Conditions & Treatments

Ataxia

Ataxia causes a failure of muscle control in the arms and legs which may result in a lack of balance, coordination and possibly a disturbance in gait.

Ataxia

What is ataxia?

Ataxia means without coordination.

People who are diagnosed with ataxia lose muscle control in their arms and legs, which may lead to a lack of balance, coordination, and possibly a disturbance in gait. Ataxia may affect the fingers, hands, arms, legs, body, speech, and even eye movements.

Ataxia is often used to describe the symptom of incoordination that may accompany infections, injuries, other diseases, and/or degenerative changes in the central nervous system. The symptom of ataxia can be caused by stroke, multiple sclerosis, tumors, alcoholism, peripheral neuropathy, metabolic disorders, and vitamin deficiencies. in these cases, treating the condition that caused ataxia my improve it.

While the term ataxia usually describes symptoms, it also describes a group of specific degenerative diseases of the central nervous system called the hereditary and sporadic ataxias. The remainder of this article discusses these disorders.

What causes ataxia?

Most disorders that result in ataxia are found to have degeneration, or atrophy, of the cells in the part of the brain called the cerebellum. The cerebellum is located at the back of the head. Its function is to coordinate voluntary muscle movements and to maintain posture, balance, and equilibrium.

Anatomy of the brain
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The spine can also be affected. The terms cerebellar degeneration and spinocerebellar degeneration may be used to refer to this type of damage to the nervous system. 

The various abnormal genes that cause ataxia do have something in common: they make abnormal proteins that affect nerve cells, primarily in the cerebellum and in the spinal cord. They may also affect other parts of the brain.

The affected nerve cells begin to function poorly and ultimately degenerate. As the disease progresses, muscles become less and less responsive to the commands of the brain. This causes balance and coordination to become a greater problem.

Types of ataxia

As discussed above, there are two types of ataxia:

  • Sporadic ataxias. Ataxias of this type usually begin in adulthood and have no known family history.

  • Hereditary ataxias. These ataxias are caused by a defect in a gene that is present from the start of a person's life and can be either dominantly inherited or recessively inherited. Recessive disorders commonly cause symptoms to begin in childhood rather than in adulthood.
    Genetic testing is now available. Friedreich's ataxia is recessively inherited and occurs in childhood, but can have an adult onset in up to one third of patients. Dominant ataxia often begins in the twenties or thirties or sometimes even later in life.
    Hereditary ataxias are degenerative disorders that may progress over a number of years. How severe the disability depends on the type of ataxia, the age of onset of symptoms, and other factors that are poorly understood.

What are common symptoms of ataxia?

Symptoms and time of onset may vary according to the type of ataxia. Each individual may experience symptoms differently.

Typically the most common are listed below:

  • Balance and coordination are affected first

  • Incoordination of hands, arms, and legs

  • Slurring of speech

  • Wide-based gait

  • Difficulty with writing and eating

  • Slow eye movements

The symptoms of ataxia may resemble other conditions or medical problems. Always consult your doctor for a diagnosis.

How is ataxia diagnosed?

In addition to a thorough medical history, family history, and complete neurological and physical examination, the following diagnostic procedures may be performed:

  • Laboratory tests (including blood and urine studies)

  • Magnetic resonance imaging (MRI). A diagnostic procedure that uses a combination of large magnets, radiofrequencies, and  a computer to produce detailed images of organs and structures within the body

  • Genetic testing. Tests performed to determine if a person has certain gene changes (mutations) or chromosome changes which are known to increase risk for certain inherited conditions

These diagnostic procedures may also be used to rule out other conditions that can cause ataxia to appear. Certain conditions can cause ataxia to appear suddenly, such as head trauma, stroke, brain hemorrhage, brain tumor, congenital abnormalities, infections, post exposure to certain drugs, and also following cardiac or respiratory arrests.

Some conditions can cause ataxia to appear gradually, such as hypothyroidism, deficiencies of certain vitamins such as B-12 or vitamin E, exposure to certain drugs, multiple sclerosis, syphilis, and other disorders.

Treatment for ataxia

At this time there is no cure for the hereditary ataxias. There is also no medication currently available which treats the specific symptom of ataxia.

If ataxia is due to a stroke, a low vitamin level, or exposure to a toxic drug or chemical, then treatment is aimed at treating those specific conditions.

The treatment for the incoordination or imbalance mostly involves the use of adaptive devices to allow the individual to maintain as much independence as possible. Such devices may include the use of a cane, crutches, walker, or wheelchair. Physical therapy, speech therapy, and medications to help symptoms, such as tremor, stiffness, depression, spasticity, and sleep disorders, may also be beneficial.

Research is being conducted on cerebellar and spinocerebellar degeneration, including work aimed at finding the cause(s) of ataxias and ways to treat, cure, and ultimately prevent them, according to the National Institute of Neurological Disorders and Stroke.

Treatment Programs


Massachusetts General Hospital understands that a variety of factors influence patients' health care decisions. That's just one reason why we're dedicated to ensuring patients understand their diagnosis and treatment options. Because a single option might not serve all patients, we offer a wide range of coordinated treatments and related services across the hospital. Patients should consult with their primary care doctor or other qualified health care provider for medical advice and diagnosis information.

Select a treatment program for more information:



Imaging

  • Pediatric Imaging
    The Pediatric Imaging Program at Massachusetts General Hospital Imaging specializes in ensuring the safety and comfort of child patients while providing the latest technology and the expertise of specialized pediatric radiologists.
  • Neuroendovascular Program
    Working as part of the Vascular Center, the interventional specialists of the Neuroendovascular Program perform minimally invasive, image-guided treatments for conditions including stroke and cerebral aneurysm. These same interventionalists also use minimally invasive techniques to treat non-vascular conditions including herniated disc and vertebral fractures. In addition, our specialty-trained radiologists use the latest imaging technologies to provide diagnostic exams for a full range of neurological conditions.
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  • Pediatric Speech, Language and Swallowing Disorders
    The Department of Speech, Language and Swallowing Disorders and Reading Disabilities at MassGeneral Hospital for Children diagnoses and treats children and adolescents with speech, language, reading and swallowing impairments and disorders.
  • Psychology Assessment Center
    The pediatric neuropsychology specialists at Massachusetts General Hospital’s Psychology Assessment Center provide neuropsychological assessments to aid in the diagnosis and treatment of neurological, medical, genetic and developmental disorders.
  • Pediatric Feeding Program
    The Pediatric Feeding Program at MassGeneral Hospital for Children diagnoses and treats feeding and swallowing disorders, or dysphagia, in infants, toddlers, children and adolescents.
Department of Neurology

  • Neuro-ophthalmology Service
    The Neuro-ophthalmology Service at Massachusetts General Hospital provides expert evaluation, diagnosis and treatment for patients who have vision problems with a neurologic basis.
  • Ataxia Unit
    The Massachusetts General Hospital Ataxia Unit provides expert diagnosis, treatment and education for patients with ataxia and other cerebellar disorders.
  • General Pediatric Neurology
    General Pediatric Neurology physicians diagnose and treat all neurological disorders in children, infants and adolescents.

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