76(1):19-2.
  10. Corey KE, Stanley TL, Misdraji J, Scirica C, Pratt J, Hoppin A, Misra M. Prevalence and Outcome of Nonalcoholic Fatty Liver Disease in Adolescents and Young Adults Undergoing Weight Loss Surgery. Pediatr Obes 2014 Oct;9(5):e91-3. PMCID: PMC4163105.
  11. Fazeli PK, Wang IS, Miller KK, Herzog DB, Misra M, Lee H, Finkelstein JS, Bouxsein ML, Klibanski A. Teriparatide increases bone formation and bone mineral density in adult women with anorexia nervosa. J Clin Endocrinol Metab 2014;99(4):1322-9. PMCID: PMC3973785
  12. Faje AT, Fazeli PK, Miller KK, Katzman DK, Ebrahimi S, Lee H, Mendes N, Snelgrove D, Meenaghan E, Misra M, Klibanski A. Fracture Risk and Areal Bone Mineral Density in Adolescent Females with Anorexia Nervosa. Int J Eating Disord 2014; 99(4):1322-9. PMCID:PMC4053520
  13. Slattery M, Bredella M, Misra M. Insulin Resistance and Impaired Mitochondrial Function in Obese Adolescent Girls. Metab Syndr Relat Disord 2014;12(1):56-61. PMCID: PMC3942687.
  14. Phan CM, Khalilzadeh O, Dinkel J, Wang I, Bredella MA, Misra M, Miller KK, Klibanski A, Gupta R. C-arm CT for histomorphometric evaluation of lumbar spine trabecular microarchitecture: a study in Anorexia Nervosa patients. Br J Radiol 2013; 86(1027):20120451. PMCID: PMC3922178
  15. Misra M. Katzman DK, Clarke H, Snelgrove D, Brigham K, Miller KK, Klibanski A. Hip Structural Analysis in Adolescent boys with Anorexia Nervosa and Normal-Weight Controls. J Clin Endocrinol Metab 2013; 98(7):2952-8. PMCID:PMC3701273
  16. Misra M, Katzman DK, Estella NM, Eddy K, Miller KK, Klibanski A. Impact of Estrogen Replacement Therapy on Anxiety Symptoms, Body Shape Perception and Eating Attitudes in Adolescent Girls with Anorexia Nervosa. J Clin Psychiatr 2013;74(8):e765-71. PMCID: PMC4017248
  17. Faje A, Karim L, Taylor A, Lee H, Miller KK, Mendes N, Meenaghan E, Bouxsein ML, Misra M, Klibanski A Adolescent Girls with Anorexia Nervosa have Impaired Cortical and Trabecular Microarchitecture and Lower Estimated Bone Strength at the Distal Radius. J Clin Endocrinol Metab 2013;98(5):1923-9. PMCID: PMC3644600.
  18. Ackerman KE, Pierce L, Guereca G, Slattery M, Lee H, Goldstein M, Misra M. Hip Structural Analysis in Adolescent and Young Adult Oligo-amenorrheic and Eumenorrheic Athletes and Non-athletes. J Clin Endocrinol Metab 2013; 98(4):1742-9 PMCID: PMC3615200.
  19. Faje A,  Fazeli PK, Katzman D, Miller KK, Breggia A, Rosen CJ, Mendes N, Misra M, Klibanski A. Inhibition of Pref-1 by Estradiol in Adolescent Girls with Anorexia Nervosa is Associated with Improvement in  Lumbar Bone Mineral Density. Clin Endocrinol (Oxf). 2013;79(3):326-32. PMCID:PMC364065
  20. Fazeli PK, Ackerman KE, Pierce L, Guereca G, Bouxsein M, Misra M. Sclerostin and Pref-1 have Differential Effects on Bone Mineral Density and Strength Parameters in Adolescent Athletes Compared with Non-athletes. Osteoporos Int 2013; 24(9):2433-40. PMCID:PMC3740025
  21. McManus S, Levitsky LL, Misra M. Adolescents with Polycystic Ovary Syndrome: Normal-Weight and Overweight Phenotypes. Endocr Pract. 2013;19(3):471-478. PMID: 23816935.
  22. Lawson EA, Ackerman KE, Estella NM, Guereca G, Pierce L, Sluss PM, Bouxsein ML, Klibanski A, Misra M. Nocturnal Oxytocin Secretion is Lower in Amenorrheic Athletes than Non-Athletes and Associated with Bone Microarchitecture and Finite Element Analysis Parameters. European J Endocrinol 2013;168(3):457-64. PMCID:PMC3679669
  23. Sinha M, Stanley TL, Webb J, Scirica C, Corey K, Pratt J, Boepple PA, Hoppin A, Misra M. Metabolic Effects of Roux-en-Y Gastric Bypass in Obese Adolescents and Young Adults. J Pediatr Gastroenterol Nutr 2012;56(5):528-31.PMCID:PMC3637417
  24. Fazeli P, Mendes N, Russell M, Herzog DB, Klibanski A, Misra M. Bone Density Characteristics and Major Depressive Disorder in Adolescents. Psychosomatic Med 2013;75(2):117-23PMCID: PMC3570708
  25. Neumeyer AM, Gates A, Ferrone C, Lee H, Misra M. The Effect of Autism on Bone Metabolism in Peripubertal Boys. J Autism Develop Disord 2013;43(7):1623-9PMID:23124396.
