Immunology & Inflammatory Diseases

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Andrew D. Luster, MD, PhD

The Luster Laboratory investigates chemokines, lipid chemoattractants and their receptors in normal physiology and disease.

    Chief, Division of Rheumatology, Allergy and Immunology
    Director, Center for Immunology and Inflammatory Diseases

    Persis, Cyrus and Marlow B. Harrison Professor of Medicine, Harvard Medical School

     

    The Luster Laboratory focuses on understanding the role of chemokines and lipid chemoattractants and their receptors in controlling the trafficking of leukocytes in vivo. Gene-targeted and transgenic mouse strains have been developed to study the role of chemokines and chemoattractant receptors in the development and delivery of organ-specific innate and adaptive immune and inflammatory responses in mouse models of inflammatory, autoimmune, allergic and infectious diseases. System biology approaches are being utilized to understand how multiple chemoattractant pathways are integrated in vivo for the fine control of leukocyte trafficking. In vivo multiphoton microscopy is being utilized to interrogate the function of chemokines in controlling the migratory and interactive behavior of T cells and dendritic cells in lymph nodes and peripheral tissue. We also study the regulation of chemokine production in vivo since this is a critical determinant of their role in a given biological response. We have a particular interest in the role of innate immune receptors, such as toll-like receptors, in regulating chemokine production in vivo. We are also interested in structure-function relationships of chemokines and their receptors as well as the molecular mechanism of chemokine signal transduction, as these are important questions relevant to chemotaxis and immune cell trafficking in health and disease. Finally, chemokines and chemoattractant receptors are interrogated in human diseases to determine chemokine systems relevant for disease pathogenesis.

Principal Investigator:

  • Andrew D. Luster, MD, PhD

Junior Faculty:

  • Shannon Bromley, PhD
  • Sabina Islam, MD
  • Nancy Kim, MD
  • Zamaneh Mikhak, MD

Postdoctoral Fellows:

  • Roshi Afshar, PhD
  • Maud Deruaz, PhD
  • Lucas Faustino, PhD
  • Jason Griffith, MD, PhD
  • Morris Ling, MD
  • Norihiko Sakai, MD, PhD
  • Caroline Sokol, PhD
  • Elizabeth Sorensen, PhD

Senior Laboratory Manager:

  • Carol P. Leary, BA

Technicians:

  • Elena Alekseeva, MS

Luster Lab Alumni

  • Chemokines and lipid mediators in the regulation of T cell and dendritic cell migratory behavior in the lymph node and peripheral tissue
  • Chemokines and lipid mediators in the regulation of T cell and eosinophil trafficking and function in allergic inflammation, such as asthma and atopic dermatitis
  • Chemokines and lipid mediators in the regulation of leukocyte trafficking into the joint in rheumatoid arthritis
  • HIV immune pathogenesis and vaccine development in humanized mice
  • Chemokines and lipid mediators in the regulation of fibrosis
  • Structure function studies of chemokines
  • Biochemical and genetic dissection of chemokine receptor signal transduction
  • Toll-like receptor (TLR) regulation of chemokine and chemokine receptor expression
  • TLR function in autoimmune diseases, such as systemic lupus erythematosus
  • Chemokines and lipid mediators in the regulation of transplantation rejection
  • Chemokines and lipid mediators in atherosclerosis
  • Chemokines in microglial function and trafficking in Alzheimer's Disease
  • If you are interested in applying for a postdoctoral position, or are a Harvard PhD student interested in a laboratory rotation, please e-mail your CV (for student and postdoctoral) and reference letters (for postdoctoral) to: aluster@mgh.harvard.edu.

    Luster Laboratory

    CNY 149-8
    149 13th Street
    Charlestown, MA 02129

    Phone: 617-726-5710
    Fax: 617-726-5651
    Email: aluster@mgh.harvard.edu
    Hours: Mon-Fri 8:30am-5pm

    Public Transportation Access: yes
    Disabled Access: yes

    Senior Executive Assistant - Diane Qualters

    Tel: 617-724-6147

    E-mail: dqualters@partners.org

     

    Senior Laboratory Manager - Carol Leary

    Tel: 617-724-4992

    E-mail: cleary1@partners.org