Center for the Study of IBD

CSIBD Investigators listed alphabetically. For individual contact information, follow the website links.

Eric J. Alm, PhD 
MIT/Broad Institute
Interest: Computational/theoretical and experimental approaches to understanding the evolution of microorganisms, emphasizing a 'systems-level' perspective

Frederick W. Alt, PhD
HMS
Interest: Genomic instability and B lymphocyte development

David Altshuler, MD, PhD
MIT/Broad Institute
Interest: Genetics of common human disease

M. Amin Arnaout, MD
MGH/HMS
Interest: Neutrophil-endothelial interactions; role of CD11/18

Dennis A. Ausiello, MD
MGH/HMS
Interest: Epithelial fluid transport and membrane turnover

Frederick M. Ausubel, PhD
MGH/HMS
Interest: Innate immunity and host-pathogen interactions

Joseph Avruch, MD
MGH/HMS
Interest: Molecular biology of signaling in response to growth factors

Atul K. Bhan, MD
MGH/HMS
Interest: Pathogenesis of chronic intestinal inflammation in murine models of IBD

Sarah L. Booth, PhD 
Tufts University
Interest: Impact of vitamin K on vascular health and immune function

Dennis Brown, PhD
MGH/HMS
Interest: Structural basis of functional membrane specialization in polarized epithelial cells and regulation of aquaporin family of water channels in fluid and electrolyte homeostasis in IBD

Stephen B. Calderwood, MD
MGH/HMS
Interest: Mechanisms of toxin-mediated mucosal injury; modeling of bacterial-host interactions

Andrew Chan, MD, MPH
MGH/HMS
Interest: Lifestyle risk factors for gastrointestinal cancer

Bobby J. Cherayil, MD
MGH/HMS
Interest: Molecular mechanisms involved in innate immune response to bacteria

Daniel C. Chung, MD
MGH/HMS
Interest: Tumor suppressor genes in IBD associated cancer: characterization of cell signaling pathway and regulation by VEGF genes; angiogenesis in colon cancer

Raymond T. Chung, MD 
MGH/HMS
Interest: Immune responses to HCV

Mark J. Daly, PhD
MGH/HMS/Broad
Interest:
Genetics of Crohn's disease and ulcerative colitis

Joseph El Khoury, MD
MGH/HMS
Interest: Regulation of macrophage functions by scavenger receptors

James G. Fox, DVM
MIT
Interest: Role of helicobacter in IBD: man and animal models; development of persistent inflammation and cancer characterization of luminal flora

Robert E. Gerszten, MD
MGH/HMS
Interest: Role of chemokines in modulating inflammation

Marcia B. Goldberg, MD 
MGH/HMS
Interest: Mechanisms of bacterial (Shigella) invasion of intestinal epithelium: epithelial signaling in response to bacteria

Allan M. Goldstein, MD
MGH/HMS
Interest: Enteric nervous sytem development

Nir Hacohen, PhD 
MGH/HMS
Interest: Host-pathogen sensing pathways

Richard A. Hodin, MD
MGH/HMS
Interest: Regulation of growth and differentiation within intestinal epithelium and alteration in association with intestinal inflammation

Curtis Huttenhower, PhD
HSPH/HMS
Interest: Large-scale genomic data mining

Javier Irazoqui, PhD
MGH
Interest: Host defense; bacterial pathogenesis; pathogen specificity

Ralph Isberg, PhD
Tufts University
Interest: Mechanisms of pathogenesis by bacteria

Lee M. Kaplan, MD, PhD
MGH/HMS
Interest: Genetic and genomics of obesity

Ciarán P. Kelly, MD

BIDMC/HMS
Interest: Bacterial-induced epithelial signaling

Alan S. Kopin, MD
Tufts University
Interest: G protein-coupled receptor (GPCR) mediated physiology

Georg M. Lauer, MD, PhD
MGH/HMS
Interest: Adaptive immune responses to viral pathogens

Gregory Y. Lauwers, MD
MGH/HMS
Interest: Histopathology correlates of IBD

John Leong, MD, PhD
Tufts University
Interest: Interaction of bacterial pathogens with host cells

Cammie F. Lesser, MD, PhD
MGH/HMS
Interest: Molecular mechanisms of enteric bacterial pathogenesis

Towia A. Libermann, PhD
BIDMC/HMS
Interest: Biomarkers in IBD and cancer

Herbert Y. Lin, MD, PhD
MGH/HMS
Interest: Regulation of TGFβ and other growth factors expression: molecular mechanisms of injury

Andrew D. Luster, MD, PhD
MGH/HMS
Interest: Chemokine receptors and mechanisms of chemokine action in lymphocyte recruitment and differentiation in IBD/allergy/asthma

