Our Research

Research at the Center for Transplantation Sciences

The Center for Transplantation Sciences (CTS) at Massachusetts General Hospital conducts critical research to increase the success rates of transplantation and meet the growing demand for organ and bone marrow transplantation.

Research Labs

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  • Alessandrini Laboratory

    Alessandro Alessandrini, PhD

    The Alessandrini Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital studies regulatory T cells and plasmacytoid dendritic cells, and the roles they play in the induction of transplantation tolerance.

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  • Benichou Laboratory

    Gilles Benichou, PhD, DSc

    The Benichou Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital studies the immune mechanisms underlying the allorecognition and alloresponse by T and B cells in transplant rejection and tolerance.

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  • Cosimi/Kawai Laboratory

    A. Benedict Cosimi, MD, and Tatsuo Kawai, MD, PhD

    The Cosimi/Kawai Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital focuses on allograft tolerance induction in nonhuman primates and humans, with the goal of developing safe and reliable tolerance-inducing regimens for clinical transplantation.

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  • Hematopoietic Cell Transplantation Laboratory

    Christene A. Huang, PhD

    The Hematopoietic Cell Transplantation Laboratory in the Center for Transplantation Sciences (CTS) studies the immunology of hematopoietic cell transplantation with the goal of eliminating immunological barriers in patients with cancers and other diseases that affect the blood, bone marrow and lymph nodes.

  • Hoggatt Laboratory

    Hoggat Laboratory

    The Hoggatt Laboratory focuses on stem cell biology and the development of novel therapies for cancer and tissue regeneration.

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  • Markmann Laboratory

    James F. Markmann, Md, PhD

    The Markmann Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital examines the hypothesis that a small subset of B cells plays a beneficial or regulatory role in transplant tolerance within the elderly population.

  • Molecular Biology Laboratory

    Christian LeGuern, PhD

    The Molecular Biology Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital focuses on deciphering the role of major histocompatibility class II molecules in the modulation of T cell responses to self and foreign antigens.

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  • Transplantation Biology Research Center (TBRC) Laboratories

    David H. Sachs, MD

    The Transplantation Biology Research Center (TBRC) Laboratories in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital comprises two laboratories investigating tolerance induction in transplantation.

  • Turka Laboratory

    Laurence A. Turka, MD

    The Turka Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital investigates the cellular and molecular aspects of T cell tolerance, with a particular interest in mechanisms of transplant tolerance.

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  • Vagefi Laboratory

    Parsia A. Vagefi, MD

    The Vagefi Laboratory in the Massachusetts General Hospital Center for Transplantation Sciences (CTS) focuses on developing tolerance-inducing strategies utilizing a preclinical model of pig-to-baboon xenotransplantation.

  • Vascularized Composite Allotransplantation Laboratory

    Cetrulo Lab

    The Vascularized Composite Allotransplantation Laboratory in the Massachusetts General Hospital Center for Transplantation Sciences (CTS)investigates the immunobiology of vascularized composite allografts with a primary focus on developing tolerance induction strategies in preclinical models.

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  • Wang Laboratory

    Zhirui Wang, DVM, PhD

    The Wang Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital uses a unique diphtheria toxin-resistant yeast Pichia Pastoris expression system as a platform to develop novel diphtheria toxin-based recombinant immunotoxins/fusion toxins for specific depletion of targeted cell populations in vivo.

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  • Yeh Laboratory

    Heidi Yeh, MD

    The Yeh Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital researches ways to improve access to transplantation and reduce wait list times.

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