Immunology & Inflammatory Diseases

View recent publications from investigators of the Center for Immunology and Inflammatory Diseases

Common genetic variants modulate pathogen-sensing responses in human dendritic cells

Lee MN, Ye C, Villani A-C, Raj T, Li W, Eisenhaure TM, Imboywa SH, Chipendo PI, Ran FA, Slowikowski K, Ward LC, Raddassi K, McCabe C, Lee MH, Frohlich IY, Hafler DA, Kellis M, Raychaudhuri S, Zhang F, Stranger BE, Benoist CO, DeJager PL, Regev A, Hacohen N. Science 2014; 343: 1246980.

Identification of human CCR8 as a CCL18 receptor

Islam SA, Ling MF, Leung J, Shreffler WG, Luster AD. Journal of Experimental Medicine 2013; 210; 1889-1898.

The microglial sensome revealed by direct RNA sequencing

Hickman SE, Kingery ND, Ohsumi TK, Borowsky ML, Wang L-C, Means TK, El Khoury J. Nature Neuroscience 2013; 16: 1896-1905.

The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity

Ramirez-Ortiz ZG, Pendergraft III WF, Prasad A, Byrne MH, Iram T, Blanchette CJ, Luster AD, Hacohen H, El Khoury J, Means TK. Nature Immunology 2013; 14: 917-926.

Dedifferentiation of committed epithelial cells into stem cells in vivo

Tata PR, Mou H, Pardo-Saganta A, Zhao R, Prabhu M, Law BM, Vinarsky V, Cho JL, Breton S, Sahay A, Medoff BD, Rajagopal J. Nature 2013; 503; 218-223.

CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation

Groom JR, Richmond J, Murooka TT, Sorensen EW, Sung JH, Bankert K, von Andrian UH, Moon JJ, Mempel TR, Luster AD. Immunity 2012; 37: 1091-1103.

A novel human autoantigen, endothelial cell growth factor, is a target of T and B cell responses in patients with Lyme disease

Drouin EE, Seward RJ, Strle K, McHugh G, Katchar K, Londono D, Yao C, Costello CE, Steere AC. Arthritis & Rheumatism 2013; 65: 186-196.

Lung dendritic cells imprint T cell homing and promote lung immunity through the chemokine receptor CCR4

Mikhak Z, Strassner JP, Luster AD. Journal of Experimental Medicine 2013; 210: 1855-1869.

LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation

Sakai N, Chun J, Duffield JS, Wada T, Luster AD, Tager AM. The FASEB Journal 2013; 27: 1830-1846.

PD-1 blockade in chronically HIV-1 infected humanized mice suppressess viral loads

Seung E, Dudek TE, Allen TM, Freeman GJ, Luster AD, Tager AM. PlosOne 2013; 8: e77780.

Clinical correlations with Porphyromonas gingivalis antibody responses in patients with early rheumatoid arthritis

Arvikar SL, Collier DS, Fisher MC, Unizony S, Cohen GL, McHugh G, Kawai T, Strle K, Steere AC. Arthritis Research & Therapy 2013; 15: R109.

Compartmentalized chemokine-dependent regulatory T-cell inhibition of allergic pulmonary inflammation

Afshar R, Strassner JP, Seung E, Causton B, Cho JL, Harris RS, Hamilos DL, Medoff BD, Luster AD. Journal of Allergy and Clinical Immunology 2013; 131: 1644-1652.

Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction

Bauer CA, Kim EY, Marangoni F, Carrizosa E, Claudio NM, Mempel TR. Journal of Clinical Investigation 2014; 124: 2425-2440.

Dysregulation of CD4+CD25high T cells in the synovial fluid of patients with antibiotic-refractory Lyme arthritis

Vudattu NK, Strle K, Steere AC, Drouin EE. Arthritis & Rheumatism 2013; 65: 1643-1653.

Evidence of pathway-specific basophil anergy induced by peanut oral immunotherapy in peanut-allergic children

Thyagarajan A, Jones SM, Calatroni A, Pons L, Kulis M, Woo CS, Kamalakannan M, Vickery BP, Scurlock AM, Burks AW, Shreffler WG. Clinical Experimental Allergy 2012; 42: 1197-1205.

Scara1 deficiency impairs clearance of soluble amyloid-B by mononuclear phagocytes and accelerates Alzheimer's-like disease progression

Frenkel D, Wilkinson K, Zhao L, Hickman SE, Means TK, Puckett L, Farfara D, Kingery ND, Weiner HL, El Khoury J. Nature Communications 2013: 4: 2030.

Chemokines and chemokine receptors: positioning cells for host defense and immunity

Griffith JW, Sokol CL, Luster AD. Annual Reviews of Immunology 2014; 32: 659-702.