Daniel MacArthur, PhD
MGH/Broad
Interest: Predicting the functional impact of genetic variants obtained from high-throughput sequencing data

Beth A. McCormick, PhD
U Mass Medical
Interest: Mucosal inflammation, host:pathogen interactions, and cancer biology

Benjamin D. Medoff, MD
MGH/HMS
Interest: Carma proteins and NF-κB activation

Atsushi Mizoguchi, MD, PhD
MGH/HMS
Interest: Mucosal immune response in murine models of colitis

Emiko Mizoguchi, MD, PhD
MGH/HMS
Interest: Functional modulation of colonic epithelial cells in murine models of colitis

Raul Mostoslavsky, MD, PhD
MGH/HMS
Interest: Chromatin dynamics and regulation of gene transcription, DNA recombination and DNA repair

Hongkun Park, PhD
HMS/Broad
Interest: Optoelectronics and plasmonics using nanostructures, nano-bio interfacing, and neuro-electronic devices

Jin Mo Park, PhD
MGH/HMS
Interest: Innate immune function of p38 MAP kinase

Norbert Perrimon, PhD
HMS
Interest: The adult Drosophila gut: a model system for stem cell biopsy and intestinal cancer

Shiv S. Pillai, MD, PhD
MGH/HMS
Interest: Regulation of B cell development in IBD; immunogenetics of IBD

Frederic I. Preffer, PhD
MGH/HMS
Interest: Side populations [SP] cells, which are relatively rare cells found in both the circulation and bone marrow

Laurence Rahme, PhD
MGH/HMS
Interest:
Multi-host pathogenesis and anti-infective agents

Aviv Regev, PhD
MIT/Broad
Interest: Biological networks, gene regulation and evolution

Hans-Christian Reinecker, MD
MGH/HMS
Interest: Mucosal immunity, innate immune defenses, dendritic cell function and intestinal microbiome

David B. Rhoads, PhD
MGH/HMS
Interest: Metabolic disorders of Type 2 diabetes and obesity

Simon C. Robson, MD, PhD
BIDMC/HMS
Interest: Purinergic signaling pathways in IBD

Edward T. Ryan, MD
MGH/HMS
Interest: Enteric bacterial factors inducing epithelial invasions: development of mucosal vaccines

David Sabatini, MD, PhD 
MIT/Whitehead Institute
Interest: Mechanisms that regulate cell growth

David H. Sachs, MD 
MGH/HMS
Interest: Mechanisms of immune tolerance

Brian Seed, PhD
MGH/HMS
Interest: Genetic analysis of signal transduction

Arlene H. Sharpe, MD, PhD

HMS
Interest: Immune regulation

Vikas P. Sukhatme, MD, PhD
BIDMC/HMS
Interest: Tumor immunology and metabolism

Andrew M. Tager, MD
MGH/HMS
Interest: Mechanisms of fibrosis at mucosal surfaces

Steven R. Tannenbaum, PhD
MIT
Interest: The relationship between exposure to environmental and endogenous chemicals and risk of cancer and other diseases

Cornelis P. Terhorst, PhD
BIDMC/HMS
Interest: SLAM family in innate and adaptive immunity

Ronald Gary Tompkins, MD, ScD 
MGH
Interest: General Surgery

George C. Tsokos, MD
BIDMC/HMS
Interest: Gene transcription in autoimmune disorders

Ulrich H. Von Andrian, MD, PhD

HMS
Interest: Mechanisms of migration of leukocytes around the body and the interactions between leukocytes during an immune response

Bruce D. Walker, MD

MGH/HMS
Interest: Cellular immune response to human viral pathogens

W. Allan Walker, MD

MGH/HMS
Interest: Gastrointestinal host defenses, particularly as they pertain to the role of enteric nutrients

Honorine D. Ward, MD
Tufts University
Interest: Host-parasite interactions of cryptosporidium

H. Shaw Warren, MD
MGH/HMS
Interest: TLR signaling in human diseases

Joel V. Weinstock, MD
Tufts University
Interest: Immunology of inflammatory bowel disease

Ralph Weissleder, MD, PhD
MGH/HMS
Interest: In vivo molecular imaging

Gerald N. Wogan, PhD
MIT
Interest: Role of NO and ROS in colitis and cancer

Mei Xiong Wu, MD, PhD

MGH/HMS
Interest: Role of IEX1 and Gαi2 in inflammatory bowel disease

Ramnik Xavier, MD, PhD
MGH/HMS
Interest: Systems approaches to innate and adaptive immunity

Junying Yuan, PhD
HMS
Interest: Cell biology of autophagy and necrosis