Photo of Andrew D. Luster

Andrew D. Luster, MD, PhD

The Luster Laboratory at Massachusetts General Hospital investigates chemokines, lipid chemoattractants and their receptors in normal physiology and disease.

Overview

Chief, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital
Director, Center for Immunology and Inflammatory Diseases
, Massachusetts General Hospital
E. Alexandria and Michael B. Altman Chair in Immunology, Massachusetts General Hospital
Persis, Cyrus and Marlow B. Harrison Professor of Medicine, Harvard Medical School

 

The Luster Laboratory focuses on understanding the role of chemokines and lipid chemoattractants and their receptors in controlling the trafficking of leukocytes in vivo. Gene-targeted and transgenic mouse strains have been developed to study the role of chemokines and chemoattractant receptors in the development and delivery of organ-specific innate and adaptive immune and inflammatory responses in mouse models of inflammatory, autoimmune, allergic and infectious diseases. System biology approaches are being utilized to understand how multiple chemoattractant pathways are integrated in vivo for the fine control of leukocyte trafficking. In vivo multiphoton microscopy is being utilized to interrogate the function of chemokines in controlling the migratory and interactive behavior of T cells and dendritic cells in lymph nodes and peripheral tissue. We also study the regulation of chemokine production in vivo since this is a critical determinant of their role in a given biological response. We have a particular interest in the role of innate immune receptors, such as toll-like receptors, in regulating chemokine production in vivo. We are also interested in structure-function relationships of chemokines and their receptors as well as the molecular mechanism of chemokine signal transduction, as these are important questions relevant to chemotaxis and immune cell trafficking in health and disease. Finally, chemokines and chemoattractant receptors are interrogated in human diseases to determine chemokine systems relevant for disease pathogenesis.

Group Members

Principal Investigator:

  • Andrew D. Luster, MD, PhD

Assistant Professors:

  • Shannon Bromley, PhD
  • Sabina Islam, MD
  • Ahmad Sedaghat, MD, PhD

Research Staff:

  • Ben Michael, MBChB, MRCP, PhD

Instructors:

  • Maud Deruaz, PhD
  • Jason Griffith, MD, PhD
  • Mo Ling, MD
  • Carrie Sokol, MD, PhD

Postdoctoral Fellows:

  • Melvyn Chow, PhD
  • Lucas Faustino, PhD
  • Chie Miyabe, MD, PhD
  • Yoshi Miyabe, MD, PhD
  • Aleksandra Ozga, PhD
  • Rod Rahimi, MD, PhD
  • Elizabeth Sorensen, PhD

Graduate Student:

  • Jeff Lian

Senior Laboratory Manager:

  • Carol P. Leary

Technicians:

  • Ryan Camire
  • Kyrillos Farag
  • Sophina Ji
  • Keshav Nepal

Luster Lab Alumni

Research Projects

  • Chemokines and lipid mediators in the regulation of immune cell trafficking necessary to generate innate and adaptive immune responses that mediate the host response to infectious, inflammatory, autoimmune and malignant diseases.
  • Chemokines and lipid mediators in immune checkpoint blockade immunotherapy of cancer.
  • In vivo imaging chemokine and lipid mediator function in disease.
  • Regulatory T cell function in allergic, autoimmune and infectious diseases.
  • Resident memory T cell formation and function in allergic, autoimmune and infectious diseases.
  • Allergen-specific effector and regulatory T cell responses in the pathogenesis of human allergic asthma.
  • HIV transmission and immune pathogens in humanized mice.

Research Positions

If you are interested in applying for a postdoctoral position, or are a Harvard PhD student interested in a laboratory rotation, please e-mail your CV (for student and postdoctoral) and reference letters (for postdoctoral) to:aluster@mgh.harvard.edu

Publications

Contact

Contact Us

Luster Laboratory

CNY 149-8

149 13th Street Charlestown, MA 02129
  • Near Public Transit
  • Accessible
  • Phone: 617-726-5710
  • Fax: 617-726-5651
  • Email Us

Senior Executive Assistant - Diane Qualters

Phone: 617-724-6147
Email

Senior Laboratory Manager - Carol Leary

Phone: 617-724-4992
Email

Back to Top