Treatment Programs

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Pediatric Neurogastroenterology Program

The Pediatric Neurogastroenterology Program at MassGeneral Hospital for Children provides a multidisciplinary team approach aimed at restoring nutritional status and improving bowel function in children with a variety of congenital or acquired intestinal problems.

Meet the Team

Medical/Surgical Staff

  • Allan M. Goldstein, MD
           Chief, Pediatric Surgery
           Co-Director, Pediatric Neurogastroenterology Program

Child Psychiatrist

Child Nutritionist

A Comprehensive Care Program

The Pediatric Neurogastroenterology Program at MassGeneral Hospital for Children (MGHfC) is designed to restore nutritional status and improve bowel function in children with a variety of chronic intestinal problems, including dysmotility, malabsorption and short bowel syndrome. Our goal is to provide a multidisciplinary approach that offers you and your child a wide range of expertise in the evaluation and treatment of children with severe intestinal disorders including:

  •     Hirschsprung’s disease
  •     Chronic intestinal pseudo-obstruction
  •     Short bowel syndrome
  •     Motility disorders
  •     Necrotizing enterocolitis
  •     Intestinal neuronal dysplasia
  •     Intestinal failure
  •     Radiation enteritis
  •     Gastroschisis
  •     Intestinal atresia
  •     Anorectal malformations

Our Multidisciplinary Team

Each child will be evaluated and cared for by a team of experts, including pediatric surgeons, gastroenterologists, nutritionists and nurses. Child psychiatrists, child life specialists and social workers are also readily available to assist in the care of these young patients. In collaboration with the Pediatric Gastrointestinal Motility Center at MGHfC, we use state-of-the-art equipment to examine the motility of the intestinal tract. Our team works closely with pathologists and radiologists who are experts in these complex conditions.

Jaime Belkind-Gerson, MD, examines an MGHfC patient.

Jaime Belkind-Gerson, MD, examines an MGHfC patient.

Cutting-Edge Research

Members of the Neurogastroenterology Program are actively involved in leading scientific research to understand better the causes of intestinal failure.

Our basic science research program aims to understand the development of the enteric nervous system and how abnormalities of nerve cell development in the intestine lead to functional disorders of the intestine, including Hirschsprung’s disease, pseudo-obstruction and abnormal intestinal barrier function. We are also currently studying the potential of isolating and transplanting neuronal stem cells into the intestine for the treatment of intestinal neuropathies such as Hirschsprung’s disease.

We also perform clinical research studies to understand the natural history and treatment outcomes of motility disorders, including gastroparesis, intestinal pseudo-obstruction and intractable constipation.

Members of the Neurogastrointestinal Program are actively involved in leading scientific research to understand better the causes of intestinal failure.

  • Our basic science research program aims to understand the development of the enteric nervous system and how abnormalities of nerve cell development in the intestine lead to various types of intestinal dysmotility, including Hirschsprung’s disease and severe constipation.
  • We are developing methods to transplant stem cells in order to replace missing or damaged nerve cells in the intestine.
  • Using metabolite profiling we are working to identify novel serum biomarkers associated with colonic contractility and constipation in children.
  • We are exploring novel minimally invasive technologies that will enable us to use colonoscopy and laparoscopy to visualize nerve cells in the intestine without the need for rectal or colonic biopsies.
  • Using a genetic mouse model, we are studying the causes of Hirschsprung’s-associated enterocolitis in order to develop methods to prevent this serious condition.

Hirschsprung Disease: exploring its causes, consequences, and novel treatments

Dr. Allan Goldstein researches the development of the enteric nervous system, including the causes of distal aganglionosis, causes and possible treatments of Hirschsprung-associated enterocolitis (HAEC), and neuronal cell transplantation, a novel treatment approach for Hirschsprung disease.

Frontiers in Pediatrics Gastroenterology, Hepatology & Nutrition 2013

This course is designed to meet one or more of the following Accreditation Council of Graduate Medical Education competencies: Patient care; Medical knowledge; Practice-based learning and improvement; Interpersonal and communication skills; Professionalism; Systems-based practice

REACH Symposium- Research, Education, and Awareness for Children with Hirschsprung's disease

The REACH Symposium (Research, Education, and Awareness for Children with Hirschsprung's disease) is a multidisciplinary conference highlighting important and up-to-date clinical and scientific topics in Hirschsprung's disease.

What is Hirschsprung’s Disease

Learn more about Dr. Allan Goldstein’s mission to find a cure for this rare colon disease effecting newborns.

MGHfC Pediatric Neurogastroenterology Program

Warren Building
11th Floor
55 Fruit Street
Boston, MA 02114

Phone: 617-726-0270
Fax: 617-726-2167

Public Transportation Access: yes
Disabled Access: yes

To schedule an appointment with a MassGeneral for Children pediatric specialist, please call 888-644-3248 or complete our online appointment form to request an appointment.

Physicians may call 888-644-3211 or use the online referral form and the Access & New Appointment Center will call your patient within 1 business day.

Next Steps:

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Make an appointment

Contact MassGeneral Hospital for Children to schedule an appointment with one of our specialists.

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Team approach

At MassGeneral Hospital for Children, members of the patient’s care team work together to provide coordinated, multidisciplinary treatment.

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Partners HealthCare Patient Gateway

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