Center for the Study of IBD

CSIBD Investigators and Associate Investigators are listed below. For individual contact information, please follow the website links.

Eric J. Alm, PhD
CSIBD Investigator
MIT/Broad Institute
Interest: Computational/theoretical and experimental approaches to understanding the evolution of microorganisms, emphasizing a 'systems-level' perspective

David Altshuler, MD, PhD
CSIBD Investigator
MIT/Broad Institute
Interest: Genetics of common human disease

Ashwin Ananthakrishnan, MBBS, MPH
CSIBD Investigator
MGH/HMS
Interest: Epidemiology and outcomes of IBD and development of personalized medicine approach

Robert Anthony, PhD
CSIBD Investigator
MGH/HMS
Interest: Interplay of inflammation and glycosylation

M. Amin Arnaout, MD
CSIBD Investigator
MGH/HMS
Interest: Neutrophil-endothelial interactions; role of CD11/18

Joseph Avruch, MD
CSIBD Investigator
MGH/HMS
Interest: Molecular biology of signaling in response to growth factors

Atul K. Bhan, MD
CSIBD Investigator
MGH/HMS
Interest: Pathogenesis of chronic intestinal inflammation in murine models of IBD

Paul Blainey, PhD
CSIBD Investigator
MIT/Broad Institute
Interest: Integration of microfluidic, optical, and molecular tools for application in biology and medicine

Abraham L. Brass, MD, PhD
CSIBD Investigator
MGH/HMS (Current location: University of Massachusetts Medical School)
Interest: Forward genetic screening to identify host dependency factors in viral infections

Shannon Bromley, PhD
CSIBD Associate Investigator
MGH/HMS
Interest: Visualization of CCR4-directed Treg control of IBD

Dennis Brown, PhD
CSIBD Investigator
MGH/HMS
Interest: Structural basis of functional membrane specialization in polarized epithelial cells and regulation of aquaporin family of water channels in fluid and electrolyte homeostasis in IBD

Stephen B. Calderwood, MD
CSIBD Investigator
MGH/HMS
Interest: Mechanisms of toxin-mediated mucosal injury; modeling of bacterial-host interactions

Arup K. Chakraborty, PhD
CSIBD Investigator
MIT
Interest: Computational and theoretical studies, rooted in physics and engineering, of the adaptive immune system

Andrew Chan, MD, MPH
CSIBD Investigator
MGH/HMS
Interest: Lifestyle risk factors for gastrointestinal cancer

Wei Chao, MD, PhD
CSIBD Associate Investigator
MGH/HMS
Interest:Toll-like receptor (TLR) signaling in ischemic myocardial injury, TLRs in cardiac dysfunction during polymicrobial sepsis

Bobby J. Cherayil, MD
CSIBD Investigator
MGH/HMS
Interest: Molecular mechanisms involved in innate immune response to bacteria

Michael Y. Choi, MD
CSIBD Associate Investigator
MGH/HMS
Interest: Regulation of gut development and its relationship to colitis and cancer

Raymond T. Chung, MD
CSIBD Investigator
MGH/HMS
Interest: Immune responses to HCV

Nicolas Da Silva, PhD
CSIBD Investigator
MGH/HMS
Interest: Dendritic cell function in the mucosa of the male reproductive tract

Mark J. Daly, PhD
CSIBD Investigator
MGH/HMS/Broad
Interest:
Genetics of Crohn's disease and ulcerative colitis

Alessio Fasano, MD
CSIBD Investigator
HMS/MGHfC
Interest: Molecular mechanisms of autoimmune disorders 

Kate Fitzgerald, PhD
CSIBD Investigator
University of Massachusetts Medical School
Interest:inflammasomes, innate immunity, intestinal inflammation

James G. Fox, DVM
CSIBD Investigator
MIT
Interest: Role of Helicobacter in IBD: man and animal models; development of persistent inflammation and cancer characterization of luminal flora

Dai Fukumura, MD, PhD
CSIBD Investigator
HMS/MGH
Interest: Role of inflammation and immunity in angiogenesis, tumor growth and treatment response

John J. Garber, III, MD
CSIBD Associate Investigator
MGH/HMS
Interest:Actin cytoskeleton regulation in intercellular junctions within the intestinal epithelium

Dirk Gevers, PhD
CSIBD Associate Investigator
Broad Institute
Interest: Microbiome; microbial genomics and evolution

