Principal Investigator, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital
Assistant Immunologist, Massachusetts General Hospital
Assistant Professor of Medicine, Harvard Medical School
Associate Member, MGH Center for Systems Biology
Associate Investigator, MGH Center for the Study of Inflammatory Bowel Disease
T lymphocytes are part of the adaptive immune system. They are powerful players in the defense against infection and can be effective against tumors, but they are also involved in autoimmune responses, leading to diseases such as diabetes, arthritis, or multiple sclerosis.
T cell responses arise from clonal expansion of a small number of naïve precursors through antigenic priming by dendritic cells in secondary lymphoid organs, such as lymph nodes and the spleen. Once these naïve T cells have differentiated to effector T cells, they migrate to the blood, from where they are recruited to peripheral tissues to combat disease.
To prevent attacks on healthy tissues, the execution of T cell effector functions is tightly linked to the recognition of cognate antigen. In addition, immune responses are regulated through diverse inhibitory and stimulatory signals that T cells encounter in peripheral tissues. Dr. Mempel's lab is seeking to understand how the function of T cells is regulated through their interaction with other cells, structural tissue components and soluble mediators that they encounter in tissues. Their main approach to this end is direct dynamic in vivo visualization of immune processes at cellular and subcellular resolution in living mice, using multiphoton intravital microscopy.
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