Critical Care Center Events

Taylor Thompson, MD, will discuss the rationale for conducting a randomized, placebo-controlled trial of rhAPC within the approved indication (septic shock) and the implications this negative trial has for future clinical trials for sepsis.

Critical Care Grand Rounds: "The Prowess-Shock Trial: Results and Implications for Future Trials for Sepsis"

Date: 11/01/2012 - 11/01/2012
Time: 7:00 am - 8:00 am
Location: Simches Auditorium, Simches Building

Agenda:

Taylor Thompson, MD, will discuss the rationale for conducting a randomized, placebo-controlled trial of rhAPC within the approved indication (septic shock) and the implications this negative trial has for future clinical trials for sepsis.

Dr. Thompson is a Professor of Medicine at Harvard Medical School. He directs the Critical Care Translational Medicine Group in the Pulmonary and Critical Care Unit at Massachusetts General Hospital. For 21 years he directed the Medical Intensive Care Unit at Mass General, where he is recognized an outstanding clinician and educator.

Dr. Thompson has considerable experience in the conduct and monitoring of clinical trials, beginning with his work as the clinical scientist on the NHLBI-funded PIOPED study in the 1980s. For 18 years he has been the medical director of the National Heart, Blood and Lung-funded ARDS Clinical Coordinating Center. He has chaired or currently chairs a number of Data and Safety Monitoring Boards for the NHLBI (Scleroderma Lung Study, IPF Network, HIV Lung Study, GRAIL) and the Canadian Clinical Trials Group (OSCILLATE), and recently served as Co-PI on a major sepsis trial conducted by Eli Lilly (PROWESS-SHOCK; rhAPC for septic shock). He also serves on the steering committees of ongoing phase II trials, the Lung Injury Prevention Study with Aspirin (LIPS-A) study and EP-Vent (esophageal pressure guided PEEP titration for ARDS) study. He has published more than 140 peer-reviewed manuscripts.

B. Taylor Thompson MD
Medical Director, ARDS Network Coordinating Center
Massachusetts General Hospital, Boston MA
Professor of Medicine, Harvard Medical School
Phone: 617-726-2189
Fax: 617-726-9878


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