  26. Stanley T, Bredella M, Mendes Estella N, Pierce L, Misra M.  The Ratio of Parathyroid Hormone to Vitamin D is a Determinant of Cardiovascular Risk and Insulin Sensitivity in Adolescent Girls. Metab Syndr Relat Disord. 2013;11(1):56-62. PMCID: PMC3593691
  27. Bredella M, McManus S, Misra M. Impact of Metformin Monotherapy versus Metformin with Oestrogen-Progesterone on Lipids in Adolescent Girls with Polycystic Ovarian Syndrome. Clin Endocrinol 2013: 79, 199–203.  PMID: 22928702
  28. Lawson EA*, Fazeli PK*, Calder G, Putnam H, Misra M, Meenaghan E, Miller KK, Klibanski A. Plasma Sodium Level is Associated with Bone Loss Severity in Women with Anorexia Nervosa. Journal of Clinical Psychiatry 2012;73(11):e1379-83. PMCID: PMC3729037
  29. Ackerman KE, Putman M, Guereca G, Taylor AP, Pierce L, Herzog DB, Klibanski A, Bouxsein M, Misra M. Cortical Microstructure and Estimated Bone Strength in Young Amenorrheic Athletes, Eumenorrheic Athletes and Non-Athletes. Bone 2012; 51(4):680-687. PMCID: PMC3482939.
  30. von Oettingen J, Sola Pou J, Levitsky LL, Misra M. Clinical Presentation of Premature Adrenarche. Clin Pediatr (Phila) 2012;51(12):1140-9. PMID: 22893187.
  31. Faje AT, Fazeli P, Katzman DK, Breggia A, Rosen CJ  Mendes N, Klibanski A, Misra M. Sclerostin Levels and Bone Turnover Markers in Adolescents with Anorexia Nervosa and Normal Adolescent Girls. Bone 2012; 51(3):474-9. PMCID: PMC3412913.
  32. Ackerman KE, Patel K, Guereca G, Pierce L, Herzog DB, Misra M. Cortisol Secretory Parameters in Young Exercisers in Relation to LH Secretion and Bone Parameters. Clin Endocrinol (Oxf) 2013;78(1):114-9. PMCID: PMC3443505.
  33. Ackerman KE, Slusarz K, Guereca G, Pierce L, Slattery M, Mendes N, Herzog DB, Misra M. Higher Ghrelin and Lower Leptin Secretion is Associated with Lower LH Secretion in Young Amenorrheic Athletes Compared with Eumenorrheic Athletes and Controls. Am J Physiol Endocrinol Metab 2012;302(7):E800-6. PMCID:PMC3330709
  34. Fazeli PK, Calder G, Miller KK, Misra M, Lawson EA, Meenaghan E, Lee H, Herzog DB, Klibanski A. Psychotropic Medication Use in Anorexia Nervosa between 1997 and 2009. Int J Eat Disord 2012;45(8):970-6. PMCID:PMC3726215
  35. Ackerman KE, Skrinar GS, Medvedova E, Misra M, Miller KK. Estradiol Levels Predict Bone Mineral Density in Male Collegiate Athletes. Clin Endocrinol (Oxf) 2012;76(3):339-45. PMCID: PMC3274603
  36. Lawson EA, Miller KK, Blum JI, Meenaghan E, Misra M, Eddy KT, Herzog DB, Klibanski A. Leptin Levels Are Associated With Decreased Depressive Symptoms in Women Across the Weight Spectrum, Independent of Body Fat. Clin Endocrinol. 2012;76(4):520-5PMCID: PMC3296868
  37. Ackerman KE*, Nazem T*, Chapko C, Russell M, Mendes N, Taylor AP, Bouxsein ML, Misra M. Bone Microarchitecture is Impaired in Adolescent Amenorrheic Athletes Compared with Eumenorrheic Athletes and Non-Athletic Controls. J Clin Endocrinol Metab 2011;96(10):3123-33. PMCID: PMC3200253
  38. Puzhko S*, Goodyer CG*, Kerachian MA, Canaff L, Misra M, Jüppner H, Bastepe M, Hendy GN. Parathyroid hormone signaling via Gαs is selectively inhibited by an NH2- terminally truncated Gαs: implications for pseudohypoparathyroidism. J Bone Miner Res 2011;26(10):2473-85. PMID: 21713996.
  39. Ackerman KE, Davis B, Jacoby L, Misra M. DXA Surrogates for Visceral Fat are Inversely Associated with Bone Density Measures in Adolescent Athletes with Menstrual Dysfunction. J Pediatr Endocrinol Metab 2011;24(7-8):497-504. PMCID: PMC3652985
  40. Misra M, Katzman DK, Miller KK, Mendes N, Snelgrove D, Russell M, Goldstein MA, Ebrahimi S, Clauss L, Weigel T, Mickley D, Schoenfeld D, Herzog DB, Klibanski A. Physiologic Estrogen Replacement Increases Bone Density in Adolescent Girls with Anorexia Nervosa. J Bone Miner Res 2011;26(10):2430-8PMCID: PMC3304439
  41. Russell M, Breggia A, Mendes N, Klibanski A, Misra M. Growth Hormone is Positively Associated with Surrogate Markers of Bone Turnover during Puberty. Clin Endocrinol 2011;75(4):482-8. PMCID: PMC3722873
  42. Miller KK, Meenaghan E, Lawson EA, Misra M, Gleysteen S, Schoenfeld D, Herzog D, Klibanski A. Effects of Risedronate and Low-Dose Transdermal Testosterone on Bone Mineral Density in Women with Anorexia Nervosa:  A Randomized, Placebo-Controlled Study. J Clin Endocrinol Metab 2011. 96(7):2081-8. PMCID: PMC3135194.
