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Glutathione is a sulfur-containing molecule composed of three amino acids, or building blocks of proteins: cysteine, glycine, and glutamic acid. It is a naturally-occurring molecule within cells that participates in the liver’s detoxification of many compounds, such as products from cigarette smoke, alcohol, and overdoses of aspirin and acetaminophen (Tylenol). Glutathione is part of a system of enzymes within all cells that reduce oxidative damage, such as that due to radiation, and it is involved in production of fatty acids1. It also facilitates the development and function of a variety of immune cells2.
Glutathione was first proposed in autism when signs of oxidative stress in the children’s peripheral blood were documented3, 4. Glutathione also “donates” sulfur groups in chemical reactions through its cysteine component, and was suggested for use in autism due to inferred deficiency in sulfur availability4.
Glutathione is not well absorbed when taken by mouth, and oral doses do not raise blood or tissue levels of glutathione. The fragile structure of glutathione cannot survive the gastrointestinal tract. When it is broken down, glutathione releases its component amino acids, two of which are excitatory (glutamate and cysteine) in the nervous system.
The body’s cells must generate their own intracellular glutathione for it to be effective over the long term, and glutathione must be in its reduced form to be active within cells. The unreduced form is not metabolically active. Manufacturers do not indicate if their product is reduced. Reduced glutathione is also very expensive compared to the unreduced form.
There are published reports of intravenous glutathione used for protection from adverse reactions from chemotherapy during treatment for cancer5, mild symptomatic improvements in Parkinson’s Disease6, and some relief of leg pain in patients with cardiovascular disease7. All of these studies were done in normally developed adults but none involved children with developmental disorders. There have been no clinical trials of oral or intravenous glutathione supplementation in children with autism that measured core symptoms of autism.
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