CSIBD investigators organized by site affiliation and by research area
Massachusetts General Hospital |
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Beth Israel Deaconess Medical Center |
Harvard Medical School |
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Massachusetts Institute of Technology |
Tufts University |
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CELL SIGNALING AND REGULATION OF PROLIFERATION
- Joseph Avruch: Molecular biology of signaling in response to growth factors
- Sarah L. Booth: Impact of vitamin K on vascular health and immune function
- Lewis C. Cantley: Regulation NF-κB and CARD15-activated pathways and their alteration in Crohn’s disease; PI3Ks and cancer
- Daniel Chung: Tumor suppressor genes in IBD-associated cancer: characterization of cell signaling pathway and regulation by VEGF genes; angiogenesis in colon cancer
- Robert Gerszten: Role of chemokines in modulating inflammation
- Lee M. Kaplan: Genetic and genomics of obesity
- Sam Lee: The roles of tumor suppressor p53 and its downstream signaling in stress response
- Herbert Lin: Regulation of TGFβ and other growth factors expression: molecular mechanisms of injury
- Norbert Perrimon: The adult Drosophila gut: a model system for stem cell biopsy and intestinal cancer
- David Rhoads: Metabolic disorders of Type 2 diabetes and obesity
- Roy Soberman: Molecular organization of inflammation
- Vikas P. Sukhatme: Tumor immunology and metabolism
HOST CELL – MICROBE INTERACTION
- Frederick M. Ausubel: Innate immunity and host-pathogen interactions
- Stephen B. Calderwood: Mechanisms of toxin-mediated mucosal injury modeling of bacterial-host interactions
- Raymond Chung: Immune responses to HCV
- Marcia Goldberg: Mechanisms of bacterial (Shigella) invasion of intestinal epithelium: epithelial signaling in response to bacteria
- Deborah T. Hung: Genomic and chemical approaches to bacterial pathogenesis
- Ralph Isberg: Mechanisms of pathogenesis by bacteria
- Georg M. Lauer: Adaptive immune responses to viral pathogens
- Cammie Lesser: Molecular mechanisms of enteric bacterial pathogenesis
- Edward T. Ryan: Enteric bacterial factors inducing epithelial invasions: development of mucosal vaccines
- Jatin Vyas: Dendritic cell pathogen responses in immunity
- Gerald N. Wogan: Role of NO and ROS in colitis and cancer
- Mei X. Wu: Role of IEX1 and Gαi2 in inflammatory bowel disease
INNATE AND ADAPTIVE IMMUNITY
- Frederick W. Alt: Genomic instability and B lymphocyte development
- Amin Arnaout: Neutrophil-endothelial interactions; role of CD11/18
- Shannon Bromley: Visualization of CCR4-directed Treg control of IBD
- Joseph El Khoury: Regulation of macrophage functions by scavenger receptors
- Christine Kocks: Phagosome assembly and developmental immunology
- Andrew D. Luster: Chemokine receptors and mechanisms of chemokine action in lymphocyte recruitment and differentiation in IBD
- Terry K. Means: Molecular and cellular mechanisms of inflammation and host defense
- Benjamin D. Medoff: Carma proteins and NFΚB activation
- Thorsten Mempel: Controls of T cell effector function
- Aylwin Ng: Integrative systems biology of microbial sensing, autophagy, innate immune regulation and programming
- Jin Mo Park: Innate immune function of p38 MAP kinase
- Shiv Pillai: Regulation of B cell development in IBD; immunogenetics of IBD
- Mikael J. Pittet: In vivo behavior of immune cells in resting and inflammatory conditions
- David H. Sachs: Mechanisms of immune tolerance
- Brian Seed: Genetic analysis of signal transduction
- Arlene Sharpe: Immune regulation
- Lynda Stuart: Identification of the muramyl dipeptide transporter in phagocytes required for NOD2 and NALP3 activation
- Andrew M. Tager: Mechanisms of fibrosis at mucosal surfaces
- George C. Tsokos: Gene transcription in autoimmune disorders
- Ulrich H. von Andrian: Mechanisms of migration of leukocytes around the body and the interactions between leukocytes during an immune response
- Bruce D. Walker: Cellular immune response to human viral pathogens
- H. Shaw Warren: TLR signaling in human diseases
MUCOSAL IMMUNOLOGY
- Atul K. Bhan: Pathogenesis of chronic intestinal inflammation in murine models of IBD
- Bobby J. Cherayil: Molecular mechanisms involved in innate immune response to bacteria
- Nicolas Da Silva: Dendritic cell function in the mucosa of the male reproductive tract
- James G. Fox: Role of helicobacter in IBD: man and animal models; development of persistent inflammation and cancer characterization of luminal flora
- Richard Hodin: Regulation of growth and differentiation within intestinal epithelium and alteration in association with intestinal inflammation
- Ciarán P. Kelly: Bacterial-induced epithelial signaling
- Adam Lacy-Hulbert: Alpha(v) integrins, apoptotic cell clearance and mucosal immune homeostasis
- Atsushi Mizoguchi: Mucosal immune response in murine models of colitis
- Emiko Mizoguchi: Functional modulation of colonic epithelial cells in murine models of colitis
- J. Rodrigo Mora: Lymphocyte acquisition of migratory capacity
- Deanna Nguyen: Innate immune control of inflammatory bowel disease
- Biju Parekkadan: Therapeutic use of peripheral tissue antigen display in inflammatory bowel disease via mesenchymal stem cell transplantation
- Hidde Ploegh: The dynamics of this protracted chess game between our bodies and outside invaders
- Hans-Christian Reinecker: Dendritic cell function in IBD; chemokine receptor and regulation of barrier function of intestinal epithelial cells
- Simon C. Robson: Purinergic signaling pathways in IBD
- Hai Ning Shi: Pathogenesis and immune regulation of intestinal inflammation
- Cox Terhorst: SLAM family in innate and adaptive immunity
- Joel Weinstock: Immunology of inflammatory bowel disease
- Seok-Hyun Yun: In vivo confocal and multiphoton endoscopy in animal models of IBD
GENETICS OF COMPLEX DISEASE
- David Altshuler: Genetics of common human disease
- Mark J. Daly: Genetics of Crohn’s disease and ulcerative colitis
- Ramnik J. Xavier: Systems approaches to innate and adaptive immunity
SYSTEMS BIOLOGY/COMPUTATIONAL BIOLOGY
- Abraham Brass: Forward genetic screening to identify host dependency factors in viral infections
- Cosmas Giallourakis: Integrative genomic analysis of transcriptional regulation of B cell development
- Nir Hacohen: Host-pathogen sensing pathways
- Alan S. Kopin: G protein-coupled receptor (GPCR) mediated physiology
- Towia A. Libermann: Biomarkers in IBD and cancer
- Aylwin Ng: Integrative systems biology of microbial sensing, autophagy, innate immune regulation and programming
- Stanley Y. Shaw: Chemical biology approaches assigning function to human disease mutations
- Ralph Weissleder: In vivo molecular imaging
- Junying Yuan: Cell biology of autophagy and necrosis
CLINICAL AND TRANSLATIONAL MEDICINE
- Andrew T. Chan: Lifestyle risk factors for gastrointestinal cancer
- Chin Hur: Clinical predictors and health outcomes in gastrointestinal diseases
- Gregory Lauwers: Histopathology correlates of IBD
- Alan Moss: Translational and clinical studies in inflammatory bowel disease