  43. Lawson EA, Donoho DA, Blum J, Meenaghan E, Misra M, Herzog DB, Sluss P, Miller KK, Klibanski A. Decreased Nocturnal Oxytocin Levels in Anorexia Nervosa Are Associated with Low Bone Mineral Density and Fat Mass. J Clin Psychiatr 2011;72(11):1546-51. PMCID:PMC3731046
  44. Balhara B, Misra M, Levitsky LL. Clinical Monitoring Guidelines for Congenital Hypothyroidism:  Laboratory Outcome Data in the First Year of Life. J Pediatr 2011; 158(4):532-7PMID: 21094953
  45. Savgan-Gurol E, Bredella M, Russell M, Mendes N, Klibanski A, Misra M. Waist to hip ratio and trunk to extremity fat (DXA) are better surrogates for IMCL and for visceral fat respectively than for subcutaneous fat in adolescent girls. Nutr Metab (Lond) 2010;7(1):86. PMCID: PMC3018385.
  46. Lawson EA, Eddy K, Donoho D, Misra M, Miller KK, Meenaghan E, Lydecker J, Herzog D, Klibanski A. Appetite Regulating Hormones Cortisol and Peptide YY are Associated with Disordered Eating Psychopathology Independent of Body Mass Index. Eur J Endocrinol 2010;164(2):253-61. PMCID: PMC3677777.
  47. Fazeli PK, Lawson EA, Prabhakaran R, Miller KK, Donoho D, Clemmons DR, Herzog DB, Misra M, Klibanski A. Effects of Recombinant Human Growth Hormone in Anorexia Nervosa: A Randomized, Placebo-Controlled Study. J Clin Endocrinol Metab. 2010;95(11):4889-97. PMCID: PMC2968733
  48. Brick DJ, Gerweck AV, Meenaghan E, Lawson EA, Misra M, Fazeli P, Johnson W,  Klibanski A, Miller KK. Determinants of IGF-1 and GH Throughout the Weight Spectrum:  From Anorexia Nervosa to Obesity. Eur J Endocrinol 2010; 163(2):185-91. PMCID: PMC2953770
  49. Katavetin P, Cheunsuchon P, Grant E, Boepple PA, Hedley-Whyte ET, Misra M, Levitsky LL. Rathke’s Cleft Cysts in Children and Adolescents: Association with Female Puberty. J Pediatr Endocrinol Metab 2010:23(11);1175-80. PMID: 21284332
  50. Walsh CJ, Phan CM, Misra M, Bredella MA, Miller KK, Fazeli P, Bayraktar HH, Klibanski A, Gupta R. Finite Element and Trabecular Structure Analysis in Anorexia Nervosa via Flat-Panel Volume CT. Radiology 2010;257(1):167-74. PMCID: PMC2941723
  51. Misra M, Le Clair M, Mendes N, Miller KK, Lawson EA, Meenaghan E, Weigel T, Ebrahimi S, Herzog DB, Klibanski A. Use of SSRIs may Impact Bone Density in Adolescent and Young Women with Anorexia Nervosa. CNS Spectrums 2010; 15(9):579-586.
  52. Katavetin P, Cheunsuchon P, Swearingen B, Hedley-Whyte ET, Misra M, Levitsky LL Pituitary Adenomas in Children and Adolescents. J Pediatr Endocrinol Metab 2010;23(5): 427-32. PMID: 20662340
  53. Wong KN, Levitsky LL, Misra M. Predictors of Growth Consequences of Central Hypothyroidism in Pediatric Patients Receiving Recombinant Human Growth Hormone. J Pediatr Endocrinol Metab 2010;23(5): 451-62. PMID: 20662344
  54. Lloyd B, Ravi P, Mendes N, Klibanski A, Misra M. Peptide YY Levels across Pubertal Stages and Associations with Growth Hormone. J Clin Endocrinol Metab 2010; 95(6):2957-62. PMCID: PMC2902078
  55. Bredella MA, Ghomi RH, Thomas BJ, Torriani M, Brick DJ, Gerweck AV, Misra M, Klibanski A, Miller KK. Comparison of DXA and CT in the assessment of body composition in premenopausal women with obesity and anorexia nervosa. Obesity (Silver Spring). 2010 Nov;18(11):2227-33. PMCID: PMC3607308
  56. Russell M, Mendes N, Miller KK, Rosen CJ, Klibanski A, Misra M. Visceral Fat is a Negative Predictor of Bone Density Measures in Obese Adolescent Girls. J Clin Endocrinol Metab 2010; 95(3):1247-55. PMCID: PMC2841531
  57. Wojcik MH, Meenaghan E, Lawson EA, Misra M, Klibanski A, Miller KK. Reduced Amylin Levels Are Associated with Low Bone Mineral Density in Women with Anorexia Nervosa. Bone. 2010 Mar;46(3):796-800. PMCID: PMC2824019
  58. Fazeli PK, Misra M, Goldstein M, Miller KK, Klibanski A. FGF-21 May Mediate Growth Hormone Resistance in Anorexia Nervosa. J Clin Endocrinol Metab. 2010;95(1):369-74. PMCID: PMC2805486
  59. Fazeli PK, Bredella MA, Misra M, Meenaghan E, Rosen CJ, Breggia A, Miller KK, Klibanski A. Pref-1 Predicts Marrow Adiposity and Bone Mineral Density in Women with Anorexia Nervosa. Clin Endocrinol Metab. 2010;95(1):407-13. PMCID: PMC2805488
  60. Stanley T, Levitsky LL, Grinspoon S, Misra M. Effect of Body Mass Index on Peak Growth Hormone Response to Provocative Testing in Children with Short Stature. J Clin Endocrinol Metab 2009; 94(12):4875-81. PMCID: PMC2795667