Cosmas C. Giallourakis, MD
CSIBD Associate Investigator
MGH/HMS
Interest: Integrative genomic analysis of transcriptional regulation of B cell development

Marcia B. Goldberg, MD
CSIBD Investigator
MGH/HMS
Interest: Mechanisms of bacterial (Shigella) invasion of intestinal epithelium: epithelial signaling in response to bacteria

Allan M. Goldstein, MD
CSIBD Investigator
MGH/HMS
Interest: Enteric nervous system development

Daniel Graham, PhD
CSIBD Associate Investigator
MGH/HMS
Interest: Coordination of innate and adaptive immunity, inflammatory pathologies, signal transduction

Nir Hacohen, PhD
CSIBD Investigator
MGH/HMS
Interest: Host-pathogen sensing pathways

Kevin M. Haigis, PhD
CSIBD Investigator
MGH/HMS
Interest: Nras as a modulator of DSS-induced epithelial damage and colitis

Jason B. Harris, MD
CSIBD Investigator
HMS/MGHfC
Interest: Host-pathogen interactions in enteric infections

Richard A. Hodin, MD
CSIBD Investigator
MGH/HMS
Interest: Regulation of growth and differentiation within intestinal epithelium and alteration in association with intestinal inflammation

Deborah T. Hung, MD, PhD
CSIBD Investigator
MGH/HMS
Interest: Genomic and chemical approaches to bacterial pathogenesis

Curtis Huttenhower, PhD
CSIBD Investigator
HSPH/HMS
Interest: Large-scale genomic data mining

Javier Irazoqui, PhD
CSIBD Investigator
MGH
Interest: Host defense; bacterial pathogenesis; pathogen specificity

Ralph Isberg, PhD
CSIBD Investigator
Tufts University
Interest: Mechanisms of pathogenesis by bacteria

Rakesh Jain, PhD
CSIBD Investigator
HMS/MGH
Interest: Role of the tumor microenvironment in colorectal cancer

Kate Jeffrey, PhD
CSIBD Investigator
MGH/HMS
Interest: Cell signaling, global gene expression, epigenetics and small non-coding RNAs

J. Keith Joung, MD, PhD
CSIBD Investigator
HMS/MGH/Broad Institute
Interest: Development and applications of genome editing technologies

Lee M. Kaplan, MD, PhD
CSIBD Investigator
MGH/HMS
Interest: Genetic and genomics of obesity

Hamed Khalili, MD, MPH
CSIBD Associate Investigator
MGH/HMS
Interest: Dietary, reproductive, and lifestyle factors in IBD, and their interplay with common genetic risk loci and gut microbial environment

Douglas S. Kwon, MD, PhD
CSIBD Investigator
HMS
Interest: Role of gut in HIV pathogenesis

Regina LaRocque, MD, MPH
CSIBD Associate Investigator
MGH/HMS
Interest: Host response to V. cholerae infection, genetics of susceptibility to V. cholerae infection

Georg M. Lauer, MD, PhD
CSIBD Investigator
MGH/HMS
Interest: Adaptive immune responses to viral pathogens

Doug Lauffenburger, PhD
CSIBD Investigator
MIT
Interest: Translating systems biology approaches to in vivo studies

Gregory Y. Lauwers, MD
CSIBD Associate Investigator
MGH/HMS
Interest: Histopathology correlates of IBD

Cammie F. Lesser, MD, PhD
CSIBD Investigator
MGH/HMS
Interest: Molecular mechanisms of enteric bacterial pathogenesis

Towia A. Libermann, PhD
CSIBD Investigator
BIDMC/HMS
Interest: Biomarkers in IBD and cancer

Timothy K. Lu, MD, PhD
CSIBD Investigator
MIT/Broad Institute
Interest: Advancing fundamental designs and applications for synthetic biology

Andrew D. Luster, MD, PhD
CSIBD Investigator
MGH/HMS
Interest: Chemokine receptors and mechanisms of chemokine action in lymphocyte recruitment and differentiation in IBD/allergy/asthma

Daniel MacArthur, PhD
CSIBD Investigator
MGH/Broad
Interest:Predicting the functional impact of genetic variants obtained from high-throughput sequencing data

