Massachusetts General Hospital

Chief, Division of Rheumatology, Allergy and Immunology
Director, Center for Immunology and Inflammatory Diseases
Persis, Cyrus and Marlow B. Harrison Professor of Medicine, Harvard Medical School

 

The Luster Laboratory focuses on understanding the role of chemokines and lipid chemoattractants and their receptors in controlling the trafficking of leukocytes in vivo. Gene-targeted and transgenic mouse strains have been developed to study the role of chemokines and chemoattractant receptors in the development and delivery of organ-specific innate and adaptive immune and inflammatory responses in mouse models of inflammatory, autoimmune, allergic and infectious diseases. System biology approaches are being utilized to understand how multiple chemoattractant pathways are integrated in vivo for the fine control of leukocyte trafficking. In vivo multiphoton microscopy is being utilized to interrogate the function of chemokines in controlling the migratory and interactive behavior of T cells and dendritic cells in lymph nodes and peripheral tissue. We also study the regulation of chemokine production in vivo since this is a critical determinant of their role in a given biological response. We have a particular interest in the role of innate immune receptors, such as toll-like receptors, in regulating chemokine production in vivo. We are also interested in structure-function relationships of chemokines and their receptors as well as the molecular mechanism of chemokine signal transduction, as these are important questions relevant to chemotaxis and immune cell trafficking in health and disease. Finally, chemokines and chemoattractant receptors are interrogated in human diseases to determine chemokine systems relevant for disease pathogenesis.

Principal Investigator:

• Andrew D. Luster, MD, PhD

Junior Faculty:

• Shannon Bromley, PhD
• Sabina Islam, MD
• Nancy Kim, MD
• Zamaneh Mikhak, MD

Postdoctoral Fellows:

• Roshi Afshar, PhD
• Maud Deruaz, PhD
• Lucas Faustino, PhD
• Jason Griffith, MD, PhD
• Morris Ling, MD
• Norihiko Sakai, MD, PhD
• Caroline Sokol, PhD
• Elizabeth Sorensen, PhD

Senior Laboratory Manager:

• Carol P. Leary, BA

Technicians:

• Elena Alekseeva, MS

Luster Lab Alumni

If you are interested in applying for a postdoctoral position, or are a Harvard PhD student interested in a laboratory rotation, please e-mail your CV (for student and postdoctoral) and reference letters (for postdoctoral) to: aluster@mgh.harvard.edu.

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Luster Laboratory

Phone: 617-726-5710
Fax: 617-726-5651
Email: aluster@mgh.harvard.edu
Hours: Mon-Fri 8:30am-5pm

Public Transportation Access: yes
Disabled Access: yes

Senior Executive Assistant - Diane Qualters

Tel: 617-724-6147

E-mail: dqualters@partners.org

Senior Laboratory Manager - Carol Leary

Tel: 617-724-4992

E-mail: cleary1@partners.org