  61. Lawson EA, Miller KK, Donoho D, Misra M, Meenaghan E, Lydecker J, Wexler T, Herzog D, Klibanski A. Hypercortisolemia predicts severity of bone loss, anxiety and depression in hypothalamic amenorrhea and anorexia nervosa. J Clin Endocrinol Metab 2009;94(12):4710-6. PMCID: PMC2795653
  62. Lawson EA, Miller KK, Bredella MA, Phan C, Misra M, Meenaghan E, Rosenblum L, Donoho D, Gupta R, Klibanski A. Hormone Predictors of Abnormal Bone Microarchitecture in Women with Anorexia Nervosa. Bone 2009; 6(2):458-63. PMCID: PMC2818221
  63. Misra M, McGrane J, Miller KK, Goldstein MA, Ebrahimi S, Weigel T, Klibanski A. Effects of rhIGF-1 Administration on Surrogate Markers of Bone Turnover in Adolescents with Anorexia Nervosa. Bone 2009; 45:493-8. PMCID: PMC3590307
  64. Russell M, Bredella M, Tsai P, Mendes N, Miller KK, Klibanski A, Misra M. Relative Growth Hormone Deficiency and Cortisol Excess are Associated with Increased Cardiovascular Risk Markers in Obese Adolescent Girls. J Clin Endocrinol Metab 2009; 94:2864-71. PMCID: PMC2730871
  65. Russell M, Stark J, Nayak S, Miller KK, Herzog DB, Klibanski A, Misra M Peptide YY in Adolescent Athletes with Amenorrhea, Eumenorrheic Athletes and Non-Athletic Controls. Bone 2009;45(1):104-9. PMCID: PMC2692763.
  66. Bredella M, Fazeli PK, Miller KK, Misra M, Torriani M, Thomas BJ, Ghomi RH, Rosen CJ, Klibanski A. Increased Bone Marrow Fat in Anorexia Nervosa. J Clin Endocrinol Metab 2009; 94(6):2129-36. PMCID: PMC2690416
  67. Misra M, Tsai P, Mendes N, Miller KK, Klibanski A. Increased Carbohydrate Induced Ghrelin Secretion in Obese versus Normal-weight Adolescent Girls. Obesity 2009;17(9):1689-95. PMCID: PMC3687036
  68. McCormack S, Mitchell DM, Woo M, Levitsky LL, Ross DS, Misra M. Radioactive Iodine for Hyperthyroidism in Children and Adolescents: Referral Rate and Response to Treatment. Clin Endocrinol 2009; 71(6): 884 – 891. PMID: 19250263
  69. Lawson EA, Misra M, Meenaghan E, Rosenblum L, Donoho DA, Herzog DB, Klibanski A, Miller KK. Adrenal glucocorticoid and androgen precursor dissociation in anorexia nervosa. J Clin Endocrinol Metab 2009; 94(4):1367-71. PMCID: PMC2682472
  70. Taylor C, Lamparello B, Kruczek, K, Anderson E, Hubbard J, Misra M. Validation of a Food Frequency Questionnaire for Calcium and Vitamin D Intake in Adolescent Girls with Anorexia Nervosa. J Amer Diet Assoc 2009;109(3); 497-485;e3. PMCID: PMC2673098.
  71. Misra M, Katzman DK, Cord J, Manning  SJ, Mickley D, Herzog DB, Miller KK, Klibanski A. Percent Extremity Fat, but not Percent Trunk Fat, is Lower in Adolescent Boys with Anorexia Nervosa Compared with Healthy Adolescents. Am J Clin Nutr 2008; 88(6):1478-84. PMCID:PMC3722579
  72. Misra M, Bredella M, Tsai P, Mendes N, Miller KK, Klibanski A. Lower Growth Hormone and Higher Cortisol are Associated with Greater Visceral Adiposity, Intramyocellular Lipids and Insulin Resistance in Overweight Girls. Am J Physiol Endocrinol Metab 2008;295(2):E385-92. PMCID: PMC2519763
  73. Misra M, Katzman DK, Cord J, Manning  SJ, Mendes N, Herzog DB, Miller KK, Klibanski A. Bone Metabolism in Adolescent Boys with Anorexia Nervosa and its Determinants. J Clin Endocrinol Metab 2008;93(8):3029-3036. PMCID: PMC2515086.
  74. Bredella MA, Misra M, Miller KK, Sarwar A, Madisch I, Cheung A, Klibanski A, Gupta R.  Distal Radius in Adolescent Girls with Anorexia Nervosa:Trabecular Structure Analysis with Very High Resolution Flat Panel Volume CT. Radiology. 2008;249(3):938-46. PMCID: PMC2691811
  75. Utz AL, Lawson EA, Misra M, Minihan JL, Lee EE, Mathur VA, Herzog DB, Klibanski A, Miller KK. Peptide YY (PYY) Levels and Bone Mineral Density (BMD) in Women with Anorexia Nervosa. Bone 2008;43(1):135-9. PMCID: PMC2493518.
  76. Christo K, Cord J, Mendes N, Miller KK, Goldstein M, Herzog DB, Klibanski A, Misra M. Acylated Ghrelin and Leptin in Adolescent Athletes with Amenorrhea, Eumenorrheic Athletes and Controls: A Cross-sectional Study. Clin Endocrinol 2008;69(4):628-33. PMCID:PMC3206259.
  77. Prabhakaran R*, Misra M*, Miller KK, K. Kruczek, S. Sundaralingam, Herzog DB, Debra K. Katzman, Klibanski A. Determinants of Height in Adolescent Girls with Anorexia Nervosa. Pediatrics 2008;121(6):e1517-e1523. PMID: 18519455.
