Photo of Robert Anthony

Robert Anthony, PhD

The Anthony Laboratory at Massachusetts General Hospital investigates the role and regulation of immunoglobulin glycosylation.

Overview

Principal Investigator, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital

Assistant Immunologist, Department of Medicine, Massachusetts General Hospital

Assistant Professor of Medicine, Harvard Medical School

 

Antibodies are the preeminent effector proteins of the immune system. The bimodal activity of antibodies allows simultaneous recognition of antigen (by the antigen-binding fragment, Fab) with high affinity, and recruitment and activation of leukocytes through interactions between the constant, crystallizable fragment (Fc) and Fc receptors (FcRs) expressed by innate immune cells. Studies have demonstrated that antibody glycosylation is an important regulator of Fc-FcR interactions. Our laboratory is particularly interested in the role and regulation of IgE and IgG glycosylation in health and disease.

Group Members

Principal Investigator:

  • Robert Anthony, PhD

Junior Faculty:

  • Michelle Conroy, MD

Postdoctoral Fellow:

  • Kai-Ting Chuang Shade, PhD

Research Associate:

  • Jose Pagan

Research Technician:

  • Maya Kitaoka

 

Research Projects

  • The role and regulation of IgE glycosylation in allergy.
  • The role and regulation of IgG glycosylation in homeostasis and disease.

Publications

Contact

Contact Us

Anthony Laboratory

CNY 149-8

149 13th Street Charlestown, MA 02129
  • Near Public Transit
  • Accessible
  • Phone: 617-724-4245
  • Fax: 617-726-5651
  • Email Us

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