Anna Mandinova, MD, PhD
CSIBD Investigator
MGH/HMS
Interest: Chemical biology approaches and models of epithelial tumorigenesis and regulation of keratinocyte proliferation

Tanya N. Mayadas, PhD
CSIBD Investigator
HMS
Interest: Mechanisms of inflammation

Terry K. Means, PhD
CSIBD Investigator
MGH/HMS
Interest: Molecular and cellular mechanisms of inflammation and host defense

Joan Mecsas, PhD
CSIBD Investigator
Tufts
Interest: Role of bacterial effectors on cells of the GI tract in modulating immune responses

Thorsten R. Mempel, MD, PhD
CSIBD Investigator
MGH/HMS
Interest: Controls of T cell effector function

Emiko Mizoguchi, MD, PhD
CSIBD Investigator
MGH/HMS
Interest: Functional modulation of colonic epithelial cells in murine models of colitis

James Moon, PhD
CSIBD Investigator
MGH/HMS
Interest: CD4+ T cell tolerance

Vamsi Mootha, MD
CSIBD Investigator
HMS/MGH/Broad Institute
Interest: Genomics and systems biology to understand mitochondrial physiology

Alan Moss, MD
CSIBD Associate Investigator
BIDMC/HMS
Interest: Translational and clinical studies in inflammatory bowel disease

Raul Mostoslavsky, MD, PhD
CSIBD Investigator
MGH/HMS
Interest: Chromatin dynamics and regulation of gene transcription, DNA recombination and DNA repair

Alan Mullen, MD, PhD
CSIBD Associate Investigator
MGH/HMS
Interest: TGF-beta signaling and the regulation of the activity of coding and non-coding genes in health and disease

Benjamin Neale, PhD
CSIBD Investigator
MGH/Broad
Interest:Development and application of statistical methodology with a focus on methods specifically for genetic analysis

Aylwin Ng, PhD
CSIBD Associate Investigator
MGH/HMS
Interest: Computational biology

Deanna D. Nguyen, MD
CSIBD Associate Investigator
MGH/HMS
Interest: Role of actin regulation in the pathogenesis of inflammatory bowel disease

Pier Paolo Pandolfi, MD, PhD
CSIBD Investigator
HMS/BIDMC
Interest: Molecular genetics and mechanisms that lead to tumorigenesis

Hongkun Park, PhD
CSIBD Investigator
HMS/Broad
Interest: Optoelectronics and plasmonics using nanostructures, nano-bio interfacing, and neuro-electronic devices

Jin Mo Park, PhD
CSIBD Investigator
MGH/HMS
Interest: Innate immune function of p38 MAP kinase

Norbert Perrimon, PhD
CSIBD Investigator
HMS
Interest: The adult Drosophila gut: a model system for stem cell biopsy and intestinal cancer

Shiv Pillai, MD, PhD
CSIBD Investigator
MGH/HMS
Interest: Regulation of B cell development in IBD; immunogenetics of IBD

Mikael J. Pittet, PhD
CSIBD Investigator
MGH/HMS
Interest: In vivo behavior of immune cells in resting and inflammatory conditions

Hidde Ploegh, PhD
CSIBD Investigator
MIT
Interest: The dynamics of this protracted chess game between our bodies and outside invaders

Alexander Poltorak, PhD
CSIBD Investigator
Tufts
Interest: Genetic analysis to discover new components and signaling pathways of innate immune responses

Frederic I. Preffer, PhD
CSIBD Associate Investigator
MGH/HMS
Interest: Side populations [SP] cells, which are relatively rare cells found in both the circulation and bone marrow

Aviv Regev, PhD
CSIBD Investigator
MIT/Broad
Interest:Biological networks, gene regulation and evolution

Hans-Christian Reinecker, MD
CSIBD Investigator
MGH/HMS
Interest: Mucosal immunity, innate immune defenses, dendritic cell function and intestinal microbiome

John L. Rinn, PhD
CSIBD Investigator
Harvard/Broad Institute
Interest: Misregulation of long non-coding RNAs in disease

Simon C. Robson, MD, PhD
CSIBD Investigator
BIDMC/HMS
Interest: Purinergic signaling pathways in IBD

Evan Rosen, MD, PhD
CSIBD Investigator
BIDMC/HMS/Broad Institute
Interest: Transcriptional pathways in metabolic tissues