  78. Misra M, Prabhakaran P, Miller KK, Tsai P, Goldstein M, Mickley D, Clauss L, Lockhart P, Herzog DB, Katzman D, Klibanski A. Prognostic Indicators of Changes in Bone Density in Adolescent Girls with Anorexia Nervosa and Healthy Adolescents-II. J Clin Endocrinol Metab 2008; 93(4):1292-7. PMCID: PMC2291487.
  79. Misra M, Prabhakaran P, Miller KK, Tsai P, Goldstein M, Mickley D, Clauss L, Lockhart P, Herzog DB, Katzman D, Klibanski A. Weight Gain and Restoration of Menses as Predictors of Bone Mineral Density Change in Adolescent Girls with Anorexia Nervosa-1. J Clin Endocrinol Metab 2008; 93(4):1231-7PMCID: PMC2291495.  
  80. Christo K*, Prabhakaran R*, Lamparello B, Cord J, Miller KK, Goldstein M, Gupta N, Herzog DB, Klibanski A, Misra M. Bone Metabolism in Adolescent Amenorrheic and Eumenorrheic Athletes and Controls. Pediatrics 2008; 121(6):1127-1136. PMCID:PMC3208310
  81. Misra M, Cord J, Prabhakaran R, Miller KK, Klibanski A. Growth Hormone Suppression Following an Oral Glucose Load in Children. J Clin Endocrinol Metab 2007; 92(12):4623-9.
  82. Demura M, Martin RM, Shozu M, Sebastian S, Takayama K, Hsu W, Schultz RA, Neely K, Bryant M, Mendonca BB, Hanaki K, Kanzaki S, Rhoads DB, Misra M, Bulun SE. Regional Rearrangements in Chromosome 15q21 Cause Formation of Cryptic Promoters for the CYP19 (Aromatase) Gene. Hum Mol Genet 2007; 16(21):2529-41.
  83. Lawson EA, Miller KK, Mathur VA, Lee EE, Misra M, Grinspoon S, Herzog DB, Klibanski A. Hormonal and Nutritional Effects on Cardiovascular Risk Markers in Young Women. J Clin Endocrinol Metab 2007;92(8):3089-94.
  84. Miller KK, Wexler TL, Zha A, Lawson EA, Meenaghan E, Misra M, Binstock A, Herzog DB and Klibanski A. Androgen Deficiency:  Association with Increased Anxiety and Depression Symptom Severity in Anorexia Nervosa. J Clin Psychiatry 2007;68(6):959-965
  85. Misra M, Miller KK, Cord J, Prabhakaran R, Goldstein M, Katzman DK, Herzog DB, Klibanski A. Relationships between Serum Adipokines, Insulin Levels and Bone Density in Girls with Anorexia Nervosa. J Clin Endocrinol Metab 2007; 92(6):2046-52.
  86. Miller KK, Lawson LE, Mathur V, Wexler T, Meenaghan E, Misra M, Herzog DB, Klibanski A. Androgens in Women with Anorexia Nervosa and Normal-Weight Women with Hypothalamic Amenorrhea. J Clin Endocrinol Metab 2007;92(4):1334-9.
  87. Misra M, Miller KK, Tsai P, Stewart V, End A, Freed N, Herzog DB, Goldstein M, Riggs S, Klibanski A. Uncoupling of Cardiovascular Risk Markers in Adolescent Girls with Anorexia Nervosa. J Pediatr 2006;149 (6):763-9.
  88. Miller KK, Lee EE, Lawson E, Misra M, Minihan J, Grinspoon SK, Gleysteen S, Mickley D, Herzog DB, Klibanski A. Determinants of Skeletal Recovery in Anorexia Nervosa. J Clin Endocrinol Metab 2006;91(8):2931-7.
  89. Misra M, Tsai P, Anderson EJ, Hubbard J, Gallagher K, Soyka LA, Miller, KK, Herzog DB, Klibanski A. Nutrient Intake in Community Dwelling Adolescent Girls with Anorexia Nervosa and Healthy Adolescents. Am J Clin Nutr 2006;84:698-706.
  90. Misra M, Prabhakaran R, Miller KK, Tsai P, Lin A, Lee N, Herzog DB, Klibanski A. Role of Cortisol in Menstrual Recovery in Adolescent Girls with Anorexia Nervosa. Pediatr Res 2006:59; 598-603.
  91. Misra M, Miller KK, Tsai P, Gallagher K, Lin A, Noel L, Herzog DB, Klibanski A. Elevated Peptide YY Levels in Adolescent Girls with Anorexia Nervosa. J Clin Endocrinol Metab 2006;91:1027-33. Epub 2005 Nov 8.
  92. Misra M, Miller KK, Stewart V, Hunter E, Kuo K, Herzog DB, Klibanski A. Ghrelin and Bone Metabolism in Adolescent Girls with Anorexia Nervosa 2005 J Clin Endocrinol Metab 2005: 90: 5082-5087; Epub 2005 July 5.
  93. Misra M, Miller KK, Kuo K, Griffin K, Stewart V, Hunter E, Herzog DB, Klibanski A. Secretory Dynamics of Leptin in Adolescent Girls with Anorexia Nervosa and Healthy Adolescents 2005 Am J Physiol Endocrinol Metab 289(3):E373-81. Epub 2005 Apr 5.
