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Center for the Study of IBD
Human Genetics and Microbiome Core
To most efficiently serve the CSIBD community, the former standalone Genetics, Genomics and Molecular Biology Core has been integrated with microbiome research activities (formerly centered in the Clinical/Tissue Core) to form the CSIBD Human Genetics and Microbiome Core. The Core continues to bring a variety of cutting-edge techniques in genetics/genomics and computational resources, while expanding its activities toward fully integrating cutting-edge microbiome research services. This core provides current and emerging technologies, pursues robust performance at the highest quality standards, and is committed to drive development toward future needs. The services are broadly divided between training and education, access to tools for molecular biology and ‘omics data generation, and computational resources for data analysis. In addition to building and supporting a vibrant community around a common interest, the leadership’s involvement in large-scale research projects worldwide also results in early access to emerging results.
Consultation and training. Central to all services are formal and informal end-to-end consultations on experimental design, data generation and bioinformatics analysis. A variety of training opportunities and workshops are also offered to aid investigators in study design and data analysis from genetics-, genomics- and microbiome-based projects. For experimental work, full access to protocols and reagents for sophisticated molecular biology approaches is provided.
Bioinformatics support. A team of bioinformaticists and software developers with in-depth expertise are available within the Core to provide collaborative capacity for data analysis. For data from human genetics assays, this includes handling RNA-Seq, data from the Landmark 1000 platform, metabolomics assays, EST profiling and pathway reconstruction tools. For microbiome data, this includes analysis of taxonomic and functional composition using tools available from the www.huttenhower.org/biobakery platform, other microbiome analysis platforms and novel tools such as profiling of individual strains present in metagenomics data.
Tools for molecular biology:
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