Conditions & Treatments

Underactive Adrenal Glands / Addisons Disease

Addison's disease is the result of an underactive adrenal gland.

Adrenal Insufficiency/Addison's Disease

What is adrenal insufficiency?

Adrenal insufficiency is classified as primary or secondary. Primary adrenal insufficiency is known as Addison's disease. Addison's disease occurs when the adrenal glands are damaged and cannot produce enough of the hormone cortisol  (hydrocortisone), and often the hormone aldosterone. Secondary adrenal insufficiency occurs when the pituitary gland in the brain fails to produce enough adrenocorticotropin hormone (ACTH). This leads to lack of production of cortisol in the adrenal glands. 

The adrenal glands are located just above each kidney. Normally functioning adrenal glands work interactively with the hypothalamus and pituitary glands in the brain. The hypothalamus produces corticotropin releasing hormone, which stimulates the pituitary gland to produce ACTH. ACTH then stimulates the adrenal glands to produce cortisol and release it into the bloodstream. Cortisol is a steroid hormone that helps control the metabolism of fats, proteins, and carbohydrates. It also affects immune system functions and suppresses inflammatory reactions in the body.

The adrenal glands also produce aldosterone to help maintain blood pressure, water balance, and sodium and potassium balance. Addison's disease is considered rare. Onset of this disease may occur at any age. 

What causes Addison's disease?

Destruction of the adrenal glands due to an autoimmune response is the most common cause of the disease. Some cases of Addison's disease are caused by the actual destruction of the adrenal glands through cancer, infection, or other events. Other causes may include:

  • Fungal infections

  • Tuberculosis infection of the adrenal glands 

  • Inherited disorders of the endocrine glands 

What causes secondary adrenal insufficiency?

A lack of ACTH leads to secondary adrenal insufficiency. A common cause for this is suppression of ACTH through long-term use of steroids such as prednisone. Prednisone is often used to help patients with severe asthma, rheumatoid arthritis, and some other chronic conditions. Other causes include:

  • Pituitary gland tumors

  • Loss of blood flow to the pituitary 

  • Surgical removal or radiation treatment of the pituitary

  • Surgical removal of parts of the hypothalamus 

What are the symptoms of adrenal insufficiency/Addison's disease?

Mild symptoms of adrenal insufficiency/Addison's disease may only be apparent when the patient is under physical stress. The following are the most common symptoms. However, each individual may experience symptoms differently. Symptoms may include:

  • Weakness

  • Fatigue

  • Dizziness

  • Dark skin (Addison's disease only)

  • Bluish-black discoloration around the nipples, mouth, rectum, scrotum, or vagina (Addison's disease only)

  • Weight loss

  • Dehydration

  • Lack of appetite

  • Muscle aches

  • Nausea

  • Vomiting

  • Diarrhea

  • Low blood pressure

  • Low sugar levels (hypoglycemia)

  • In women, irregular or absent menstrual periods

If not treated, Addison's disease may lead to severe abdominal pain, extreme weakness, low blood pressure, kidney failure, and shock—especially when the patient is experiencing physical stress.

The symptoms of Addison's disease may resemble other conditions or medical problems. Always consult your doctor for a diagnosis.

How is Addison's disease diagnosed?

In addition to a complete medical history and medical examination, diagnostic procedures for Addison's disease may include:

  • Various blood and urine tests to measure adrenal hormone levels

  • Radiology tests including X-ray, ultrasound, CT (computed tomography) scan or MRI (magnetic resonance imaging)

How is adrenal insufficiency/Addison's disease treated?

Treatment consists of replacing or substituting the hormones that are not being produced by the adrenal glands. This includes cortisol and, in Addison's disease, aldosterone.

Since Addison's disease can be life threatening, treatment often begins with administration of corticosteroids. Corticosteroids, such as prednisone, may be taken orally or intravenously, depending on the patient's condition. Usually the patient has to continue taking the corticosteroid the rest of his or her life. Treatment may also include taking fludrocortisone, a drug that helps maintain normal levels of sodium and potassium in the body.

Treatment Programs

Massachusetts General Hospital understands that a variety of factors influence patients' health care decisions. That's just one reason why we're dedicated to ensuring patients understand their diagnosis and treatment options. Because a single option might not serve all patients, we offer a wide range of coordinated treatments and related services across the hospital. Patients should consult with their primary care doctor or other qualified health care provider for medical advice and diagnosis information.

Select a treatment program for more information:


  • Adult Medicine Imaging
    The Adult Medicine Imaging Program at Massachusetts General Hospital Imaging offers a wide range of diagnostic exams and minimally invasive, image-guided treatments, all provided using leading-edge equipment and interpreted by specialty-trained radiologists.
MassGeneral Hospital for Children

  • Pediatric Endocrine Program and Diabetes Center
    The Pediatric Endocrinology Program and Diabetes Center at MassGeneral Hospital for Children is an international referral center for the management of pediatric diabetes and endocrine disorders in children and adolescents.
Neuroendocrine Unit

  • Neuroendocrine & Pituitary Clinical Center
    The Neuroendocrine & Pituitary Clinical Center provides multidisciplinary care and specializes in the diagnosis, evaluation and treatment of pituitary tumors and disorders of the hypothalamus and pituitary.

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