  94. Misra M, Miller KK, Kuo K, Griffin K, Stewart V, Hunter E, Herzog DB, Klibanski A. Secretory Dynamics of Ghrelin in Adolescent Girls with Anorexia Nervosa and Healthy Adolescents 2005 Am J Physiol: Endocrinol Metab 289(2):E347-56. Epub 2005 Mar 8
  95. Misra M, Miller KK, Almazan C, Worley M, Herzog DB, Klibanski A. Hormonal Determinants of Regional Body Composition in Adolescent Girls with Anorexia Nervosa and Controls. J Clin Endocrinol Metab. 2005;90:2580-7. Epub 2005 Feb 15
  96. Misra M, Aggarwal A, Miller KK, Almazan C, Worley M, Soyka LA, Herzog D, Klibanski, A. Effects of Anorexia Nervosa on Clinical, Hematological, Biochemical and Bone Density Parameters in Community Dwelling Adolescent Girls. Pediatrics. 2004;114:1574-1583.
  97. Misra M, Miller KK, Almazan C, Ramaswamy K, Lapcharoensap W, Worley M, Neubauer G, Herzog DB, Klibanski A. Alterations in Cortisol Secretory Dynamics in Adolescent Girls with Anorexia Nervosa and Effects on Bone Metabolism. J Clin Endocrinol Metab. 2004;89:4972-80.
  98. Misra M, Miller KK, Almazan C, Ramaswamy K, Aggarwal A, Herzog DB, Neubauer G, Breu J, Klibanski A. Hormonal and Body Composition Predictors of Soluble Leptin Receptor, Leptin and Free Leptin Index in Adolescent Girls with Anorexia Nervosa and Controls and Relation to Insulin Sensitivity. J Clin Endocrinol Metab. 2004;89:3486-95.
  99. Misra M, Miller KK, Herzog DB, Ramaswamy K, Aggarwal A, Almazan C, Neubauer G, Breu J, Klibanski A. Growth Hormone and Ghrelin Responses to an Oral Glucose Load in Adolescent Girls with Anorexia Nervosa and Controls. J Clin Endocrinol Metab. 2004;89:1605-12.
  100. Misra M, Miller KK, Bjornson J, Hackman A, Aggarwal A, Chung J, Ott M, Herzog DB, Johnson ML, Klibanski A. Alterations in Growth Hormone Secretory Dynamics in Adolescent Girls with Anorexia Nervosa and Effects on Bone Metabolism. J Clin Endocrinol Metab. 2003;88:5615-23.
  101. Misra M, Soyka LA, Miller KK, Herzog DB, Grinspoon S, de Chen D, Neubauer G, Klibanski, A. Serum Osteoprotegerin in Adolescent Girls with Anorexia Nervosa. J Clin Endocrinol Metab. 2003;88:3816-22.
  102. Misra M, Soyka LA, Miller KK, Grinspoon S, Klibanski A. Body Composition Changes with Weight Recovery in Adolescents with Anorexia Nervosa. Am J Clin Nutr. 2003;77:1361 – 1367.
  103. Misra M, McLaughlin D, Donahoe P, Lee MM. The role of Mullerian Inhibiting Substance in the Evaluation of Phenotypic Female Patients with Mild Degrees of Virilization. J Clin Endocrinol Metab. 2003;88:787-92.
  104. Soyka L, Misra M, Frenchman A, Miller, KK, Grinspoon S, Schoenfeld D, Klibanski A. Abnormal Bone Mineral Accrual in Adolescent Girls with Anorexia Nervosa. J Clin Endocrinol Metab. 2002;87:4177-85.
  105. Misra M, McLaughlin D, Donahoe P, Lee MM. Measurement of MIS Facilitates Management of Boys with Microphallus and Cryptorchidism. J Clin Endocrinol Metab. 2002;87:3598-3602.
  106. Misra M, Vavre S, Sharda MH. A Comparative Study of Intracervical PGE2 Gel and Intravenous Oxytocin in Induction of Labor before Term. Singapore J Obstet Gynecol. 1995;26:37-40.
  107. Misra M, Sharda MH, Mishra S. Epidemiology of LBW in an Industrial Hospital in India. J Trop Pediatr. 1995;41:001-2. PMID:8606450
  108. Misra M, Vavre S. Labor Induction with Intracervical PGE2 Gel and Intravenous Oxytocin in Women with a Very Unfavorable Cervix. Aust NZ J Obstet Gynecol. 1994;34:511-6.
  109. Misra M, Matah M, Gupta RM. Cell Mediated and Humoral Immunity in Abortions. Antiseptic. 1994;91:454-7.
  110. Misra M, Matah, M, Gupta RM. Immunology of Primary and Secondary Aborters. Singapore J Obstet Gynecol. 1993;24:112-6.

Reviews, chapters, monographs and editorials

  1. Srinivasan S, Misra M. Hyperthyroidism. Pediatrics in Review. In Press.
  2. Ackerman KE, Misra M. Neuroendocrine Abnormalities in Female Athletes. In: “Female Athlete Triad: A Clinical Guide”, Eds.: Gordon CM and LeBoff M. Springer Science + Business Media 2014. p85-109.
  3. Misra M, Klibanski A. Anorexia Nervosa and Bone. J Endocrinol 2014; 221(3):R163-R176. PMCID:PMC4047520
  4. Misra M, Klibanski A. Eating Disorders and their Effects on Bone Health. In: “Nutrition and Bone Health”, 2nd Edition, Eds.: Holick MF and Jerri Nieves, Totowa, (NJ): The Humana Press, Inc 2014. In Press
  5. Cuttler L, Misra M, Koontz M. Normal and Abnormal Growth. In ‘Endocrinology’ 7th Edition. Eds. Jameson JL and DeGroot LJ. Saunders Elsevier, Philadelphia PA. In Press.
