Core Personnel:

Cornelis Terhorst, PhD
Co-Director
cterhors@bidmc.harvard.edu
Hans-Christian Reinecker, MD
Co-Director
hans-christian_reinecker@hms.harvard.edu
Michael O'Keeffe
Research Technician
Pankaj Shah
Research Technician
Atul Bhan, MD
Consultant
Arlene Sharpe, MD, PhD
Consultant
Thorsten Mempel, MD, PhD
Consultant
Gregory Lauwers, MD
Consultant
Omer Yilmaz, MD, PhD
Consultant
 


Overview:

The Genetic Animal Models Core provides emerging genetic technology and model systems that enable transformative investigation into the impact of human genetic variants associated with IBD, including infantile and early-onset IBD. The Core provides services for investigations of in vivo function of IBD-associated genetic variants with the goals of identifying relevant pathways,defining microbiome-host interactions,gaining insight into systems that control intestinal inflammation, andunderstanding mechanisms of recovery from epithelial injury. Through project-focused consultations, educational programs including extensive training opportunities, open lab meetings and workshops, and direct experimental support (e.g., providing protocols and novel model systems), the Core serves a key role in facilitating access to state-of-the-art genome editing approaches and experimental systems for research programs that focus on digestive diseases.

The objectives of the Genetic Animal Models Core are as follows:

  1. Support investigations in mice aimed at elucidating the contribution of IBD-related genetic variants and related genes to the pathogenesis of IBD in humans
  2. Functional in vitro and in vivo imaging of cellular responses and migration in the mucosal and peripheral immune system
  3. Support sharing of model systems and tools to foster collaborations among CSIBD investigators

Available services:

  • Genome editing in ES cells
  • Tissue- and cell type-specific gene targeting
  • Model systems for IBD
  • Functional imaging
  • Mouse models of intestinal inflammation
  • Models of host defense

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