CSIBD Investigators listed alphabetically. For individual contact information, follow the website links.
Eric J. Alm, Ph.D.
MIT/Broad Institute
Interest: Computational/theoretical and experimental approaches to understanding the evolution of microorganisms, emphasizing a 'systems-level' perspective
Frederick W. Alt, Ph.D.
HMS
Interest: Genomic instability and B lymphocyte development
David Altshuler, M.D., Ph.D.
MIT/Broad Institute
Interest: Genetics of common human disease
M. Amin Arnaout, M.D.
MGH/HMS
Interest: Neutrophil-endothelial interactions; role of CD11/18
Dennis A. Ausiello, M.D.
MGH/HMS
Interest: Epithelial fluid transport and membrane turnover
Frederick M. Ausubel, Ph.D.
MGH/HMS
Interest: Innate immunity and host-pathogen interactions
Joseph Avruch, M.D.
MGH/HMS
Interest: Molecular biology of signaling in response to growth factors
Atul K. Bhan, M.D.
MGH/HMS
Interest: Pathogenesis of chronic intestinal inflammation in murine models of IBD
Sarah L. Booth, Ph.D.
Tufts University
Interest: Impact of vitamin K on vascular health and immune function
Dennis Brown, Ph.D.
MGH/HMS
Interest: Structural basis of functional membrane specialization in polarized epithelial cells and regulation of aquaporin family of water channels in fluid and electrolyte homeostasis in IBD
Stephen B. Calderwood, M.D.
MGH/HMS
Interest: Mechanisms of toxin-mediated mucosal injury; modeling of bacterial-host interactions
Lewis C. Cantley, Ph.D.
BIDMC/HMS
Interest: Regulation NF-κB and CARD15-activated pathways and their alteration in Crohn’s disease; PI3Ks and cancer
Andrew Chan, M.D., M.P.H.
MGH/HMS
Interest: Lifestyle risk factors for gastrointestinal cancer
Bobby J. Cherayil, M.D.
MGH/HMS
Interest: Molecular mechanisms involved in innate immune response to bacteria
Daniel C. Chung, M.D.
MGH/HMS
Interest: Tumor suppressor genes in IBD associated cancer: characterization of cell signaling pathway and regulation by VEGF genes; angiogenesis in colon cancer
Raymond T. Chung, M.D.
MGH/HMS
Interest: Immune responses to HCV
Mark J. Daly, Ph.D.
MGH/HMS
Interest: Genetics of Crohn's disease and ulcerative colitis
Joseph El Khoury, M.D.
MGH/HMS
Interest: Regulation of macrophage functions by scavenger receptors
James G. Fox, D.V.M.
MIT
Interest: Role of helicobacter in IBD: man and animal models; development of persistent inflammation and cancer characterization of luminal flora
Robert E. Gerszten, M.D.
MGH/HMS
Interest: Role of chemokines in modulating inflammation
Marcia B. Goldberg, M.D.
MGH/HMS
Interest: Mechanisms of bacterial (Shigella) invasion of intestinal epithelium: epithelial signaling in response to bacteria
Nir Hacohen, Ph.D.
MGH/HMS
Interest: Host-pathogen sensing pathways
Richard A. Hodin, M.D.
MGH/HMS
Interest: Regulation of growth and differentiation within intestinal epithelium and alteration in association with intestinal inflammation
Curtis Huttenhower, Ph.D.
HSPH/HMS
Interest: Large-scale genomic data mining
Javier Irazoqui, Ph.D.
MGH
Interest: Host defense; bacterial pathogenesis; pathogen specificity
Ralph Isberg, Ph.D.
Tufts University
Interest: Mechanisms of pathogenesis by bacteria
Lee M. Kaplan, M.D., Ph.D.
MGH/HMS
Interest: Genetic and genomics of obesity
Ciarán P. Kelly, M.D.
BIDMC/HMS
Interest: Bacterial-induced epithelial signaling
Alan S. Kopin, M.D.
Tufts University
Interest: G protein-coupled receptor (GPCR) mediated physiology
J. Thomas Lamont, M.D.
BIDMC/HMS
Interest: Structure and function of Clostridium difficile toxins
Georg M. Lauer, M.D., Ph.D.
MGH/HMS
Interest: Adaptive immune responses to viral pathogens
Gregory Y. Lauwers, M.D.
MGH/HMS
Interest: Histopathology correlates of IBD
Cammie F. Lesser, M.D., Ph.D.
MGH/HMS
Interest: Molecular mechanisms of enteric bacterial pathogenesis
Towia A. Libermann, Ph.D.
BIDMC/HMS
Interest: Biomarkers in IBD and cancer
Herbert Y. Lin, M.D., Ph.D.