  6. 6.     Misra M. Menstrual Health in the Female Athlete. In ‘Handbook of Sports Medicine and Science, The Female Athlete’. Ed. Mountjoy ML. Wiley Blackwell. p67-75.
  7. Misra M, Klibanski A. Endocrine Consequences of Anorexia Nervosa. The Lancet Diabetes and Endocrinology 2014;2(7):581-92. PMCID: PMC4133106
  8. Singhal V, Misra M, Klibanski A. Endocrinology of Anorexia Nervosa in Young People - Recent insights. Curr Opinion Endocrinol Diabetes. 2014;21(1):64-70.
  9. Misra M. Neuroendocrine Mechanisms in Athletes. In "Clinical Neuroendocrinology". Handbook Clin Neurol. 2014;124:373-86.
  10. Ackerman KE, Misra M. Nutrition in Sports Medicine. Nutrition in Pediatrics. 5th Edition. Eds. Duggan CP, Watkins JB, Koletzko B and Walker WA. 2013. In Press.
  11. Misra M, Klibanski A. Anorexia Nervosa, Obesity and Bone Metabolism. Pediatr Endocr Rev 2013;11(1):21-33
  12. Katzman DK, Misra M. Bone Health in Adolescent Females with Anorexia Nervosa: What’s a Clinician to do? Int J Eat Disord 2013; 46(5):456-60.
  13. Savgan-Gurol E, Misra M. Eating disorders in adolescence and their effect on ovarian function. In ‘PCOS in Adolescence’. Eds: Livadas and Diamanti-Kandarakis. Research Signpost 2012 In press.
  14. Misra M. Effects of Hypogonadism on Bone Metabolism in Adolescent and Young Adult Women. Nature Reviews Endocrinology 2012;8(7):395-404PMID: 22271187
  15. Balhara B, Misra M, Levitsky LL.  Recombinant human IGF-1 (Insulin-like Growth Factor) Therapy: Where do we stand today? For special supplement on ‘Growth Hormone’. Ind J Pediatr 2012;79(2):244-9. PMID: 22090255
  16. Valassi E, Biller BMK, Klibanski A, Misra M.  Adipokines and Cardiovascular Risk in Cushing’s Syndrome. Neuroendocrinology 2012;95(3):187-206PMID:22057123
  17. Misra M, Klibanski A. Bone Health in Anorexia Nervosa. Curr Opin Endocrinol Diabetes 2011; 18(6):376-82. PMID: 21897220
  18. Marino R, Misra M. Bone Health and Primary Ovarian Insufficiency. In Seminars in Reproductive Medicine. Larry Nelson. Ed. 2011; 29(4):317-27. PMID: 21969266
  19. Misra M. Vitamin D Deficiency in Children. In: UpToDate, Rose, BD (Ed), UpToDate, Waltham, MA, 2011
  20. Misra M, Klibanski A. Bone Metabolism in Adolescents with Anorexia Nervosa. J Endocrinol Invest 2011;34(4):324-32. Epub 2011 Feb 7. PMID: 21301203
  21. Katz M, Misra M. Delayed Puberty, Short Stature and Tall Stature. The MassGeneral Hospital for Children Adolescent Medicine Handbook. Ed. Goldstein MA. Springer New York Dordrecht Heidelberg London 2010; 147-154.
  22. Ackerman KE, Misra M. Bone health and the female athlete triad in adolescent athletes. The Physician and Sports Medicine 2011;39(1):131-41. PMID: 2137849.
  23. Misra M, Klibanski A. The Neuroendocrine Basis of Anorexia Nervosa. Neuroendocrinology 2011;93(2):65-73. PMID: 21228564
  24. Misra M, Cuttler L. Normal and Abnormal Growth. In ‘Endocrinology’ 6th Edition. Eds. Jameson JL and DeGroot LJ. Saunders Elsevier, Philadelphia PA 2010; 479-516.
  25. Russell M, Misra M. Influence of Ghrelin and Adipocytokines on Bone Mineral Density in Adolescent Female Athletes with Amenorrhea and Eumenorrheic Athletes. In ‘Physical Activity, Cytokines and Growth Mediators in Childhood and Adolescence’ Eds. Hills A, Jürimäe J and Jürimäe T. Med Sport Sci. 2010;55:103-13. PMID: 20956863
  26. Jacobson-Dickman E, Misra M. Skeletal Abnormalities in Anorexia Nervosa. IBMS BoneKey 2010;7:63-83.
  27. Misra M, Klibanski A. Neuroendocrine Consequences of Anorexia Nervosa in Adolescents. Endocr Dev. 2010;17:197-214. PMID: 19955768
  28. Nguyen V, Misra M. Transitioning of children with GH deficiency to adult dosing: Changes in body composition. Pituitary 2009;12(2):125-135.
  29. Levitsky LL, Misra M, Boepple PA, Hoppin A. Adolescent Obesity and Bariatric Surgery. Curr Opin Endocrinol Diabetes Obes. 2009;16(1):37-44.
  30. Misra M. What is the best strategy to combat low bone density in functional hypothalamic amenorrhea? Practice Point. Nature Clin Prac Endocrinol Metab. 2008;4(10):542-3
  31. Misra M. Long-term Skeletal Effects of Eating Disorders with Onset in Adolescence. Annals NY Acad Sci 2008;1135(1):212-8
  32. Prabhakaran R. Misra M. Osteoporosis in Anorexia Nervosa. Future Rheumatology 2008; 3(3):281-296
  33. Misra M. Bone Density in the Adolescent Athlete. Rev Endocr Metab Disord 2008; 9(2):139-44
  34. Stanley T, Misra M. Polycystic Ovarian Syndrome in Obese Adolescents. Curr Opin Endocrinol Diabetes Obes. 2008;15(1):30-6.
