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DMG can be obtained from digestion of certain foods such as beans, liver and cereals, and itselfis formed naturally in the body when a carbon-containing (methyl) group from trimethylglycine(TMG) is transferred to a molecule called homocysteine to form another substance, methionine.This reaction allows methyl groups to be available for “methylation” pathways that eventually helpmaintain cell membranes, facilitate growth and turn genes on and off, including those fordetoxification. Supplying extra DMG, however, does not directly influence “methylation pathways”.
The only double-blind placebo-controlled study of DMG using the high doses suggested by theAutism Research Institute was published in 2001 and showed no effect1.
The diagram below illustrates the formation of DMG from TMG. TMG donates a methyl group tohomocysteine, forming methionine. BHMT = betaine homocysteine methyltransferase (anenzyme)
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