MGH/HMS
Interest: Regulation of TGFβ and other growth factors expression: molecular mechanisms of injury
Andrew D. Luster, M.D., Ph.D.
MGH/HMS
Interest: Chemokine receptors and mechanisms of chemokine action in lymphocyte recruitment and differentiation in IBD/allergy/asthma
Benjamin D. Medoff, M.D.
MGH/HMS
Interest: Carma proteins and NF-κB activation
Atsushi Mizoguchi, M.D., Ph.D.
MGH/HMS
Interest: Mucosal immune response in murine models of colitis
Emiko Mizoguchi, M.D., Ph.D.
MGH/HMS
Interest: Functional modulation of colonic epithelial cells in murine models of colitis
Jin Mo Park, Ph.D.
MGH/HMS
Interest: Innate immune function of p38 MAP kinase
Norbert Perrimon, Ph.D.
HMS
Interest: The adult Drosophila gut: a model system for stem cell biopsy and intestinal cancer
Shiv S. Pillai, M.D., Ph.D.
MGH/HMS
Interest: Regulation of B cell development in IBD; immunogenetics of IBD
Frederic I. Preffer, Ph.D.
MGH/HMS
Interest: Side populations [SP] cells, which are relatively rare cells found in both the circulation and bone marrow
Laurence Rahme, Ph.D.
MGH/HMS
Interest: Multi-host pathogenesis and anti-infective agents
Hans-Christian Reinecker, M.D.
MGH/HMS
Interest: Mucosal immunity, innate immune defenses, dendritic cell function and intestinal microbiome
David B. Rhoads, Ph.D.
MGH/HMS
Interest: Metabolic disorders of Type 2 diabetes and obesity
Simon C. Robson, M.D., Ph.D.
BIDMC/HMS
Interest: Purinergic signaling pathways in IBD
Edward T. Ryan, M.D.
MGH/HMS
Interest: Enteric bacterial factors inducing epithelial invasions: development of mucosal vaccines
David Sabatini, M.D., Ph.D.
MIT/Whitehead Institute
Interest: Mechanisms that regulate cell growth
David H. Sachs, M.D.
MGH/HMS
Interest: Mechanisms of immune tolerance
Brian Seed, Ph.D.
MGH/HMS
Interest: Genetic analysis of signal transduction
Arlene H. Sharpe, M.D., Ph.D.
HMS
Interest: Immune regulation
Lynda M. Stuart, Ph.D.
MGH/HMS
Interest: Identification of the muramyl dipeptide transporter in phagocytes required for NOD2 and NALP3 activation
Vikas P. Sukhatme, M.D., Ph.D.
BIDMC/HMS
Interest: Tumor immunology and metabolism
Andrew M. Tager, M.D.
MGH/HMS
Interest: Mechanisms of fibrosis at mucosal surfaces
Steven R. Tannenbaum, Ph.D.
MIT
Interest: The relationship between exposure to environmental and endogenous chemicals and risk of cancer and other diseases
Cornelis P. Terhorst, Ph.D.
BIDMC/HMS
Interest: SLAM family in innate and adaptive immunity
Ronald Gary Tompkins, M.D., Sc.D.
MGH
Clinical Interest: General Surgery
George C. Tsokos, M.D.
BIDMC/HMS
Interest: Gene transcription in autoimmune disorders
Ulrich H. Von Andrian, M.D., Ph.D.
HMS
Interest: Mechanisms of migration of leukocytes around the body and the interactions between leukocytes during an immune response
Bruce D. Walker, M.D.
MGH/HMS
Interest: Cellular immune response to human viral pathogens
W. Allan Walker, M.D.
MGH/HMS
Interest: Gastrointestinal host defenses, particularly as they pertain to the role of enteric nutrients
Honorine D. Ward, M.D.
Tufts University
Interest: Host-parasite interactions of cryptosporidium
H. Shaw Warren, M.D.
MGH/HMS
Interest: TLR signaling in human diseases
Joel V. Weinstock, M.D.
Tufts University
Interest: Immunology of inflammatory bowel disease
Ralph Weissleder, M.D., Ph.D.
MGH/HMS
Interest: In vivo molecular imaging
Gerald N. Wogan, Ph.D.
MIT
Interest: Role of NO and ROS in colitis and cancer
Mei Xiong Wu, M.D., Ph.D.
MGH/HMS
Interest: Role of IEX1 and Gαi2 in inflammatory bowel disease
Ramnik Xavier, M.D., Ph.D.
MGH/HMS
Interest: Systems approaches to innate and adaptive immunity
Junying Yuan, Ph.D.
HMS
Interest: Cell biology of autophagy and necrosis
