Robert E. Gerszten, MD

The Gerszten Laboratory at Massachusetts General Hospital investigates the molecular basis of injury responses in cardiovascular disease.


Principal Investigator, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital

Director of the Clinical and Translational Research Program, MGH Heart Center

Associate Professor of Medicine, Harvard Medical School

Senior Associate, Broad Institute of Harvard and MIT

Dr. Gerszten’s research efforts focus on understanding the molecular basis of injury responses in cardiovascular disease. His laboratory has incorporated emerging proteomics and metabolomics technologies to help identify novel signals derived from leukocytes, endothelial cells, or from the myocardium. In ongoing translational studies, his group applies these same methodologies directly to samples from well-phenotyped human cohorts to identify candidate biomarkers, returning again to the bench to define functional roles. The research incorporates basic molecular and cell biology, chemistry and mass spectrometry, bioinformatics, all with a foundation in clinical medicine. The overall goal is to identify new metabolites and proteins that mark cardiovascular disease activity, shed insight into disease progression, and provide targets for therapeutic intervention.

Group Members

Principal Investigator:

  • Robert E. Gerszten, MD

Postdoctoral Fellows:

  • Marita Barth, PhD
  • Greg Lewis, MD
  • Eugene Rhee, MD

Research Scientists:

  • Fjori Kristo, MD
  • Dongxiao Shen, PhD
  • Xu Shi, PhD


  • Alex Palma
  • Melinda Palma

Clinical Study Coordinators:

  • Maryann Martinovic
  • Laurie Farrell

Research Projects

  • Role of chemokines and bioactive lipids in atherosclerosis and aneurysm formation in murine and cell-based models
  • Novel protein and metabolic biomarkers of atherosclerosis
  • Novel protein and metabolic biomarkers of diabetes and its complications
  • Proteomics approaches to monocyte activation
  • Defining genetic determinants of metabolism integrating human genome wide scanning, metabolomic profiling and recombinant inbred murine strains



Contact Us

Gerszten Laboratory

CNY 149-8

149 13th Street Charlestown, MA 02129
  • Near Public Transit
  • Handicapped Accessible
  • Phone: 617-724-8322
  • Fax: 617-726-5651
  • Email Us


  • Monday-Friday, 8:30 am-5:00 pm

Administrative Assistant - Colleen Squires

Phone: 617-726-1527

Laboratory Manager - Sumita Sinha, PhD

Phone: 617-726-0725

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