Edward T. Ryan, MD
CSIBD Investigator
MGH/HMS
Interest: Enteric bacterial factors inducing epithelial invasions: development of mucosal vaccines

David Sabatini, MD, PhD
CSIBD Investigator
MIT/Whitehead Institute
Interest: Mechanisms that regulate cell growth

Jenny Sauk, MD
CSIBD Associate Investigator
MGH/HMS
Interest: Clinical treatments for ulcerative colitis, Crohn's disease, microscopic colitis, celiac disease, and gastrointestinal cancer

Stuart L. Schreiber, PhD
CSIBD Investigator
Harvard/Broad Institute
Interest: Discovery and use of small molecules to explore cell circuitry and disease biology

Brian Seed, PhD
CSIBD Investigator
MGH/HMS
Interest: Genetic analysis of signal transduction

Alykhan Shamji, PhD
CSIBD Associate Investigator
Broad Institute
Interest: Discovery of small molecules that modulate pathways implicated in disease

Arlene H. Sharpe, MD, PhD
CSIBD Investigator
HMS
Interest: Immune regulation

Stanley Y. Shaw, MD, PhD
CSIBD Associate Investigator
MGH/HMS
Interest: Chemical biology approaches assigning function to human disease mutations

Hai Ning Shi, DVM, PhD
CSIBD Investigator
MGH/HMS
Interest: Pathogenesis and immune regulation of intestinal inflammation

Wayne G. Shreffler, MD, PhD
CSIBD Investigator
MGH/HMS
Interest:  Pathogenic mechanisms of food allergy and asthma

Bruce Spiegelman, PhD
CSIBD Investigator
HMS
Interest: Role of gene transcription in energy homeostasis

Timothy A. Springer, PhD
CSIBD Investigator
HMS
Interest: Integrins in the treatment of Crohn's disease

Vikas P. Sukhatme, MD, PhD
CSIBD Investigator
BIDMC/HMS
Interest: Tumor immunology and metabolism

Andrew M. Tager, MD
CSIBD Investigator
MGH/HMS
Interest: Mechanisms of fibrosis at mucosal surfaces

Cornelis P. Terhorst, PhD
CSIBD Investigator
BIDMC/HMS
Interest: SLAM family in innate and adaptive immunity

George C. Tsokos, MD
CSIBD Investigator
BIDMC/HMS
Interest: Gene transcription in autoimmune disorders

Jatin M. Vyas, MD, PhD
CSIBD Investigator
MGH/HMS
Interest: Dendritic cell pathogen responses in immunity

Bruce D. Walker, MD
CSIBD Investigator
MGH/HMS
Interest: Cellular immune response to human viral pathogens

W. Allan Walker, MD
CSIBD Investigator
MGH/HMS
Interest: Gastrointestinal host defenses, particularly as they pertain to the role of enteric nutrients

Honorine Ward, MBBS
CSIBD Investigator
Tufts University
Interest: Host-parasite interactions of cryptosporidium

H. Shaw Warren, MD
CSIBD Investigator
MGH/HMS
Interest: TLR signaling in human diseases

Joel V. Weinstock, MD
CSIBD Investigator
Tufts University
Interest: Immunology of inflammatory bowel disease

Ralph Weissleder, MD, PhD
CSIBD Investigator
MGH/HMS
Interest: In vivo molecular imaging

Ramnik Xavier, MD, PhD
CSIBD Investigator
MGH/HMS
Interest: Systems approaches to innate and adaptive immunity

Vijay Yajnik, MD, PhD
CSIBD Associate Investigator
MGH/HMS
Interest: Functional analysis of DOCK4

Omer Yilmaz, MD, PhD
CSIBD Associate Investigator
MIT/MGH
Interest: Role of intestinal stem cells in IBD

Junying Yuan, PhD
CSIBD Investigator
HMS
Interest: Cell biology of autophagy and necrosis

Seok-Hyun Yun, PhD
CSIBD Investigator
MGH/HMS
Interest: In vivo confocal and multiphoton endoscopy in animal models of IBD

Feng Zhang, PhD
CSIBD Investigator
MIT/Broad Institute
Interest: Tools to perturb and edit the genome to allow rapid production of new animal models for complex genetic diseases

Lawrence R. Zukerberg, MD
CSIBD Associate Investigator
MGH/HMS
Interest: Role of cables in colitis and cancer