  35. Stanley T, Prabhakaran R, Misra M. Pituitary Tumors in Children. Contemporary Endocrinology. Pituitary Tumors: Diagnosis and Management. Eds.: Swearingen B, Biller BMK. Humana Press Inc. Totowa, NJ 2008; p 411-444.
  36. Misra M, Singhal A, Campbell DE. Thyroid Storm. eMedicine from WebMD. (since 2006) Updated January 05, 2010. Available at: http://emedicine.medscape.com/article/925147-overview
  37. Misra M, Klibanski A. Anorexia Nervosa and Osteoporosis. Rev Endocr Metab Disord. 2006;7(1-2):91-9
  38. Levitsky LL, Misra M. Type 1 Diabetes. In: UpToDate, Rose, BD (Ed), UpToDate, Waltham, MA, 2006
  39. Jacobson-Dickman E, Misra M. Gonadal Disorders. Gellis and Kagan’s Current Pediatric Therapy 18th edition. Eds.: Burg FD, Ingelfinger JR, Polin RA and Gershon AA, W.B. Saunders Company, Philadelphia, PA 2006; 980-9.
  40. Prabhakaran R, Misra M. Disorders of Puberty. Gellis and Kagan’s Current Pediatric Therapy 18th edition. Eds.: Burg FD, Ingelfinger JR, Polin RA and Gershon AA, W.B. Saunders Company, Philadelphia, PA 2006; 341-6.
  41. Misra M. Growth Hormone Treatment: Transitioning Care from Adolescence to Adulthood. MGH Neuroendocrine Clinical Center Bulletin 2005:11(2); 6-9.
  42. Misra M, Papakostas GI, Klibanski A. Effects of psychiatric disorders and psychotropic medications on prolactin and bone metabolism. J Clin Psychiatry. 2004;65(12):1607-18; quiz 1590, 1760-1.
  43. Misra M., Lee MM. Intersex Disorders. In: Pediatric Endocrinology: The Requisites in Pediatrics, ed. Thomas Moshang, Jr., M.D. St. Louis (MO): Elsevier Mosby;2004. p. 103-24.
  44. Misra M, Klibanski A. Eating Disorders and their Effects on Bone Health. In: In “Nutrition and Bone Health”, eds.: Holick MF and Dawson-Hughes B. Totowa, (NJ): The Humana Press, Inc.;2004. p. 617-34.
  45. Misra M., Lee MM. Delayed Puberty. In: Pediatric Endocrinology: The Requisites in Pediatrics, ed. Thomas Moshang, Jr., M.D. St. Louis (MO): Elsevier Mosby;2004. p. 87-102.
  46. Lee MM, Misra M, Donahoe PK, MacLaughlin DT. MIS/AMH in the assessment of cryptorchidism and intersex conditions. Mol Cell Endocrinol. 2003;211(1-2):91-8.
  47. Misra M, Klibanski A. Evaluation and treatment of low bone density in anorexia nervosa. Nutr Clin Care. 2002;5(6):298-308.
  48. Misra M, Levitsky LL, Lee MM. Transient hyperthyroidism in an adolescent with hydatidiform mole. J Pediatr. 2002;140(3):362-6.
  49. Misra M, Lee MM. Gonadal Disorders. In: Gellis and Kagan’s Current Pediatric Therapy Eds.: Burg FD, Ingelfinger JR, Polin RA and Gershon AA. Philadelphia (PA): W.B. Saunders Company;2002. p. 698-704.
  50. Misra M, Park-Bennett S. Disorders of Puberty. In: Gellis and Kagan’s Current Pediatric Therapy Eds.: Burg FD, Ingelfinger JR, Polin RA and Gershon AA. Philadelphia (PA): W.B. Saunders Company;2002. p. 706-10.

Clinical Guidelines and Reports

  1.  DeSouza MJ, Nattiv A, Joy E, Misra M, Williams NI, Mallinson RJ, Gibbs JC, Olmsted M, Goolsby M, Matheson G Expert Panel.  2014 Female Athlete Triad Coalition Consensus Statement on Treatment and Return to Play of the Female Athlete Triad: 1st International Conference held in San Francisco, California, May 2012 and 2nd International Conference held in Indianapolis, Indiana, May 2013. Br J Sports Med 2014; 48:289-308.
  2. Geller D, Pacaud D, Gordon CM, Misra M on behalf of the Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society. State of the Art Review: Emerging Therapies: The Use of Insulin Sensitizers in the Treatment of Adolescents with Polycystic Ovary Syndrome (PCOS). Int J Pediatr Endocrinol 2011;2011:9. PMID: 21899727
  3. Misra M, Pacaud D, Petryk A, Collett-Solberg P, Kappy M, on behalf of the Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society. Vitamin D Deficiency in Children and its Management: Review of Current Knowledge and Recommendations. Pediatrics 2008; 122: 398-417.  PMID:18676559
  4. Collett-Solberg P, Misra M on behalf of the Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society. The role of rhIGF-I in treating children with short stature. J Clin Endocrinol Metab. 2008;93(1):10-8. PMID:18165284

Pediatric Endocrine-Neuroendocrine-Sports Endocrine Research

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Phone: 617-724-5602
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617-643-0267
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Madhusmita Misra, MD
Director, MGH Pediatric Endocrine-Neuroendocrine-Sports Endocrine Research Lab
617-724-5602
mmisra@mgh.harvard.edu

For more information, please visit the Pediatric Neuroendocrine website.

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